Circoviridae (taxid:39724)

VIRION

Non-enveloped, round, T=1 icosahedral symmetry, about 20 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentamers.

GENOME

Monopartite, circular, ssDNA genome of about 1.8 to 3.8 kb.
The genome is replicated through double-stranded intermediates. The replication (Rep) protein initiates rolling circle replication.

GENE EXPRESSION

One or two mRNAs encode for the Rep, capsid, and possibly others proteins. Some mRNA can undergo alternative splicing.

ENZYMES

Cress-type Endonuclease [Rep]

REPLICATION

NUCLEAR

Virus penetrates into the host cell.
Uncoating, the viral ssDNA genome penetrates into the nucleus.
Viral ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
Viral mRNAs are translated to produce viral proteins.
Replication may be mediated by a Rep protein, and would occur by rolling circle replication producing ssDNA genomes.
These newly synthesized ssDNA can either
a) be converted to dsDNA and serve as a template for transcription/replication
b) be encapsidated by capsid protein and form virions released by cell lysis.

DB LINKS

TAXONOMY Group II: ssDNA viruses

Realm:	Monodnaviria
Kingdom:	Shotokuvirae
Phylum:	Cressdnaviricota
Class:	Arfiviricetes
Order:	Cirlivirales
Family:	Circoviridae
Genus:	Circovirus Cyclovirus

VIRUS

Human associated cyclovirus 8
Porcine circovirus 1
Barbel circovirus
Bat associated circovirus 1
Bat associated circovirus 2
Bat associated circovirus 3
Bat associated circovirus 4
Bat associated circovirus 5
Bat associated circovirus 6
Bat associated circovirus 7
Bat associated circovirus 8
Bat associated circovirus 9
Bat associated cyclovirus 1
Bat associated cyclovirus 10
Bat associated cyclovirus 11
Bat associated cyclovirus 12
Bat associated cyclovirus 13
Bat associated cyclovirus 14
Bat associated cyclovirus 15
Bat associated cyclovirus 16
Bat associated cyclovirus 2
Bat associated cyclovirus 3
Bat associated cyclovirus 4
Bat associated cyclovirus 5
Bat associated cyclovirus 6
Bat associated cyclovirus 7
Bat associated cyclovirus 8
Bat associated cyclovirus 9
Beak and feather disease virus
Bovine associated cyclovirus 1
Canary circovirus
Canine circovirus
Chicken associated cyclovirus 1
Chimpanzee associated circovirus 1
Chimpanzee associated cyclovirus 1
Cockroach associated cyclovirus 1
Dragonfly associated cyclovirus 1
Dragonfly associated cyclovirus 2
Dragonfly associated cyclovirus 3
Dragonfly associated cyclovirus 4
Dragonfly associated cyclovirus 5
Dragonfly associated cyclovirus 6
Dragonfly associated cyclovirus 7
Dragonfly associated cyclovirus 8
Duck circovirus
European catfish circovirus
Feline associated cyclovirus 1
Finch circovirus
Goat associated cyclovirus 1
Goose circovirus
Gull circovirus
Horse associated cyclovirus 1
Human associated circovirus 1
Human associated cyclovirus 1
Human associated cyclovirus 10
Human associated cyclovirus 11
Human associated cyclovirus 12
Human associated cyclovirus 2
Human associated cyclovirus 3
Human associated cyclovirus 4
Human associated cyclovirus 5
Human associated cyclovirus 6
Human associated cyclovirus 7
Human associated cyclovirus 9
Mink circovirus
Mouse associated cyclovirus 1
Pigeon circovirus
Porcine circovirus 2
Porcine circovirus 3
Raven circovirus
Squirrel associated cyclovirus 1
Starling circovirus
Swan circovirus
Zebra finch circovirus

REFERENCE STRAINS Porcine circovirus 1
Sequence | Genome assembly | Proteome
Human cyclovirus 1
Sequence | Genome assembly | Proteome

Host

NATURAL HOSTS Birds and mammals.

