Poxviridae (taxid:10240)
VIRION
Enveloped, brick-shaped or ovoid virion, 220-450 nm long and 140-260 nm wide. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).
- Major core protein [OPG 136]
GENOME
Linear, dsDNA genome of 130-375kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
GENE EXPRESSION
ENZYMES
- DNA-directed DNA polymerase B [E9L (OPG071)]
- DNA-directed RNA polymerase [E4L (OPG066)]
- Cell-type capping
- RNA TPase [D1R (OPG113)]
- GTase [D1R (OPG113)]
- N7MTase [D1R (OPG113) + D12L (OPG124)]
- 2'O methylase [J3R (OPG102)]
- Core protease (Peptidase C57) [I7 (OPG083)]
- Metalloprotease (Peptidase M44) [G1L (OPG085)]
- Phospholipase [F13 (OPG057)]
REPLICATION
CYTOPLASMIC
- Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
- Fusion with the plasma membrane to release the core into the host cytoplasm.
- Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
- Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
- Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
- Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
- Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
- IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).
Host-virus interaction
Adaptive immune response inhibition
The vaccinia virus A35R localizes to host endosomes and inhibits MHC class II antigen presentation 
. Additionally, the poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules .
Apoptosis modulation
Several poxviral proteins are dedicated to the inhibition of host apoptosis. For example Myxoma virus M11L alters the pathway by preventing the conformational activation of host Bax at the mitochondria .
Vaccinia F1L functions both as a suppressor of proapoptotic Bcl-2 family of proteins and as an inhibitor of caspase-9 .
Molluscipoxviruses encode a viral FLICE-inhibitory protein (v-FLIP) that prevents apoptosis induced by death receptors .
FPV039 inhibits apoptosis by sequestering and inactivating multiple proapoptotic Bcl-2 proteins, including Bak and Bax .
Autophagy modulation
Vaccinia virus actively disrupts the cellular autophagy through a mechanism that involves aberrant LC3 lipidation and a direct conjugation between ATG12 and ATG3 .
Cell-cycle modulation
The myxomavirus Ankyrin repeat domain-containing protein M-T5 is an adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins including CDKN1B. Disappearance of host CDKN1B correlates with cell cycle progression through the G0/G1 checkpoint .
NF-kappa-B modulation
The B14 protein from vaccinia virus functions by binding to the IKK complex via an interaction with IKK-beta and preventing the phosphorylation of IKK-beta on its activation loop. In turn, IKK-beta is not activated and fails to phosphorylate IkB-beta, leaving IkB-beta able to retain NF-kappa-B in the cytoplasm . MC159 protein from the molluscum contagiosum instead inhibits NF-kappa-B activation by interacting with the IkB kinase complex .
Innate immune response inhibition
Poxviruses inhibit the cascade leading to production of interferon-beta by mainly targeting the host IRF3 protein. For instance, vaccinia virus protein C6 inhibits IRF3 activation downstream of TBK1 .
