| Process | Activity | Enzyme | Type | Rhea | Antiviral |
|---|---|---|---|---|---|
| Viral replication | Polymerase | RNA dependent RNA polymerase (RNA replicase) | | RHEA:21248 | Nucleoside analogue |
| DNA dependent DNA polymerase (DNA replicase) |  | RHEA:22508 | Nucleoside analogue | ||
| RNA dependent DNA polymerase (Reverse transcriptase) | | RHEA:22508 | Non-Nucleoside-RT inhibitors, Nucleoside-RT inhibitors | ||
| Initiation | Primase | | |||
| Protein-primed initiation of DNA replication | | ||||
| Protein-primed initiation of RNA replication (=VPG capping) | | ||||
| Cress-type Endonuclease | | ||||
| Ribozyme Endonuclease | | ||||
| Elongation | RNA-DNA duplex dependent endoribonuclease (RNase H) | | |||
| Topology | DNA topoisomerase | | |||
| DNA ligase | | ||||
| DNA helicase | | ||||
| RNA helicase | | ||||
| Holliday junction resolvase | | ||||
| Integrase | | ||||
| Nucleotide metabolism | Thymidine kinase | | RHEA:19129 | ||
| Thymidylate synthase | | RHEA:12104 | |||
| Thymidylate kinase | | RHEA:13517 | |||
| dUTP diphosphatase | | RHEA:10248 | |||
| dihydrofolate reductase | | RHEA:15009 | |||
| Ribonucleotide reductase | | RHEA:23252 | |||
| Regulation | E3 SUMO-protein ligase | | |||
| Viral transcription | Transcriptase | DNA dependent RNA polymerase (Transcriptase) | | RHEA:21248 | |
| RNA dependent RNA polymerase (RNA replicase/transcriptase) | | RHEA:21248 | |||
| Proofreading exoribonuclease (ExoN) | | ||||
| Picorna-type NTPase/helicase | | ||||
| Viral mRNA capping | Cell-type capping | | |||
| Alpha type capping | | ||||
| Nido-type capping | | ||||
| Mononega-type capping | | ||||
| VPG capping | | ||||
| Cap snatching | | ||||
| Toti-type cap snatching | | ||||
| FAD capping | | ||||
| PolyAdenylation | Poly(A) polymerase | | RHEA:11332 | ||
| RNA polymerase stuttering | | RHEA:11332 | |||
| Protein | Proteases | Cys/Ser-proteases | | ||
| Asp-proteases | | ||||
| Metallo-proteases | | ||||
| Asparagine-proteases | | ||||
| Post translational modification | Beta-1,6-N-acetyl-glucosaminyl transferase | ||||
| peptide N-myristoyl transferase | RHEA:15521 | ||||
| thiol oxidase | |||||
| Exit | Budding | Phospholipase | | ||
| Virion release | Neuraminidase | | Neuraminidase inhibitors | ||
| Viral-Host modulation | Anti-viral evasion | Polyuridine endonuclease | | ||
| Asparagine deaminase | |||||
| Ser/Thr kinase | |||||
| Tyr kinase | |||||
| Ubiquitin transferase=Ubiquitin-conjugating enzyme E2 | |||||
| ubiquitinyl hydrolase | |||||
| Tyr/ser/thr phosphatase | |||||
| 2',3'-cGAMP endonuclease | RHEA:59473 | ||||
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase | |||||
| ADP-ribose hydrolase | RHEA:24076 | ||||
| Host shut off | mRNA-decapping | ||||
| Other | Trans-prenyltransferase | ||||
| Deoxyuridine 5'-triphosphate nucleotidohydrolase | |||||
| Ribonucleoside-diphosphate reductase | |||||
| FAD-linked sulfhydryl oxidase |