Adenoviridae

Molecular biology

VIRION

Non enveloped, icosahedral capsid with a T=25 symmetry. Capsid’s diameter is about 90-120nm.

GENOME

Non segmented, linear double-stranded DNA of 35-36kb. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly). All genes are transcribed by host RNA pol II except VA gene which is transcribed by RNA pol III. Genes transcribed by RNA pol II give rise to multiple mRNA that are differentiated by alternative splicing and use of different poly(A) sites.

REPLICATION

NUCLEUS

  1. Virus attaches to host receptors though the fiber glycoproteins and is endocytosed into vesicles in the host cell.
  2. Disruption of the endosome releases the viral capsid in the cytosol. released into the nucleus.
  3. Transcription of early genes (E genes), replication of the DNA genome in the nucleus.
  4. Transcription of late genes (L genes), mostly encoding for structural proteins.
  5. Assembly of new virions in the nucleus.
  6. Virions are released by lysis of the cell.
DB LINKS

Nucleotide DB: NCBI
Protein DB: UniProtKB

TAXONOMY Group I: dsDNA Viruses
Family: Adenoviridae
Genus: Atadenovirus
Aviadenovirus
Ichtadenovirus
Mastadenovirus
Siadenovirus
ETYMOLOGY The virus was first isolated from Adenoid tissue.
SPECIES
Type: Human adenovirus C (HAdV-C)
Fowl adenovirus A (FAdV-A)
Ovine adenovirus D (OadV-D)
Frog adenovirus (FrAdV)
Main: Human adenovirus A (HAdV-A)
Human adenovirus B (HAdV-B)
Human adenovirus C (HAdV-C)
Human adenovirus D (HAdV-D)
Human adenovirus E (HAdV-E)
Human adenovirus F (HAdV-F)
Bovine adenovirus A (BAdV-A)
Bovine adenovirus B (BAdV-B)
Bovine adenovirus C (BAdV-C)
Porcine adenovirus A (PAdV-A)
Porcine adenovirus B (PAdV-B)
Porcine adenovirus C (PAdV-C)
REFERENCE STRAINS Human adenovirus C serotype 1
Sequence | Genome | Proteome
Fowl adenovirus A
Sequence | Genome | Proteome
Ovine adenovirus D
Sequence | Genome | Proteome
Frog adenovirus
Sequence | Genome | Proteome
HOST Vertebrates.
CELL TROPISM -
CELL RECEPTOR (S) HAdV A, C, D, E and F: CXADR
HAdV B: CD80 CD86
HAdV B2 and HAdV-3: CD46

Epidemiology

GEOGRAPHY worldwide
ASSOCIATED DISEASES Human adenoviruses: mainly respiratory diseases, croup, and bronchitis, pneumonias. Also keratoconjunctivitis, cystitis and gastroenteritis.
Fowl adenovirus C: hydropericardium syndrome (HPS) also known as Angara disease.
TRANSMISSION Respiratory droplets, fecal-oral route
VACCINE Human adenovirus E serotype 4 and Human adenovirus B serotype 7 for the military.
Vaccine for hydropericardium syndrome (HPS), made from inactivated fowl adenovirus C serotype 4.
ANTIVIRAL DRUGS None

Matching UniProtKB/Swiss-Prot entries

82 entries grouped by strain

Only complete proteome entries are shown ( view all 367 entries)

38 entries

Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

Select_all Deselect_all  
ADEN_ADEG1Adenain (EC 3.4.22.39) (Endoprotease) (Late L3 23 kDa protein)
DNB2_ADEG1Early E2A DNA-binding protein
DPOL_ADEG1DNA polymerase (EC 2.7.7.7)
DUT_ADEG1Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
FIB1_ADEG1Fiber protein 1

pdb 2IUM  2IUN 

FIB2_ADEG1Fiber protein 2

pdb 2VTW 

GAM1_ADEG1Protein GAM-1 (Gallus-anti morte protein) (Gam1)
HEX3_ADEG1Peripentonal hexon-associated protein (Protein IIIa)
HEX8_ADEG1Hexon-associated protein (Protein VIII) (pVIII)
HEX_ADEG1Hexon protein