TROPISM CAV: Chicken: Thymocytes, erythrobalstoid cells
Egg: embryonal tissues and eggshell membranes

INTERACTIONS Cell receptors:-
Host-virus interaction

Ecology and disease

GEOGRAPHY Worldwide.

ASSOCIATED DISEASES PCV-2: Postweaning multisystemic wasting syndrome
CAV: Chicken infectious anemia

TRANSMISSION Porcine circovirus: fecal-oral route
Chicken anemia virus: fecal-oral route

VACCINE PCV-2: Circumvent ® PCV (Intervet / S-P) and Ingelvac CircoFLEX ® (Boehringer Ingelheim).
Chicken anemia virus

ANTIVIRAL DRUGS

Host-virus interaction

Autophagy modulation

Cap protein of PCV2 induces activation of host autophagy in order to enhance its own replication .

Apoptosis modulation

PCV2 ORF3-encoded protein induces apoptosis by activating caspase-8 and caspase-3 pathways . This protein may be a candidate for PML bodies inhibition which is essential for nuclear virus replication in mammals.

These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna

(ModelArchive).

Acartia tonsa copepod circovirus taxid:1168547

Protein	ModelArchive
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20901
Uncharacterized protein	ma-jd-viral-49947

Anguilla anguilla circovirus taxid:1420600

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-63316
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20702

Artemia melana sponge associated circular genome taxid:1692243

Protein	ModelArchive
Putative spliced replication initiation protein	ma-jd-viral-20872

Avon-Heathcote Estuary associated circular virus 1 taxid:1618232

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28633
Replication-associated protein	ma-jd-viral-20932

Avon-Heathcote Estuary associated circular virus 11 taxid:1618234

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-39165
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20965

Avon-Heathcote Estuary associated circular virus 12 taxid:1618235

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-41440
Replication-associated protein	ma-jd-viral-20744

Avon-Heathcote Estuary associated circular virus 14 taxid:1618237

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28507
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20863

Avon-Heathcote Estuary associated circular virus 15 taxid:1618238

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27868
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20138

Avon-Heathcote Estuary associated circular virus 17 taxid:1618240

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28020
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20859

Avon-Heathcote Estuary associated circular virus 19 taxid:1618242

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-54884
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20818

Avon-Heathcote Estuary associated circular virus 20 taxid:1618244

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-30800
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20745

Avon-Heathcote Estuary associated circular virus 21 taxid:1618245

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28848
Replication-associated protein	ma-jd-viral-20856

Avon-Heathcote Estuary associated circular virus 22 taxid:1618246

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-48218
Replication-associated protein	ma-jd-viral-50674

Avon-Heathcote Estuary associated circular virus 23 taxid:1618247

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28653
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20755

Avon-Heathcote Estuary associated circular virus 26 taxid:1618250

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-63939
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20735

Avon-Heathcote Estuary associated circular virus 27 taxid:1618251

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27804
Replication-associated protein	ma-jd-viral-17095

Avon-Heathcote Estuary associated circular virus 28 taxid:1618252

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-41560
Replication-associated protein	ma-jd-viral-41439

Avon-Heathcote Estuary associated circular virus 29 taxid:1618253

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-56953
Replication-associated protein	ma-jd-viral-50691

Avon-Heathcote Estuary associated circular virus 5 taxid:1618256

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27558
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20682

Avon-Heathcote Estuary associated circular virus 6 taxid:1618257

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-53457
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20795

Avon-Heathcote Estuary associated circular virus 7 taxid:1618258

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-55034
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20767

Avon-Heathcote Estuary associated circular virus 8 taxid:1618259

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-53120
Replication-associated protein	ma-jd-viral-50675

Barbel circovirus taxid:759938

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27842
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20903

Bat circovirus POA/2012/VI taxid:1572239

Protein	ModelArchive
Capsid	ma-jd-viral-27483
Replicase	ma-jd-viral-17138

Calanoida sp. copepod associated circular virus taxid:1692244

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-08414
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20881

Callinectes ornatus blue crab associated circular virus taxid:1692245

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-38877
Putative replication initiation protein	ma-jd-viral-17109

Callinectes sapidus associated circular virus taxid:1692246

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-60604
Replication-associated protein	ma-jd-viral-20691

