Ilarvirus (taxid:12316)

VIRION

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Non-enveloped, quasi-spherical virion about 29nm in diameter with T=3 icosahedral symmetry composed of 180 coat proteins: 12 pentamers and 20 hexamers.

GENOME

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Segmented, tripartite linear ssRNA(+) genome composed of RNA1, RNA2, RNA3. Each genomic segment has a 3' tRNA-like structure and a 5'cap.

GENE EXPRESSION

Genomic RNA serves as messenger RNAs. RNA1 and RNA2 encode respectively proteins 1a and 2a, both involved in genome replication and internal transcription of sgRNA4 from the minus-strand copy of RNA3. RNA3 and sgRNA4 are translated respectively into movement and capsid proteins. ORF2b encodes a viral suppressor of RNA silencing (VSR) and is expressed as a subgenomic RNA (sgRNA4A).

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Expression of protein 1a and 2a to produce replication proteins.
  4. Replication occurs in viral factories made of membrane vesicles derived from the ER (spherules). A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA4 is translated producing capsid proteins.
  7. Assembly of new virus particles.
  8. Viral movement protein triggers the formation of tubular structures that mediate virion cell-to-cell transfer via a tubule-guided mechanism.

Host-virus interaction

Suppression of RNA silencing

Tobacco streak virus protein 2b possibly acts as a suppressor of RNA silencing.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

5 entries grouped by protein

1 entry

Replication protein 1a

1A_TOBSV
Tobacco streak virus (strain WC) (TSV) reference strain

1 entry

Suppressor of silencing 2b (Protein 2b)

2B_TOBSV
Tobacco streak virus (strain WC) (TSV) reference strain

1 entry

Capsid protein (CP) (Coat protein)

CAPSD_TOBSV
Tobacco streak virus (strain WC) (TSV) reference strain

1 entry

Movement protein (MP) (Protein 3A)

MVP_TOBSV
Tobacco streak virus (strain WC) (TSV) reference strain

1 entry

RNA-directed RNA polymerase 2a (2a pol) (EC 2.7.7.48) (2a polymerase)

RDRP_TOBSV
Tobacco streak virus (strain WC) (TSV) reference strain
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Ageratum latent virus taxid:1386090

Protein ModelArchive
2b protein ma-jd-viral-43708
Coat protein ma-jd-viral-27550
Movement protein (Protein 3A) ma-jd-viral-27844
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19121
Replication protein 1a ma-jd-viral-38456

Apple mosaic virus taxid:12319

Protein ModelArchive
Coat protein ma-jd-viral-27837
Movement protein (Protein 3A) ma-jd-viral-28738

Blackberry chlorotic ringspot virus taxid:339420

Protein ModelArchive
Coat protein ma-jd-viral-27553
Movement protein (Protein 3A) ma-jd-viral-27846
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19122
Replication protein 1a ma-jd-viral-38461
p2b protein ma-jd-viral-43705

Blueberry shock virus taxid:747056

Protein ModelArchive
Coat protein ma-jd-viral-27835
Movement protein (Protein 3A) ma-jd-viral-28740
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19217
Replication protein 1a ma-jd-viral-38437

Citrus leaf rugose virus taxid:37126

Protein ModelArchive
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19248

Elm mottle virus taxid:56486

Protein ModelArchive
Coat protein ma-jd-viral-27907
Movement protein (Protein 3A) ma-jd-viral-28445
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19249
Replication protein 1a ma-jd-viral-38470

Fragaria chiloensis latent virus taxid:255238

Protein ModelArchive
Coat protein ma-jd-viral-28956
Movement protein (Protein 3A) ma-jd-viral-27918
ORF 3 ma-jd-viral-48155
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19220
Replication protein 1a ma-jd-viral-38476
Secreted protein ma-jd-viral-31942

Lilac leaf chlorosis virus taxid:722755

Protein ModelArchive
Coat protein ma-jd-viral-27834
Movement protein (Protein 3A) ma-jd-viral-28741
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19219
Replication protein 1a ma-jd-viral-38468

Parietaria mottle virus taxid:64958

Protein ModelArchive
Coat protein ma-jd-viral-27551
Movement protein (Protein 3A) ma-jd-viral-27847

Privet ringspot virus taxid:2169960

Protein ModelArchive
2b protein ma-jd-viral-43706
Coat protein ma-jd-viral-27552
Movement protein (Protein 3A) ma-jd-viral-27845
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19124
Replication protein 1a ma-jd-viral-38474

Prune dwarf virus taxid:33760

Protein ModelArchive
Replication protein 1a ma-jd-viral-38472

Prunus necrotic ringspot virus taxid:37733

Protein ModelArchive
Coat protein ma-jd-viral-27833
Movement protein (Protein 3A) ma-jd-viral-28742

Spinach latent virus taxid:42680

Protein ModelArchive
Movement protein (Protein 3A) ma-jd-viral-28444
Putative 2b protein ma-jd-viral-44391
Putative coat protein ma-jd-viral-27908
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19250
Replication protein 1a ma-jd-viral-38475

Strawberry necrotic shock virus taxid:243563

Protein ModelArchive
2b protein ma-jd-viral-43707
RNA-directed RNA polymerase 2a (EC 2.7.7.48) ma-jd-viral-19125

Tobacco streak virus (strain WC) taxid:12318

Protein ModelArchive
RNA-directed RNA polymerase 2a (2a pol) (EC 2.7.7.48) (2a polymerase) ma-jd-viral-19123
Suppressor of silencing 2b (Protein 2b) ma-jd-viral-43710