Caveolin-mediated endocytosis of virus by host

fusion lysis permeabilisation


Virus internalization by the host cell via caveolae, which are specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane. Caveolins form the structural backbone of caveolae (CAV1/caveolin-1 and CAV2/caveolin-2 ; CAV3/caveolin-3 in muscle cells). Internalization via caveolae is not a constitutive process but only occurs upon cell stimulation. Internalized viruses bound to their host cell receptor are delivered to the early endosome. It has been first thought that bound viruses were first taken to pH-neutral organelles in the cytoplasm called caveosomes and finally delivered to the ER, but this has been refuted in . Caveolae represent a low capacity but highly regulated pathway .

Matching UniProtKB/Swiss-Prot entries

57 entries grouped by strain (browse by keywords)

All proteins are shown (view only 50 complete proteome entries)

1 entry

Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain


HBSAG_HBVCJLarge envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Simian virus 40 (SV40) reference strain


VP1_SV40Major capsid protein VP1 (Major structural protein VP1)

1 entry

BK polyomavirus (BKPyV)


VP1_POVBKMajor capsid protein VP1 (Major structural protein VP1)

1 entry

BK polyomavirus (strain AS) (BKPyV)


VP1_POVBAMajor capsid protein VP1 (Major structural protein VP1)

1 entry

Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)


POLG_EC01FGenome polyprotein

1 entry

Hepatitis B virus genotype A1 subtype adw (isolate Philippines/pFDW294/1988) (HBV-A)


HBSAG_HBVA5Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)


HBSAG_HBVA6Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype A1 subtype adw2 (isolate Southern-Africa/Cai) (HBV-A)


HBSAG_HBVA1Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)


HBSAG_HBVA7Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)


HBSAG_HBVA2Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)


HBSAG_HBVA4Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)


HBSAG_HBVA3Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)


HBSAG_HBVA9Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)


HBSAG_HBVA8Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)


HBSAG_HBVB4Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)


HBSAG_HBVB8Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)


HBSAG_HBVB7Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)


HBSAG_HBVB1Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)


HBSAG_HBVB2Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)


HBSAG_HBVB5Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)


HBSAG_HBVB3Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)


HBSAG_HBVB6Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)


HBSAG_HBVC0Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)


HBSAG_HBVC5Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (isolate China/NC-1/1988) (HBV-C)


HBSAG_HBVC6Small envelope protein (S glycoprotein) (S-HBsAg) (SHB) (Small S protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)


HBSAG_HBVC8Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)


HBSAG_HBVC1Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (isolate Korea/Kim/1989) (HBV-C)


HBSAG_HBVC4Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)


HBSAG_HBVC3Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)


HBSAG_HBVC2Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)


HBSAG_HBVC9Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)


HBSAG_HBVC7Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)


HBSAG_HBVD2Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)


HBSAG_HBVD7Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D)


HBSAG_HBVD1Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)


HBSAG_HBVD5Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D)


HBSAG_HBVD3Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)


HBSAG_HBVD6Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)


HBSAG_HBVD4Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)


HBSAG_HBVE2Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)


HBSAG_HBVE4Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)


HBSAG_HBVE1Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype F1 (isolate Argentina/sa11/2000) (HBV-F)


HBSAG_HBVF3Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)


HBSAG_HBVF4Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)


HBSAG_HBVF1Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)


HBSAG_HBVF6Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)


HBSAG_HBVG3Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)


HBSAG_HBVH1Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)


HBSAG_HBVH2Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)


HBSAG_HBVH3Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) ...

1 entry

Human papillomavirus type 31


VL1_HPV31Major capsid protein L1

1 entry

Murine polyomavirus (strain 3) (MPyV)


VP1_POVM3Major capsid protein VP1 (Major structural protein VP1)

1 entry

Murine polyomavirus (strain A2) (MPyV)


VP1_POVMAMajor capsid protein VP1 (Major structural protein VP1)

1 entry

Murine polyomavirus (strain Crawford small-plaque) (MPyV)


VP1_POVMCMajor capsid protein VP1 (Major structural protein VP1)

1 entry

Murine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)


VP1_POVMKMajor capsid protein VP1 (Major structural protein VP1)

1 entry

Murine polyomavirus (strain P16 small-plaque) (MPyV)


VP1_POVMPCapsid protein VP1

1 entry

Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)


POLG_POL3LGenome polyprotein