Orthopneumovirus (taxid:1868215)

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for 11 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

ENZYMES

RNA-dependent RNA polymerase [L]
Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]

REPLICATION

CYTOPLASMIC

Virus attaches to host cell surface receptors through HN glycoprotein.
Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

DB LINKS

TAXONOMY Group V: Negative sense ssRNA viruses

Realm:	Riboviria
Kingdom:	Orthornavirae
Phylum:	Negarnaviricota
Subphylum:	Haploviricotina
Class:	Monjiviricetes
Order:	Mononegavirales
Family:	Pneumoviridae
Genus:	Orthopneumovirus

VIRUS

Human orthopneumovirus
Bovine orthopneumovirus
Murine orthopneumovirus

REFERENCE STRAIN Human respiratory syncytial virus
Sequence | Genome assembly | Proteome

Host

NATURAL HOST Human, cattle, rodents

CELL TROPISM

INTERACTIONS Cell receptors: HRSV: Heparan sulfate

Host-virus interaction

Ecology and disease

GEOGRAPHY Worldwide

ASSOCIATED DISEASES Respiratory tract disease

TRANSMISSION Respiratory

VACCINE RSV vaccine, approved 2023

ANTIVIRAL DRUGS Palivizumab

Host-virus interaction

Inhibition of host Interferon induction

The NS2 protein plays a role in inhibition of RIG-I antiviral signaling

The NS1 protein plays a role in inhibition of MAVS antiviral signaling

Activation of host NF-kappa-B

The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

86 entries grouped by strain

reorder by protein

11 entries

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

L_BRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

NCAP_BRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)

FUS_BRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

GLYC_BRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

SH_BRSVA Small hydrophobic protein (Small protein 1A)

M21_BRSVA Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)

MATRX_BRSVA Matrix protein (M protein)

PHOSP_BRSVA Phosphoprotein (Protein P)

NS1_BRSVA Non-structural protein 1 (Non-structural protein 1C)

NS2_BRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)

M22_BRSVA Protein M2-2

11 entries

Human respiratory syncytial virus B (strain B1) reference strain

FUS_HRSVB Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening ...

L_HRSVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

SH_HRSVB Small hydrophobic protein (Small protein 1A)

GLYC_HRSVB Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

NS2_HRSVB Non-structural protein 2 (NS2) (Non-structural protein 1B)

MATRX_HRSVB Matrix protein (M protein)

M21_HRSVB Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)

NCAP_HRSVB Nucleoprotein (Protein N) (Nucleocapsid protein)

PHOSP_HRSVB Phosphoprotein (Protein P)

NS1_HRSVB Non-structural protein 1 (Non-structural protein 1C)

M22_HRSVB Protein M2-2

8 entries

Murine pneumonia virus (strain 15) (MPV) reference strain

L_MPV15 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

FUS_MPV15 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

NCAP_MPV15 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

M21_MPV15 Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)

MATRX_MPV15 Matrix protein (M protein)

NS1_MPV15 Non-structural protein 1 (Non-structural protein 1C)

NS2_MPV15 Non-structural protein 2 (NS2) (Non-structural protein 1B)

PHOSP_MPV15 Phosphoprotein (Protein P)

11 entries

Human respiratory syncytial virus

FUS_HRSV Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

8T7A

GLYC_HRSV Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1KWD; 1KWE

L_HRSV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

PHOSP_HRSV Phosphoprotein (Protein P)

M21_HRSV Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1) (Vp24)

5NKX

SH_HRSV Small hydrophobic protein (Small protein 1A)

MATRX_HRSV Matrix protein (M protein)

NCAP_HRSV Nucleoprotein (Protein N) (Nucleocapsid protein)

4V5V

NS2_HRSV Non-structural protein 2 (NS2) (Non-structural protein 1B)

7LDK

NS1_HRSV Non-structural protein 1 (Non-structural protein 1C)

M22_HRSV Protein M2-2

11 entries

Human respiratory syncytial virus A (strain A2)

NCAP_HRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)

2WJ8; 2YHM; 4BKK; 4UC6; 4UC7; 4UC8; 4UC9; 4UCA; 4UCB; 4UCC; 4UCD; 4UCE; 6YJL; 8OOU; 8OP1; 8OP2

FUS_HRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

2MDP; 3IXT; 3KPE; 3O41; 3O45; 3RKI; 3RRR; 3RRT; 4CCF; 4JHW; 4MMQ; 4MMR; 4MMS; 4MMT; 4MMU; 4MMV; 4ZYP; 5C69; 5C6B; 5EA3; 5EA4; 5EA5; 5EA6; 5EA7; 5EA8; 5J3D; 5K6B; 5K6C; 5K6F; 5K6G; 5K6H; 5K6I; 5KWW; 5TOJ; 5TOK; 5TPN; 5U68; 5UDC; 5W23; 6APB; 6APD; 6CXC; 6DC3; 6DC5; 6EAD; 6EAE; 6EAF; 6EAG; 6EAH; 6EAI; 6EAJ; 6EAK; 6EAL; 6EAM; 6EAN; 6NTX; 6OE4; 6OE5; 6OJ7; 6OUS; 6VKC; 6VKD; 6VKE; 6W52; 7LUE; 7LVW; 7MMN; 7MPG; 7TN1; 8DG9; 8KG5; 8PHI; 8ULJ; 8ULK; 8WSQ; 8WZ3; 8WZ4; 9B2X; 9HVW

PHOSP_HRSVA Phosphoprotein (Protein P)