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)1536 entries grouped by protein
6 entries
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase (3-beta-HSD)
1 entry
Truncated 3-beta hydroxy-5-ene steroid dehydrogenase homolog
1 entry
Protein A11 homolog
1 entry
Virion membrane protein A13 homolog
1 entry
Virion membrane protein A14 homolog
1 entry
Core protein A15 homolog
4 entries
Virion membrane protein A16
1 entry
Virion membrane protein A17 precursor homolog
13 entries
Transcript termination protein A18 (EC 3.6.4.-)
1 entry
Protein A19 homolog
1 entry
DNA polymerase processivity factor component A20
2 entries
Virion membrane protein A21
1 entry
Putative A-type inclusion protein (ATI) (Protein A26)
10 entries
Envelope protein A28 homolog (Protein 118)
1 entry
Protein A30 homolog
1 entry
Uncharacterized protein A30.5
1 entry
Truncated protein A35 homolog
1 entry
Protein A37 homolog
2 entries
Protein A37.5 homolog
3 entries
Protein A40
5 entries
Protein A47
5 entries
Protein A49
2 entries
Protein A52
1 entry
Truncated secreted TNF-receptor-like protein A53
1 entry
Truncated secreted TNF-receptor-like protein A53R
1 entry
Uncharacterized protein A56.5
2 entries
Guanylate kinase homolog
1 entry
Protein A6 homolog
1 entry
Protein A9 homolog
2 entries
Apoptosis regulator Bcl-2 homolog
6 entries
A-type inclusion protein A25 homolog (ATI)
1 entry
17 kDa A-type inclusion protein
2 entries
7 kDa A-type inclusion protein
1 entry
27 kDa A-type inclusion protein
1 entry
Kelch repeat protein B10
2 entries
Protein B14 homolog (Protein T3A)
4 entries
Protein B17
1 entry
Ankyrin repeat protein B19
1 entry
Uncharacterized protein B21
1 entry
Truncated ankyrin repeat protein B25
4 entries
Protein C10
1 entry
Protein C13
6 entries
Kelch repeat protein C2
2 entries
Uncharacterized protein C20L
2 entries
Truncated CrmB protein
2 entries
Protein C8
9 entries
Cell surface-binding protein OPG105 (Carbonic anhydrase homolog)
1 entry
Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)
6 entries
Soluble TNF receptor II (Cytokine response-modifying protein B)
2 entries
mRNA-decapping protein D10 (EC 3.1.3.-)
4 entries
Scaffold protein (62 kDa protein) (D13 ortholog) (N3L protein) (Rifampicin resistance protein)
1 entry
Core protein D4
10 entries
27 kDa core protein
1 entry
Primase D5 (EC 3.6.4.-)
3 entries
mRNA-decapping protein D9 (EC 3.1.3.-)
1 entry
Probable deoxycytidine kinase FPV059 (dCK) (EC 2.7.1.74)
1 entry
Probable deoxycytidine kinase FPV151 (dCK) (EC 2.7.1.74)
7 entries
DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase
9 entries
DNA polymerase (EC 2.7.7.7)
1 entry
Apoptosis regulator DPV022
8 entries
Dual specificity protein phosphatase OPG106 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)
15 entries
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
1 entry
Protein E11 homolog
1 entry
Protein E2 homolog
1 entry
Protein E3 homolog (Protein E3L homolog)
1 entry
Protein E6 homolog
13 entries
Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small subunit)
13 entries
Early transcription factor 82 kDa subunit (ETF large subunit)
1 entry
Protein F11 homolog
1 entry
Virion release protein (Protein F12 homolog)
3 entries
Envelope protein F13 homolog (43 kDa protein) (p43K)
1 entry
Protein F15
5 entries
Assembly protein G7
3 entries
Golgi anti-apoptotic protein (GAAP)
14 entries
Glutaredoxin-1
13 entries
Glutaredoxin-2
1 entry
Glutathione peroxidase (GPx) (GSHPx) (EC 1.11.1.9)
2 entries
Growth factor (Secreted epidermal growth factor-like)
2 entries
Late protein H2
4 entries
Late protein H7
9 entries
Protein OPG185 (Hemagglutinin)
1 entry
Telomere-binding protein I1 homolog (Protein FPV90)
1 entry
Protein I2 homolog (Protein FPV089)
