Non-enveloped, round, T=1 icosahedral symmetry, about 25 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentamers.


Monopartite, circular, ssDNA genome of about 2300 bp.
The genome is replicated through double-stranded intermediates. A replication Rep-like protein would initiates rolling circle replication.


One mRNA is transcribed by cellular RNA polymerase II and encodes for three proteins: VP1, VP2 and VP3 probably through leaky scanning mechanism.



  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. Viral ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. Viral mRNAs are translated to produce viral proteins.
  5. Replication may be mediated by a Rep protein, and would occur by rolling circle replication producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

Apoptosis modulation

Chicken anemia virus VP3 protein induces apoptosis observed in CAV infection. Virus-induced apoptosis accounts for the severe depletion of cortical thymocytes and erythroblastoid cells in the bone marrow .

Matching UniProtKB/Swiss-Prot entries

16 entries grouped by strain (browse by keywords)

All proteins are shown (view only 15 complete proteome entries)

3 entries

Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) reference strain

CAPSD_CAVC1 Capsid protein (CA1) (Coat protein)
VP3_CAVC1 Apoptin
VP2_CAVC1 Dual specificity protein phosphatase VP2 (EC (EC

3 entries

Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)

CAPSD_CAVCA Capsid protein (CA1) (Coat protein)
VP3_CAVCA Apoptin
VP2_CAVCA Dual specificity protein phosphatase VP2 (EC (EC

3 entries

Chicken anemia virus (isolate Japan 82-2) (CAV)

CAPSD_CAV82 Capsid protein (CA1) (Coat protein)
VP3_CAV82 Apoptin
VP2_CAV82 Dual specificity protein phosphatase VP2 (EC (EC

3 entries

Chicken anemia virus (isolate USA 26p4) (CAV)

CAPSD_CAV26 Capsid protein (CA1) (Coat protein)
VP2_CAV26 Dual specificity protein phosphatase VP2 (EC (EC
VP3_CAV26 Apoptin

3 entries

Chicken anemia virus (isolate USA CIA-1) (CAV)

CAPSD_CAVCI Capsid protein (CA1) (Coat protein)
VP2_CAVCI Dual specificity protein phosphatase VP2 (EC (EC
VP3_CAVCI Apoptin

1 entry

Chicken anemia virus (isolate Australia) (CAV)

CAPSD_CAVAU Capsid protein (CA1) (Coat protein)