4UCB; 6G0Y; 6PZK; 6UEN; 6YP5; 8FPI; 8FU3; 8SNX; 8SNY; 9C7Y

GLYC_HRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

5WN9; 5WNA; 5WNB; 6UVO; 7T8W; 9CQA; 9CQB; 9CQD

M21_HRSVA Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1) (Vp24)

2L9J; 4C3B; 4C3D; 4C3E; 5NOH; 6G0Y; 6PZQ

SH_HRSVA Small hydrophobic protein (Small protein 1A)

2NB7; 2NB8

MATRX_HRSVA Matrix protein (M protein)

2VQP; 2YKD; 4D4T; 4V23

NS1_HRSVA Non-structural protein 1 (NS1) (Non-structural protein 1C)

L_HRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

6PZK; 6UEN; 8FPI; 8FU3; 8SNX; 8SNY; 9C7Y

NS2_HRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)

M22_HRSVA Protein M2-2

7 entries

Human respiratory syncytial virus B (strain 18537)

FUS_HRSV1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

6Q0S; 8WZ5; 8WZE

GLYC_HRSV1 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

SH_HRSV1 Small hydrophobic protein (Small protein 1A)

NCAP_HRSV1 Nucleoprotein (Protein N) (Nucleocapsid protein)

PHOSP_HRSV1 Phosphoprotein (Protein P)

NS1_HRSV1 Non-structural protein 1 (Non-structural protein 1C)

NS2_HRSV1 Non-structural protein 2 (NS2) (Non-structural protein 1B)

3 entries

Bovine respiratory syncytial virus (strain Rb94) (BRS)

FUS_BRSVR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

GLYC_BRSVR Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

NCAP_BRSVR Nucleoprotein (Protein N) (Nucleocapsid protein)

3 entries

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

SH_HRSS2 Small hydrophobic protein (Small protein 1A)

MATRX_HRSS2 Matrix protein (M protein)

NS1_HRSS2 Non-structural protein 1 (NS1) (Non-structural protein 1C)

2 entries

Bovine respiratory syncytial virus (strain 391-2) (BRS)

2 entries

Bovine respiratory syncytial virus (strain Copenhagen) (BRS)

FUS_BRSVC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

5TDL

GLYC_BRSVC Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1BRV

2 entries

Human respiratory syncytial virus B (strain 8/60)

1 entry

Bovine respiratory syncytial virus (strain 127) (BRS)

1 entry

Bovine respiratory syncytial virus (strain 220-60) (BRS)

1 entry

Bovine respiratory syncytial virus (strain 220-69) (BRS)

1 entry

Bovine respiratory syncytial virus (strain 375) (BRS)

1 entry

Bovine respiratory syncytial virus (strain 4642) (BRS)

1 entry

Bovine respiratory syncytial virus (strain Lelystad) (BRS)

1 entry

Bovine respiratory syncytial virus (strain Snook) (BRS)

1 entry

Bovine respiratory syncytial virus (strain Wbh) (BRS)

1 entry

Human respiratory syncytial virus A (strain RSS-2)

1 entry

Human respiratory syncytial virus A (strain rsb1734)

1 entry

Human respiratory syncytial virus A (strain rsb5857)

1 entry

Human respiratory syncytial virus A (strain rsb6190)

1 entry

Human respiratory syncytial virus A (strain rsb6256)

1 entry

Human respiratory syncytial virus A (strain rsb642)

1 entry

Human respiratory syncytial virus A (strain rsb6614)

These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna

(ModelArchive).

Human respiratory syncytial virus taxid:11250

Protein	ModelArchive
Fusion glycoprotein F0	ma-jd-viral-42968
Matrix protein (M protein)	ma-jd-viral-03354
Non-structural protein 1 (Non-structural protein 1C)	ma-jd-viral-40536
Non-structural protein 2 (Non-structural protein 1B)	ma-jd-viral-50993
Nucleoprotein	ma-jd-viral-52617
Phosphoprotein	ma-jd-viral-35127
Protein M2-1	ma-jd-viral-32282
Small hydrophobic protein (Small protein 1A)	ma-jd-viral-51897
Transcription-replication factor M2-2	ma-jd-viral-32316

Human respiratory syncytial virus B (strain B1) taxid:79692

Protein	ModelArchive
Fusion glycoprotein F0 (Protein F)	ma-jd-viral-42968
Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein)...	ma-jd-viral-54372
Matrix protein (M protein)	ma-jd-viral-03354
Non-structural protein 1 (Non-structural protein 1C)	ma-jd-viral-40536
Non-structural protein 2 (NS2) (Non-structural protein 1B)	ma-jd-viral-50993
Nucleoprotein (Protein N) (Nucleocapsid protein)	ma-jd-viral-52617
Phosphoprotein (Protein P)	ma-jd-viral-35127
Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor...	ma-jd-viral-32282
Protein M2-2	ma-jd-viral-32316
Small hydrophobic protein (Small protein 1A)	ma-jd-viral-51897

Pneumonia virus of mice J3666 taxid:270473

Protein	ModelArchive
Attachment protein	ma-jd-viral-33782
Fusion glycoprotein F0	ma-jd-viral-42981
M2-2	ma-jd-viral-61346
Matrix protein (M protein)	ma-jd-viral-03353
NS1 protein (Non-structural protein 1)	ma-jd-viral-58037
NS2 protein (Non-structural protein 2)	ma-jd-viral-30918
Nucleoprotein	ma-jd-viral-52618
Phosphoprotein	ma-jd-viral-35128
Protein M2-1	ma-jd-viral-32283
Small hydrophobic protein	ma-jd-viral-52217
p2	ma-jd-viral-39714