Canary circovirus taxid:142661

Protein	ModelArchive
Probable capsid protein	ma-jd-viral-28754
Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep)...	ma-jd-viral-20927

Canine circovirus taxid:1194757

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27432
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20747

Chimpanzee faeces associated circular DNA virus 1 taxid:1676184

Protein	ModelArchive
Capsid protein	ma-jd-viral-50905
Putative CP	ma-jd-viral-55732
Replication-associated protein	ma-jd-viral-33283

Cyclovirus NGchicken15/NGA/2009 taxid:942037

Protein	ModelArchive
Cap protein	ma-jd-viral-27174
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20740

Cyclovirus PKgoat11/PAK/2009 taxid:942034

Protein	ModelArchive
Cap protein	ma-jd-viral-27181
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20828

Cyclovirus PKgoat21/PAK/2009 taxid:942033

Protein	ModelArchive
Cap protein	ma-jd-viral-27171
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20716

Cyclovirus TsCyV-1_JP-NUBS-2014 taxid:1592764

Protein	ModelArchive
Capsid protein	ma-jd-viral-27192
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20807

Cyclovirus ZM36a taxid:1506568

Protein	ModelArchive
Capsid protein	ma-jd-viral-27187
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20672

Cyclovirus bat/USA/2009 taxid:942035

Protein	ModelArchive
Cap protein	ma-jd-viral-27184
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20851

Didemnum sp. Sea Squirt associated virus taxid:1692247

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28003
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20719

Dragonfly associated cyclovirus 1 taxid:1234879

Protein	ModelArchive
Capsid protein	ma-jd-viral-27188
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20940

Dragonfly associated cyclovirus 3 taxid:1234881

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27170
Replication-associated protein	ma-jd-viral-20785
Spliced replication-associated protein	ma-jd-viral-20936

Dragonfly associated cyclovirus 5 taxid:1234883

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27165
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20817

Dragonfly cyclovirus 2 taxid:1234880

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28875
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20804

Duck circovirus taxid:324685

Protein	ModelArchive
Capsid protein	ma-jd-viral-28851
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20938
Uncharacterized protein	ma-jd-viral-57969
Uncharacterized protein ORFC2	ma-jd-viral-42269

Farfantepenaeus duorarum pink shrimp associated circular virus taxid:1692248

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27280
Putative replication initiation protein	ma-jd-viral-20945

Feline cyclovirus taxid:1530454

Protein	ModelArchive
Capsid protein	ma-jd-viral-28014
Replication-associated protein	ma-jd-viral-20853

Fiddler Crab associated circular virus taxid:1692249

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28652
Putative replication initiation protein	ma-jd-viral-17115

Finch circovirus taxid:400122

Protein	ModelArchive
Capsid protein	ma-jd-viral-28761
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20866
Uncharacterized protein	ma-jd-viral-58828

Fur seal faeces associated circular DNA virus taxid:1353241

Protein	ModelArchive
Capsid protein	ma-jd-viral-27905
Replication-associated protein	ma-jd-viral-20968

Gammarus sp. amphipod associated circular virus taxid:1692250

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28018
Putative replication initiation protein	ma-jd-viral-17096

Goose circovirus taxid:146032

Protein	ModelArchive
Probable capsid protein	ma-jd-viral-28852
Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep)...	ma-jd-viral-20920
Uncharacterized protein ORFC2	ma-jd-viral-44063
Uncharacterized protein ORFV2	ma-jd-viral-34052

Gull circovirus taxid:400121

Protein	ModelArchive
Capsid protein	ma-jd-viral-28760
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20763
Uncharacterized protein	ma-jd-viral-29081

Hermit crab associated circular genome taxid:1692251

Protein	ModelArchive
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20673

Hermit crab associated circular virus taxid:1692252

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27964
Putative replication initiation protein	ma-jd-viral-17087

Human cyclovirus taxid:1455626

Protein	ModelArchive
Capsid protein	ma-jd-viral-28874
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20835