pdb 2INY 

L100_ADEG1Late 100 kDa protein
L2MU_ADEG1Late L2 mu core protein (Protein X) (pX) (pMu)
L52_ADEG1Late L1 52 kDa protein
PEN3_ADEG1Penton protein (Penton base protein) (Virion component III) (pIII)
PIV6_ADEG1Minor capsid protein 6 (Minor capsid protein VI)
PIVA2_ADEG1Maturation protein (Protein IVA2)
TERM_ADEG1DNA terminal protein (Bellett protein) (pTP protein)
VCO7_ADEG1Major core protein (Protein VII) (pVII)
YO10_ADEG1Putative Ig-like domain-containing protein ORF10
YO11_ADEG1Uncharacterized protein ORF11
YO12_ADEG1Uncharacterized protein ORF12
YO13_ADEG1Uncharacterized protein ORF13
YO14_ADEG1Uncharacterized protein ORF14
YO15_ADEG1Uncharacterized protein ORF15
YO16_ADEG1Uncharacterized protein ORF16
YO17_ADEG1Uncharacterized protein ORF17
YO18_ADEG1Uncharacterized protein ORF18
YO19_ADEG1Uncharacterized protein ORF19
YO20_ADEG1Uncharacterized protein ORF20
YO21_ADEG1Uncharacterized protein ORF21
YO22_ADEG1Uncharacterized protein ORF22
YO2_ADEG1Uncharacterized protein ORF2
YO3_ADEG1Uncharacterized protein ORF3
YO4_ADEG1Uncharacterized protein ORF4
YO5_ADEG1Uncharacterized protein ORF5
YO6_ADEG1Uncharacterized protein ORF6
YO7_ADEG1Uncharacterized protein ORF7
YO9_ADEG1Uncharacterized protein ORF9

1 entry

Frog adenovirus 1 (strain ATCC VR-896) (FrAdV-1) reference strain


ADEN_ADEF1Adenain (EC 3.4.22.39) (Endoprotease) (Late L3 23 kDa protein)

1 entry

Ovine adenovirus D serotype 7 (isolate OAV287) (OAdV-7) (Ovine adenovirus 7) reference strain


ADEN_ADEO7Adenain (EC 3.4.22.39) (Endoprotease) (Late L3 23 kDa protein)

42 entries

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)

Select_all Deselect_all  
ADEN_ADE02Adenain (EC 3.4.22.39) (Endoprotease) (Late L3 23 kDa protein)

pdb 1AVP  1NLN 

DNB2_ADE02Early E2A DNA-binding protein
DNBI_ADE02Probable DNA-binding protein (Agnoprotein)
DPOL_ADE02DNA polymerase (EC 2.7.7.7)
E1A_ADE02Early E1A 32 kDa protein
E1BL_ADE02E1B protein, large T-antigen (E1B 55 kDa protein) (E1B-55K) (E1B-495R)
E1BS_ADE02E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K) (E1B-175R)
E310_ADE02Early E3B 10.4 kDa protein
E311_ADE02Early E3A 11.6 kDa glycoprotein
E312_ADE02Early E3A 12.5 kDa protein
E3145_ADE02Early E3B 14 kDa protein
E3B14_ADE02Early E3B 14.5 kDa protein
E3GL_ADE02Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
E411_ADE02Probable early E4 11 kDa protein
E413_ADE02Probable early E4 13 kDa protein
E417_ADE02Probable early E4 17 kDa protein
E431_ADE02Early 31 kDa protein
E434_ADE02Early E4 34 kDa protein
FIBP_ADE02Fiber protein (pIV)

pdb 1QHV  1QIU  1V1H  1V1I  2C9F 

HEX3_ADE02Peripentonal hexon-associated protein (Protein IIIa)
HEX8_ADE02Hexon-associated protein (Protein VIII) (pVIII)
HEX9_ADE02Hexon-associated protein (Protein IX) (pIX)
HEX_ADE02Hexon protein (Late protein 2)

pdb 1P2Z 

L100_ADE02Late 100 kDa protein
L2MU_ADE02Late L2 mu core protein (11 kDa core protein) (Protein X) (pX) (pMu)
L52_ADE02Late L1 52 kDa protein
PEN3_ADE02Penton protein (Penton base protein) (Virion component III) (pIII)

pdb 1X9P  1X9T  2BLD  2C6S  2C9F  2C9G 

PIV6_ADE02Minor capsid protein 6 (Minor capsid protein VI)

pdb 1AVP 

PIVA2_ADE02Maturation protein (Protein IVa2)
TERM_ADE02DNA terminal protein (Bellett protein) (pTP protein)
V33P_ADE0233 kDa phosphoprotein
VCO7_ADE02Major core protein (Protein VII) (pVII)
VCOM_ADE02Minor core protein (Protein V) (pV)
Y112_ADE02Uncharacterized protein F-112
Y115_ADE02Uncharacterized protein E-115
Y116_ADE02Uncharacterized 11.6 kDa early protein
Y121_ADE02Uncharacterized protein F-121
Y137_ADE02Uncharacterized protein B-137
Y168_ADE02Uncharacterized protein C-168
Y172_ADE02Uncharacterized protein D-172
Y215_ADE02Uncharacterized protein F-215
Y95_ADE02Uncharacterized protein E-95
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