Nanoviridae (taxid:251095)

VIRION

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Non-enveloped, round, T=1 icosahedral symmetry, about 18-19 nm in diameter.
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GENOME

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Multipartite ssDNA genome (+) composed of 6 to 8 circular segments about 1kb in size. Each ssDNA segment have a common stem-loop region and are encapsidated in a separate particle .
In addition to genomic DNA, satellite-like DNA are commonly found, usually encoding for Rep proteins. These satellite-Rep proteins are only able to initiate replication of their genomic DNA, unlike genomic Rep which promotes replication of all 6-8 viral genomic ssDNAs.

GENE EXPRESSION

Each ssDNA genome segment is monocistronic. In rare cases a gene encodes for two overlapping ORFs.

ENZYMES

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors.
  4. Bidirectional dsDNA transcription from the IR promoter produces viral mRNAs and translation of viral proteins.
  5. Replication is initiated by cleavage of the (+)strand by REP, and occurs by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by CP and form virions that will be released in the extracellular space. c) be transported outside the nucleus, to a neighboring cell through plasmodesmata (cell-cell movement) with the help of viral movement proteins.

Host-virus interaction

Cell-cycle modulation

Nanoviruses Clink protein is probably involved in binding and inhibiting host retinoblastoma protein. Inhibition of retinoblastoma protein induces transition from the G1 to S phase for optimal replication conditions.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

51 entries grouped by protein

7 entries

Capsid protein (CP) (Coat protein)

Select_allDeselect_all
CAPSD_BBTVA
Banana bunchy top virus (isolate Autralia) (BBTV) reference strain
CAPSD_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
CAPSD_SCSVF
Subterranean clover stunt virus (strain F) (SCSV) reference strain
CAPSD_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)
CAPSD_MDV1
Milk vetch dwarf virus (isolate N) (MDV)
CAPSD_MDV9
Milk vetch dwarf virus (isolate 9) (MDV)
CAPSD_SCSVJ
Subterranean clover stunt virus (strain J) (SCSV)

5 entries

Cell cycle link protein (Clink)

Select_allDeselect_all
CLINK_BBTVA
Banana bunchy top virus (isolate Autralia) (BBTV) reference strain
CLINK_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
CLINK_SCSVF
Subterranean clover stunt virus (strain F) (SCSV) reference strain
CLINK_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)
CLINK_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

5 entries

Master replication protein (M-Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-)

Select_allDeselect_all
MREP_BBTVA
Banana bunchy top virus (isolate Autralia) (BBTV) reference strain
MREP_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain

Master replication protein (M-Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase C2) (Replication-associated protein 2) (Rep2)

MREP_SCSVF
Subterranean clover stunt virus (strain F) (SCSV) reference strain
MREP_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)

Master replication protein (M-Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase C2) (Replication-associated protein 2) (Rep2)

MREP_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

5 entries

Putative movement protein (MP)

Select_allDeselect_all
MVP_BBTVA
Banana bunchy top virus (isolate Autralia) (BBTV) reference strain

Movement and RNA silencing protein (MP)

MVP_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
MVP_SCSVF
Subterranean clover stunt virus (strain F) (SCSV) reference strain
MVP_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)
MVP_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

5 entries

Putative nuclear shuttle protein

Select_allDeselect_all
NSP_BBTVA
Banana bunchy top virus (isolate Autralia) (BBTV) reference strain
NSP_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
NSP_SCSVF
Subterranean clover stunt virus (strain F) (SCSV) reference strain
NSP_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)
NSP_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

3 entries

Para-Rep C1 (Rep1) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase C1) (Replication-associated protein of non-essential DNA C1)

Select_allDeselect_all
REP1_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
REP1_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)
REP1_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

Para-Rep C1 (Rep1) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (Replication-associated protein of non-essential DNA C1)

1 entry

Para-Rep C10 (Rep10) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (Replication-associated protein of non-essential DNA C10)

REP10_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

2 entries

Para-Rep C2 (Rep2) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (Replication-associated protein of non-essential DNA C2)

Select_allDeselect_all
REP2_SCSVF
Subterranean clover stunt virus (strain F) (SCSV) reference strain
REP2_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

1 entry

Para-Rep C3 (Rep3) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (Replication-associated protein of non-essential DNA C3)

REP3_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

1 entry

Para-Rep C6 (Rep6) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (Replication-associated protein of non-essential DNA C6)