1 entry
Protein I5 homolog
1 entry
Telomere-binding protein I6 homolog (Protein FPV084)
2 entries
Core protease I7 homolog (EC 3.4.22.-)
2 entries
Interleukin-18-binding protein (vIL-18BP)
5 entries
Interleukin-1-binding protein (Protein B15)
2 entries
Protein J1 homolog (Protein F7)
2 entries
Protein J5
1 entry
Protein K3 homolog
2 entries
Protein K5
2 entries
Protein K6
7 entries
Kelch repeat and BTB domain-containing protein 1
4 entries
Kelch repeat and BTB domain-containing protein 2
19 entries
Thymidine kinase (EC 2.7.1.21)
4 entries
Pseudokinase OPG198
13 entries
Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)
1 entry
Protein FPV129
1 entry
L5 homolog (Protein FPV132)
6 entries
E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)
1 entry
Apoptosis regulator M11L
1 entry
Protein MC005
1 entry
Protein MC007
1 entry
Protein MC014
1 entry
Protein MC132
1 entry
Chemokine-like protein MC148
1 entry
Protein MC160
1 entry
Apoptosis regulator MC163R
8 entries
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) polymerase regulatory subunit) (Poly(A) polymerase small subunit) (PAP-S) (VP39)
13 entries
mRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) (VTF large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme D1 subunit) (mRNA-capping enzyme large subunit)
9 entries
mRNA-capping enzyme regulatory subunit OPG124 (Virus termination factor small subunit) (VTF small subunit) (mRNA-capping enzyme 33 kDa subunit) (mRNA-capping enzyme D12 subunit) (mRNA-capping enzyme small subunit)
1 entry
Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)
2 entries
Putative glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase) (NMT) (Peptide N-myristoyltransferase)
12 entries
RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside triphosphate phosphohydrolase II) (NPH II) (RNA helicase I8)
16 entries
Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH I)
1 entry
Protein O1 homolog (Protein FPV091)
1 entry
Truncated p28 protein
1 entry
Zinc finger-containing protein P28b
1 entry
Major core protein 4a precursor (p4a) (Virion core protein 4a precursor)
1 entry
Major core protein 4b (Virion core protein 4b) (p4b)
28 entries
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
5 entries
Chemokine-binding protein (vCKBP) (35 kDa protein)
3 entries
Ankyrin repeat protein OPG003
2 entries
Protein OPG005
1 entry
Ankyrin repeat domain-containing protein OPG015
8 entries
Host range factor p28 (EC 2.3.2.27) (E3 ubiquitin-protein ligase p28)
3 entries
Ankyrin repeat domain-containing protein OPG023 (Host range protein 1)
2 entries
OPG024 protein
3 entries
Ankyrin repeat protein OPG025
9 entries
Interferon antagonist OPG027 (Host range protein 2)
5 entries
IFN signaling evasion protein OPG029
5 entries
Protein OPG030
4 entries
Protein C4
4 entries
Protein OPG034
4 entries
Protein OPG035 (Protein N1)
5 entries
Protein OPG036 (Protein N2)
4 entries
Inhibitor of Apoptosis OPG037 (Ankyrin repeat protein M1)
5 entries
Early protein OPG038 (Protein M2)
5 entries
Truncated interferon antagonist OPG039
5 entries
Superinfection exclusion protein (Protein K2) (Serine proteinase inhibitor 3)
3 entries
Protein K3
3 entries
Virion nicking-joining enzyme (Phospholipase-D-like protein K4)
1 entry
Monoglyceride lipase homolog
4 entries
Protein K7
7 entries
Apoptosis regulator OPG045 (Protein F1)
4 entries
Immune evasion protein OPG047 (Kelch repeat protein)
5 entries
Protein OPG049 (36 kDa major membrane protein F5)
7 entries
Protein OPG050 (Protein F6)
6 entries
Protein OPG051 (Protein F7)
5 entries
Protein OPG052 (Protein F8)
7 entries
EFC-associated protein OPG053 (Protein F9)
6 entries
Protein OPG055 (Protein F11)
7 entries
Protein OPG056 (Protein F12)
