Avipoxvirus

VIRION

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Enveloped, brick-shpaed 330x280x200nm. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome about 300kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Canarypox virus strain ATCC VR111 genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Apoptosis modulation

FPV039 inhibits apoptosis by sequestering and inactivating multiple proapoptotic Bcl-2 proteins, including Bak and Bax .

Matching UniProtKB/Swiss-Prot entries

156 entries grouped by strain (browse by keywords)

149 entries

Fowlpox virus (strain NVSL) (FPV) reference strain

Select_allDeselect_all
V007_FOWPN Uncharacterized protein FPV007/FPV254
V093_FOWPN Probable FAD-linked sulfhydryl oxidase FPV093 (EC 1.8.3.2)
V251_FOWPN Uncharacterized serpin-like protein FPV251
V060_FOWPN Putative CC-type chemokine FPV060
V033_FOWPN Soluble NSF attachment protein homolog FPV033
V234_FOWPN Putative ankyrin repeat protein FPV234 (BamHI-ORF12/ORF13)
V127_FOWPN Protein FPV127
V243_FOWPN Putative ankyrin repeat protein FPV243
V220_FOWPN Uncharacterized protein FPV220
V222_FOWPN Putative ankyrin repeat protein FPV222
V002_FOWPN Uncharacterized protein FPV002/FPV259
V009_FOWPN Uncharacterized protein FPV009/FPV252 (ORF b)
V249_FOWPN Uncharacterized protein FPV249 (BamHI-ORF5)
RP132_FOWPN DNA-directed RNA polymerase 132 kDa polypeptide (EC 2.7.7.6)
RP147_FOWPN DNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6)
RP18_FOWPN DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6)
RP19_FOWPN DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6)
RP22_FOWPN DNA-directed RNA polymerase 22 kDa subunit (EC 2.7.7.6)
RP35_FOWPN DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6)
V018_FOWPN Putative ankyrin repeat protein FPV018
V162_FOWPN Putative ankyrin repeat protein FPV162
V012_FOWPN Putative ankyrin repeat protein FPV012
VLTF3_FOWPN Viral late gene transcription factor 3 (VLTF-3)
RP07_FOWPN DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
P4A_FOWPN Major core protein 4a precursor (p4a) (Virion core protein 4a precursor)
RPO5_FOWPN DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6)
V014_FOWPN Putative ankyrin repeat protein FPV014
V022_FOWPN Putative ankyrin repeat protein FPV022
V044_FOWPN Uncharacterized serpin-like protein FPV044
V248_FOWPN Uncharacterized protein FPV248 (BamHI-ORF6)
V029_FOWPN Putative peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29)
V003_FOWPN Putative C-type lectin protein FPV003/FPV258
V045_FOWPN Uncharacterized protein FPV045
V219_FOWPN Putative ankyrin repeat protein FPV219
V244_FOWPN Putative ankyrin repeat protein FPV244
V063_FOWPN Protein FPV063 (FPLeft)
V130_FOWPN Protein FPV130
VLTF2_FOWPN Viral late gene transcription factor 2 (VLTF-2) (Trans-activator protein A1)
V023_FOWPN Putative ankyrin repeat protein FPV023
V230_FOWPN Putative ankyrin repeat protein FPV230
V216_FOWPN Putative ankyrin repeat protein FPV216
V233_FOWPN Putative ankyrin repeat protein FPV233
V198_FOWPN Putative C-type lectin protein FPV198
V236_FOWPN Uncharacterized protein FPV236 (BamHI-ORF10)
V245_FOWPN Putative ankyrin repeat protein FPV245
V246_FOWPN Putative ankyrin repeat protein FPV246
V242_FOWPN Putative ankyrin repeat protein FPV242
V027_FOWPN G-protein coupled receptor homolog FPV027
V061_FOWPN Putative CC-type chemokine FPV061
V040_FOWPN Uncharacterized serpin-like protein FPV040
V011_FOWPN Soluble NSF attachment protein homolog FPV011
V195_FOWPN Protein FPV195
V010_FOWPN Uncharacterized serpin-like protein FPV010
UNG_FOWPN Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
V026_FOWPN Putative ankyrin repeat protein FPV026
V117_FOWPN Protein FPV117
V111_FOWPN Probable serine/threonine-protein kinase FPV111 (EC 2.7.11.1)
V206_FOWPN G-protein coupled receptor homolog FPV206
VLTF1_FOWPN Late transcription factor 1 (VLTF-1)
V240_FOWPN Putative ankyrin repeat protein FPV240 (BamHI-ORF7)
V235_FOWPN Putative protein FPV235 (BamHI-ORF11)
V055_FOWPN Putative Ig-like V-type domain-containing protein FPV055 (Protein Y)
V001_FOWPN Putative C-type lectin protein FPV001/FPV260
V034_FOWPN Putative ankyrin repeat protein FPV034
V042_FOWPN Uncharacterized protein FPV042
V021_FOWPN G-protein coupled receptor homolog FPV021
V223_FOWPN Putative ankyrin repeat protein FPV223
V250_FOWPN Uncharacterized protein FPV250 (BamHI-ORF4)
V232_FOWPN Putative ankyrin repeat protein FPV232
V006_FOWPN Uncharacterized protein FPV006/FPV255 (BamHI-ORF1)
V024_FOWPN Putative ankyrin repeat protein FPV024
V031_FOWPN Putative ankyrin repeat protein FPV031
V224_FOWPN Putative ankyrin repeat protein FPV224
V239_FOWPN Putative C-type lectin protein FPV239 (BamHI-ORF8)
V228_FOWPN Putative ankyrin repeat protein FPV228
V238_FOWPN Uncharacterized protein FPV238 (ORF f)
V227_FOWPN Putative ankyrin repeat protein FPV227
V211_FOWPN Probable growth factor FPV211
V237_FOWPN Uncharacterized protein FPV237 (BamHI-ORF9)
VP8_FOWPN Core protein VP8 (25 kDa major core protein) (L4 core protein) (P25K)
V008_FOWPN Putative C-type lectin protein FPV008/FPV253 (BamHI-ORF2)
V226_FOWPN Probable serine/threonine-protein kinase FPV226 (EC 2.7.11.1)
VP35_FOWPN Immunodominant envelope protein p35 (Ag35) (Virion envelope protein p35)
V204_FOWPN Uncharacterized serpin-like protein FPV204
V155_FOWPN Putative ankyrin repeat protein FPV115
V212_FOWPN Probable serine/threonine-protein kinase FPV212 (EC 2.7.11.1)
V241_FOWPN Putative ankyrin repeat protein FPV241
F17_FOWPN Phosphoprotein F17
A9_FOWPN Protein A9 homolog
F12_FOWPN Virion release protein (Protein F12 homolog)
P4B_FOWPN Major core protein 4b (Virion core protein 4b) (p4b)
A17_FOWPN Virion membrane protein A17 precursor homolog
A16_FOWPN Virion membrane protein A16 homolog
DNLI_FOWPN DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])
A15_FOWPN Core protein A15 homolog
A6_FOWPN Protein A6 homolog
D5_FOWPN Primase D5 (EC 3.6.4.-)
D9_FOWPN Putative Nudix hydrolase FPV054 (EC 3.6.-.-)
A14_FOWPN Virion membrane protein A14 homolog
A18_FOWPN Transcript termination protein A18 (EC 3.6.4.-)
A21_FOWPN Virion membrane protein A21 homolog
A28_FOWPN Envelope protein A28 homolog (Protein FPV192)
3BHS_FOWPN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase (3-beta-HSD) [Includes: ...
D3_FOWPN 27 kDa core protein
E6_FOWPN Protein E6 homolog
E11_FOWPN Protein E11 homolog
DPOL_FOWPN DNA polymerase (EC 2.7.7.7)
A19_FOWPN Protein A19 homolog
A30_FOWPN Protein A30 homolog
DUSP_FOWPN Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)
A11_FOWPN Protein A11 homolog
ETF1_FOWPN Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small ...
F11_FOWPN Protein F11 homolog
I2_FOWPN Protein I2 homolog (Protein FPV089)
KITH_FOWPN Thymidine kinase (EC 2.7.1.21)
MP44_FOWPN Probable metalloendopeptidase G1-type (EC 3.4.24.-)
E2_FOWPN Protein E2 homolog
DUT_FOWPN Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
ETF2_FOWPN Early transcription factor 82 kDa subunit (ETF large subunit)
MCE_FOWPN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) polymerase regulatory ...
I5L_FOWPN Protein I5 homolog
DCK2_FOWPN Probable deoxycytidine kinase FPV151 (dCK) (EC 2.7.1.74)
D10_FOWPN mRNA-decapping protein D10 (EC 3.1.3.-)
A13_FOWPN Virion membrane protein A13 homolog
DCK1_FOWPN Probable deoxycytidine kinase FPV059 (dCK) (EC 2.7.1.74)
G3_FOWPN Protein G3 homolog (Protein FPV078)
J1_FOWPN Protein J1 homolog (Protein FPV133)
J5_FOWPN Protein J5 homolog (FPV136)
ARBH_FOWPN Apoptosis regulator Bcl-2 homolog
F13_FOWPN Envelope protein F13 homolog (43 kDa protein) (p43K)
F15_FOWPN Protein F15
L2_FOWPN Protein FPV129
D13_FOWPN Scaffold protein (62 kDa protein) (D13 ortholog) (N3L protein) (Rifampicin resistance protein)
I6_FOWPN Telomere-binding protein I6 homolog (Protein FPV084)
L1_FOWPN Protein L1 homolog (Virion membrane protein M25)
L5_FOWPN L5 homolog (Protein FPV132)
MCES_FOWPN mRNA-capping enzyme small subunit (mRNA (guanine-N(7))-methyltransferase) (EC 2.1.1.56) (mRNA cap ...
NTP1_FOWPN Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
H7_FOWPN Late protein H7 homolog
I1_FOWPN Telomere-binding protein I1 homolog (Protein FPV90)
MCEL_FOWPN mRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) (VTF large subunit) ...
PAP1_FOWPN Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L) (VP55)
V231_FOWPN Putative ankyrin repeat protein FPV231
V218_FOWPN Putative ankyrin repeat protein FPV218
O1_FOWPN Protein O1 homolog (Protein FPV091)
NPH2_FOWPN RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside ...
RAP94_FOWPN RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated ...
I7_FOWPN Core protease I7 homolog (EC 3.4.22.-) (Protein FPV083)
RUVV_FOWPN Holliday junction resolvase (EC 3.1.-.-)

3 entries

Canarypox virus (CNPV) reference strain

Select_allDeselect_all
PAP1_CNPV Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
ARBH_CNPV Apoptosis regulator Bcl-2 homolog (vBcl-2)
D3_CNPV 27 kDa core protein

4 entries

Fowlpox virus (FPV)

Select_allDeselect_all
V127_FOWPV Protein FPV127
D3_FOWPV 27 kDa core protein
PAP1_FOWPV Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L) (VP55)
D13_FOWPV Scaffold protein (62 kDa protein) (D13 ortholog) (N3L protein) (Rifampicin resistance protein)