REP6_SCSVF
Subterranean clover stunt virus (strain F) (SCSV) reference strain

2 entries

Para-Rep C7 (Rep7) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase C7) (Replication-associated protein of non-essential DNA C7)

Select_allDeselect_all
REP7_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
REP7_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)

2 entries

Para-Rep C9 (Rep9) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase C9) (Replication-associated protein of non-essential DNA C9)

Select_allDeselect_all
REP9_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
REP9_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)

4 entries

Protein U1

Select_allDeselect_all
U1_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
U1_SCSVF
Subterranean clover stunt virus (strain F) (SCSV) reference strain
U1_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)
U1_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

3 entries

Protein U2

Select_allDeselect_all
U2_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
U2_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)
U2_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

1 entry

Uncharacterized protein U3

U3_BBTVA
Banana bunchy top virus (isolate Autralia) (BBTV) reference strain

3 entries

Protein U4

Select_allDeselect_all
U4_FBNY1
Faba bean necrotic yellows virus (isolate Egyptian EV1-93) (FBNYV) reference strain
U4_FBNY2
Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV)
U4_MDV1
Milk vetch dwarf virus (isolate N) (MDV)

1 entry

Uncharacterized 5 kDa protein in M-Rep ORF (Uncharacterized protein U5)

U5_BBTVA
Banana bunchy top virus (isolate Autralia) (BBTV) reference strain
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Babuvirus abacae taxid:438782

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-28879
Putative cell-cycle link protein ma-jd-viral-43435
Putative movement protein ma-jd-viral-62611
Putative nuclear shuttle protein ma-jd-viral-27294
Putative replicase protein ma-jd-viral-17084

Black medic leaf roll virus taxid:2038729

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-27227
Cell cycle link protein ma-jd-viral-46177
Master rplication initiator protein ma-jd-viral-17066
Movement protein ma-jd-viral-63676
Putative nuclear shuttle protein ma-jd-viral-27288
U1 protein ma-jd-viral-03427
U2 protein ma-jd-viral-00433
U4 protein ma-jd-viral-45560

Faba bean necrotic stunt virus taxid:283824

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-27224
Cell-cycle link protein (Clink) ma-jd-viral-46172
Master-replication initiator protein ma-jd-viral-17103
Movement protein ma-jd-viral-63675
Putative nuclear shuttle protein ma-jd-viral-27291
U1 protein ma-jd-viral-03432
U2 protein ma-jd-viral-00428
U4 protein ma-jd-viral-45555

Faba bean necrotic yellows virus taxid:59817

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-27219

Faba bean necrotic yellows virus (isolate Egyptian EV1-93) taxid:291603

Protein ModelArchive
Capsid protein (CP) (Coat protein) ma-jd-viral-27219
Cell cycle link protein (Clink) ma-jd-viral-46174
Master replication protein (M-Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase C2) (Replication-associated protein 2)... ma-jd-viral-17091
Protein U1 ma-jd-viral-03426
Protein U2 ma-jd-viral-00430
Protein U4 ma-jd-viral-45562
Putative movement protein (MP) ma-jd-viral-63674
Putative nuclear shuttle protein ma-jd-viral-27290

Milk vetch dwarf virus taxid:67585

Protein ModelArchive
Movement protein ma-jd-viral-63678

Milk vetch dwarf virus (isolate N) taxid:291605

Protein ModelArchive
Capsid protein (CP) (Coat protein) ma-jd-viral-27225
Cell cycle link protein (Clink) ma-jd-viral-46173
Protein U1 ma-jd-viral-03422
Protein U2 ma-jd-viral-00431
Putative movement protein (MP) ma-jd-viral-63678
Putative nuclear shuttle protein ma-jd-viral-27296

Pea necrotic yellow dwarf virus taxid:753670

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-27220
Clink ma-jd-viral-46178
Master replication initiator protein ma-jd-viral-17071
Movement protein ma-jd-viral-63670
Putative nuclear shuttle protein ma-jd-viral-27293
U1 protein ma-jd-viral-03425
U2 protein ma-jd-viral-00427
U4 protein ma-jd-viral-45558

Pea yellow stunt virus taxid:1436892

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-27222
Cell cycle link protein ma-jd-viral-46179
Master replication initiator protein ma-jd-viral-17093
Movement protein ma-jd-viral-63677
Putative nuclear shuttle protein ma-jd-viral-27289
U1 protein ma-jd-viral-03424
U2 protein ma-jd-viral-00432
U4 protein ma-jd-viral-45557