Human cyclovirus VS5700009 taxid:1345637

Protein	ModelArchive
Capsid protein	ma-jd-viral-27190
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20890

Indian encephalitis associated cyclovirus taxid:1755290

Protein	ModelArchive
Capsid protein	ma-jd-viral-27182
Replication-associated protein	ma-jd-viral-20704

Labidocera aestiva circovirus taxid:1173709

Protein	ModelArchive
Putative structural protein	ma-jd-viral-43922
Putative viral replication protein	ma-jd-viral-20727

Littorina sp. associated circular virus taxid:1692253

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-48878
Putative replication initiation protein	ma-jd-viral-17125

Lytechinus variegatus variable sea urchin associated circular virus taxid:1692254

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28769
Putative replication initiation protein	ma-jd-viral-17051

Marine snail associated circular virus taxid:1692255

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27963
Putative replication initiation protein	ma-jd-viral-17134

Mink circovirus taxid:1475143

Protein	ModelArchive
Cap protein (Capsid protein)	ma-jd-viral-27514
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20734

Mytilus sp. clam associated circular virus taxid:1692256

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27281
Putative replication initiation protein	ma-jd-viral-17060

Palaemonetes intermedius brackish grass shrimp associated circular virus taxid:1692257

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27962
Putative replication initiation protein	ma-jd-viral-17126

Palaemonetes kadiakensis Mississippi grass shrimp associated circular virus taxid:1692258

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-36122
Replication-associated protein	ma-jd-viral-20769

Palaemonetes sp. common grass shrimp associated circular virus taxid:1692259

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-53458
Putative replication initiation protein	ma-jd-viral-17089

Paramuricea placomus associated circular virus taxid:1692260

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-56688
Putative replication initiation protein	ma-jd-viral-16981

Penaeus monodon circovirus VN11 taxid:1419711

Protein	ModelArchive
Nonstructural protein 2	ma-jd-viral-33106
Replication-associated protein	ma-jd-viral-20894
Structural protein VP	ma-jd-viral-28530

Petrochirus diogenes giant hermit crab associated circular virus taxid:1692261

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-33198
Putative replication initiation protein	ma-jd-viral-20826

Pigeon circovirus taxid:126070

Protein	ModelArchive
Probable capsid protein	ma-jd-viral-28758
Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep)...	ma-jd-viral-20736
Uncharacterized protein ORFC2	ma-jd-viral-29716
Uncharacterized protein ORFC3	ma-jd-viral-63445
Uncharacterized protein ORFC4	ma-jd-viral-29225

Porcine circovirus 3 taxid:1868221

Protein	ModelArchive
Cap	ma-jd-viral-27790
Cap (Capsid)	ma-jd-viral-27790

Porcine circovirus type 1/2a taxid:720569

Protein	ModelArchive
Capsid	ma-jd-viral-27508
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20701

Porcine stool-associated circular virus 4 taxid:1475062

Protein	ModelArchive
Cap protein	ma-jd-viral-27902
Replication-associated protein	ma-jd-viral-20966

Porcine stool-associated circular virus 5 taxid:1475063

Protein	ModelArchive
Cap protein	ma-jd-viral-57412
Replication-associated protein	ma-jd-viral-20885

Primnoa pacifica coral associated circular virus taxid:1692262

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-34280
Replication-associated protein	ma-jd-viral-20137

Raven circovirus taxid:345250

Protein	ModelArchive
Capsid protein	ma-jd-viral-28759
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20758

Sicyonia brevirostris associated circular virus taxid:1692263

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-27882
Putative replication initiation protein	ma-jd-viral-38092

Starling circovirus taxid:349370

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28753
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20809
Uncharacterized protein	ma-jd-viral-39523

Swan circovirus taxid:459957

Protein	ModelArchive
Putative capsid protein	ma-jd-viral-28850
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20771

Zebra finch circovirus taxid:1642515

Protein	ModelArchive
Capsid protein	ma-jd-viral-28756
ORFC2	ma-jd-viral-29717
ORFV2	ma-jd-viral-42535
Replication-associated protein (ATP-dependent helicase Rep) (RepP)	ma-jd-viral-20778