Due to maintenance work, this service will not be available Thursday August 21st between 7am and 8am CEST.

Isavirus

Molecular biology

VIRION

Enveloped. Usually rounded but can be filamentous. The virions are 90-130 nm in diameter.

GENOME

segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 8 segments coding for at least 8 proteins. Segments size range from 0.8 to 2.2 kb. Genome total size is about 13.5 Kb.

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. Segment 7 mRNA can be alternatively spliced, giving rise to mRNA coding for P6 and P7 proteins.

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though HA protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Matching UniProtKB/Swiss-Prot entries

10 entries grouped by strain (browse by keywords)

10 entries

Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

Select_all Deselect_all  
FUS_ISAV8Fusion glycoprotein F0
HEMA_ISAV8Hemagglutinin-esterase (HE protein) (EC 3.1.1.53)
NCAP_ISAV8Nucleoprotein (Nucleocapsid protein) (Protein N)
P4_ISAV8Protein P4
P5_ISAV8Protein P5
P6_ISAV8Protein P6
P7_ISAV8Protein P7
PA_ISAV8Polymerase acidic protein (RNA-directed RNA polymerase subunit P2)
PB2_ISAV8Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_ISAV8RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic ...