Avipoxvirus

VIRION

Enveloped, brick-shpaed 330x280x200nm. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome about 300kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Canarypox virus strain ATCC VR111 genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Apoptosis modulation

FPV039 inhibits apoptosis by sequestering and inactivating multiple proapoptotic Bcl-2 proteins, including Bak and Bax .

Matching UniProtKB/Swiss-Prot entries

152 entries grouped by strain (browse by keywords)

149 entries

Fowlpox virus (strain NVSL) (FPV) reference strain

Select_allDeselect_all
RP07_FOWPN DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
RP132_FOWPN DNA-directed RNA polymerase 132 kDa polypeptide (EC 2.7.7.6)
RP35_FOWPN DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6)
RP19_FOWPN DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6)
RP22_FOWPN DNA-directed RNA polymerase 22 kDa subunit (EC 2.7.7.6)
RP147_FOWPN DNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6)
RP18_FOWPN DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6)
RPO5_FOWPN DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6)
RUVV_FOWPN Holliday junction resolvase (EC 3.1.-.-)
V011_FOWPN Soluble NSF attachment protein homolog FPV011
V021_FOWPN G-protein coupled receptor homolog FPV021
V029_FOWPN Putative peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29)
V033_FOWPN Soluble NSF attachment protein homolog FPV033
V034_FOWPN Putative ankyrin repeat protein FPV034
V111_FOWPN Probable serine/threonine-protein kinase FPV111 (EC 2.7.11.1)
V155_FOWPN Putative ankyrin repeat protein FPV115
V162_FOWPN Putative ankyrin repeat protein FPV162
VLTF2_FOWPN Viral late gene transcription factor 2 (VLTF-2) (Trans-activator protein A1)
VLTF3_FOWPN Viral late gene transcription factor 3 (VLTF-3)
VP8_FOWPN Core protein VP8 (25 kDa major core protein) (L4 core protein) (P25K)
VLTF1_FOWPN Late transcription factor 1 (VLTF-1)
V003_FOWPN Putative C-type lectin protein FPV003/FPV258
V007_FOWPN Uncharacterized protein FPV007/FPV254
V008_FOWPN Putative C-type lectin protein FPV008/FPV253 (BamHI-ORF2)
V127_FOWPN Protein FPV127
V195_FOWPN Protein FPV195
V198_FOWPN Putative C-type lectin protein FPV198
V212_FOWPN Probable serine/threonine-protein kinase FPV212 (EC 2.7.11.1)
V218_FOWPN Putative ankyrin repeat protein FPV218
V219_FOWPN Putative ankyrin repeat protein FPV219
V222_FOWPN Putative ankyrin repeat protein FPV222
V224_FOWPN Putative ankyrin repeat protein FPV224
V226_FOWPN Probable serine/threonine-protein kinase FPV226 (EC 2.7.11.1)
V236_FOWPN Uncharacterized protein FPV236 (BamHI-ORF10)
V249_FOWPN Uncharacterized protein FPV249 (BamHI-ORF5)
V251_FOWPN Uncharacterized serpin-like protein FPV251
VP35_FOWPN Immunodominant envelope protein p35 (Ag35) (Virion envelope protein p35)
V211_FOWPN Probable growth factor FPV211
V216_FOWPN Putative ankyrin repeat protein FPV216
V220_FOWPN Uncharacterized protein FPV220
V223_FOWPN Putative ankyrin repeat protein FPV223
V227_FOWPN Putative ankyrin repeat protein FPV227
V230_FOWPN Putative ankyrin repeat protein FPV230
V231_FOWPN Putative ankyrin repeat protein FPV231
V232_FOWPN Putative ankyrin repeat protein FPV232
V233_FOWPN Putative ankyrin repeat protein FPV233
V234_FOWPN Putative ankyrin repeat protein FPV234 (BamHI-ORF12/ORF13)
V238_FOWPN Uncharacterized protein FPV238 (ORF f)
V239_FOWPN Putative C-type lectin protein FPV239 (BamHI-ORF8)
V240_FOWPN Putative ankyrin repeat protein FPV240 (BamHI-ORF7)
V242_FOWPN Putative ankyrin repeat protein FPV242
V248_FOWPN Uncharacterized protein FPV248 (BamHI-ORF6)
DUSP_FOWPN Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)
MP44_FOWPN Probable metalloendopeptidase G1-type (EC 3.4.24.-)
L1_FOWPN Protein L1 homolog (Virion membrane protein M25)
O1_FOWPN Protein O1 homolog (Protein FPV091)
NTP1_FOWPN Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
L5_FOWPN L5 homolog (Protein FPV132)
I5L_FOWPN Protein I5 homolog
I7_FOWPN Core protease I7 homolog (EC 3.4.22.-) (Protein FPV083)
L2_FOWPN Protein FPV129
P4A_FOWPN Major core protein 4a precursor (p4a) (Virion core protein 4a precursor)
PAP1_FOWPN Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L) (VP55)
P4B_FOWPN Major core protein 4b (Virion core protein 4b) (p4b)
MCES_FOWPN mRNA-capping enzyme small subunit (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.56) (mRNA cap ...
MCE_FOWPN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) polymerase regulatory ...
NPH2_FOWPN RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside ...
J1_FOWPN Protein J1 homolog (Protein FPV133)
MCEL_FOWPN mRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) (VTF large subunit) ...
I1_FOWPN Telomere-binding protein I1 homolog (Protein FPV90)
I2_FOWPN Protein I2 homolog (Protein FPV089)
I6_FOWPN Telomere-binding protein I6 homolog (Protein FPV084)
J5_FOWPN Protein J5 homolog (FPV136)
3BHS_FOWPN 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase (3-beta-HSD) [Includes: ...
A11_FOWPN Protein A11 homolog
A14_FOWPN Virion membrane protein A14 homolog
A18_FOWPN Transcript termination protein A18 (EC 3.6.4.-)
ETF1_FOWPN Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small ...
F17_FOWPN Core phosphoprotein F17
ETF2_FOWPN Early transcription factor 82 kDa subunit (ETF large subunit)
F11_FOWPN Protein F11 homolog
F12_FOWPN Virion release protein (Protein F12 homolog)
G3_FOWPN Protein G3 homolog (Protein FPV078)
D3_FOWPN 27 kDa core protein
D5_FOWPN Primase D5 (EC 3.6.4.-)
D10_FOWPN mRNA-decapping protein D10 (EC 3.1.3.-)
DCK2_FOWPN Probable deoxycytidine kinase FPV151 (dCK) (EC 2.7.1.74)
DCK1_FOWPN Probable deoxycytidine kinase FPV059 (dCK) (EC 2.7.1.74)
H7_FOWPN Late protein H7 homolog
A6_FOWPN Protein A6 homolog
A21_FOWPN Virion membrane protein A21 homolog
A28_FOWPN Envelope protein A28 homolog (Protein FPV192)
A30_FOWPN Protein A30 homolog
A9_FOWPN Protein A9 homolog
A13_FOWPN Virion membrane protein A13 homolog
A15_FOWPN Core protein A15 homolog
A16_FOWPN Virion membrane protein A16 homolog
A17_FOWPN Virion membrane protein A17 precursor homolog
A19_FOWPN Protein A19 homolog
DPOL_FOWPN DNA polymerase (EC 2.7.7.7)
E6_FOWPN Protein E6 homolog
E2_FOWPN Protein E2 homolog
DNLI_FOWPN DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])
D13_FOWPN Scaffold protein D13 ortholog (62 kDa protein) (Rifampicin resistance protein)
D9_FOWPN Putative Nudix hydrolase FPV054 (EC 3.6.-.-)
E11_FOWPN Protein E11 homolog
DUT_FOWPN Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
F15_FOWPN Protein F15
F13_FOWPN Envelope protein F13 homolog (43 kDa protein) (p43K)
ARBH_FOWPN Apoptosis regulator Bcl-2 homolog
V001_FOWPN Putative C-type lectin protein FPV001/FPV260
V010_FOWPN Uncharacterized serpin-like protein FPV010
V012_FOWPN Putative ankyrin repeat protein FPV012
V014_FOWPN Putative ankyrin repeat protein FPV014
V042_FOWPN Uncharacterized protein FPV042
V044_FOWPN Uncharacterized serpin-like protein FPV044
V060_FOWPN Putative CC-type chemokine FPV060
V063_FOWPN Protein FPV063 (FPLeft)
V093_FOWPN Probable FAD-linked sulfhydryl oxidase FPV093 (EC 1.8.3.2)
V117_FOWPN Protein FPV117
UNG_FOWPN Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
V002_FOWPN Uncharacterized protein FPV002/FPV259
V006_FOWPN Uncharacterized protein FPV006/FPV255 (BamHI-ORF1)
V009_FOWPN Uncharacterized protein FPV009/FPV252 (ORF b)
V018_FOWPN Putative ankyrin repeat protein FPV018
V022_FOWPN Putative ankyrin repeat protein FPV022
V023_FOWPN Putative ankyrin repeat protein FPV023
V024_FOWPN Putative ankyrin repeat protein FPV024
V026_FOWPN Putative ankyrin repeat protein FPV026
V027_FOWPN G-protein coupled receptor homolog FPV027
V031_FOWPN Putative ankyrin repeat protein FPV031
V040_FOWPN Uncharacterized serpin-like protein FPV040
V045_FOWPN Uncharacterized protein FPV045
V055_FOWPN Putative Ig-like V-type domain-containing protein FPV055 (Protein Y)
V061_FOWPN Putative CC-type chemokine FPV061
V130_FOWPN Protein FPV130
V204_FOWPN Uncharacterized serpin-like protein FPV204
V206_FOWPN G-protein coupled receptor homolog FPV206
V228_FOWPN Putative ankyrin repeat protein FPV228
V235_FOWPN Putative protein FPV235 (BamHI-ORF11)
V237_FOWPN Uncharacterized protein FPV237 (BamHI-ORF9)
V241_FOWPN Putative ankyrin repeat protein FPV241
V243_FOWPN Putative ankyrin repeat protein FPV243
V244_FOWPN Putative ankyrin repeat protein FPV244
V245_FOWPN Putative ankyrin repeat protein FPV245
V246_FOWPN Putative ankyrin repeat protein FPV246
V250_FOWPN Uncharacterized protein FPV250 (BamHI-ORF4)
RAP94_FOWPN RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated ...
KITH_FOWPN Thymidine kinase (EC 2.7.1.21)

3 entries

Canarypox virus (CNPV) reference strain

Select_allDeselect_all
PAP1_CNPV Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
D3_CNPV 27 kDa core protein
ARBH_CNPV Apoptosis regulator Bcl-2 homolog (vBcl-2)