7 entries
Envelope phospholipase OPG057 (EC 3.1.1.-) (EC 3.1.4.4) (37 kDa protein) (Envelope phospholipase F13) (Envelope protein F13) (Palmitoylated EV membrane protein) (p37K)
7 entries
Protein OPG058 (Protein F14)
2 entries
Protein OPG059
6 entries
Protein OPG060
6 entries
Protein OPG061 (Protein F16)
7 entries
Phosphoprotein OPG062 (Phosphoprotein F17)
4 entries
Protein OPG064 (Protein E2)
4 entries
RNA-binding protein OPG065 (RNA-binding protein E3) (p25)
6 entries
Protein OPG067 (Protein E5)
5 entries
Protein OPG068 (Protein E6)
4 entries
Protein OPG069 (Protein E7)
5 entries
Protein OPG070 (Protein E8)
5 entries
Probable FAD-linked sulfhydryl oxidase OPG072 (EC 1.8.3.2) (Probable FAD-linked sulfhydryl oxidase E10) (EC 1.8.3.2)
5 entries
Core protein OPG073 (Protein E11)
4 entries
Protein OPG074 (Protein O1)
4 entries
Entry-fusion complex protein OPG076 (EFC protein OPG076)
9 entries
Telomere-binding protein OPG077 (Telomere-binding protein I1)
6 entries
Protein OPG078 (Protein I2)
5 entries
Protein OPG079 (Protein I3)
5 entries
Protein OPG081 (Protein I5)
5 entries
Telomere-binding protein OPG082 (Telomere-binding protein I6)
4 entries
Core protease OPG082 (EC 3.4.22.-) (Core protease I7) (EC 3.4.22.-)
12 entries
Metalloendopeptidase OPG085 (EC 3.4.24.-) (Metalloendopeptidase G1)
6 entries
Entry-fusion complex protein OPG086 (EFC protein OPG086) (Protein G3)
5 entries
Late transcription elongation factor OPG087 (Late transcription elongation factor G2) (Protein G2)
5 entries
Putative nuclease OPG089 (EC 3.1.-.-) (Putative nuclease G5)
5 entries
Protein OPG091 (Uncharacterized protein G6)
7 entries
Entry-fusion complex protein OPG094 (EFC protein OPG094) (Myristoylated protein G9)
7 entries
Entry-fusion complex associated protein OPG095 (EFC-associated protein OPG095) (Protein L1) (Virion membrane protein M25)
6 entries
Protein OPG096 (Protein L2)
5 entries
Protein OPG097 (Protein L3)
6 entries
Entry-fusion complex protein OPG094 (EFC protein OPG094) (Protein L5)
4 entries
Virion assembly protein OPG100 (Protein J1)
4 entries
Protein OPG104 (Protein J5)
4 entries
Late protein H2
4 entries
Envelope protein H3 (Ag35) (Virion envelope protein p35)
4 entries
Late transcription elongation factor OPG110 (Viral late gene transcription factor 4) (VLTF-4)
5 entries
Late protein OPG112
5 entries
Core protein D2
5 entries
Core protein OPG115 (27 kDa virion core protein)
5 entries
Uncoating factor OPG117 (EC 3.6.4.-)
4 entries
mRNA-decapping protein OPG121 (EC 3.1.3.-)
4 entries
mRNA-decapping protein OPG122 (EC 3.1.3.-)
6 entries
Scaffold protein OPG125 (62 kDa protein) (Rifampicin resistance protein)
4 entries
Protein OPG128
5 entries
Major core protein OPG129 (Virion core protein 4b) (p4b)
5 entries
39kDa core protein OPG130 (p39) (Protein A4)
5 entries
Virion morphogenesis protein OPG132
5 entries
Virion membrane protein OPG135
5 entries
Major core protein OPG136 precursor (p4a) (Virion core protein 4a precursor)
6 entries
Protein OPG137
6 entries
25 kDa core protein OPG138
5 entries
Virion membrane protein OPG139
5 entries
Virion membrane protein OPG140
4 entries
Virion membrane protein OPG141
6 entries
Core protein OPG142
4 entries
Virion membrane protein OPG143
5 entries
Virion membrane protein OPG144 precursor (23 kDa late protein)
5 entries
Transcript termination protein OPG145 (EC 3.6.4.-) (56 kDa abortive late protein)
5 entries
Protein OPG146
5 entries
Virion membrane protein OPG147
5 entries
DNA polymerase processivity factor component OPG148
3 entries
Envelop protein OPG153
4 entries
Protein OPG154
12 entries
Envelope protein OPG155
5 entries
Protein OPG157
5 entries
Protein OPG159
5 entries
DNA packaging protein OPG160
5 entries
Protein OPG161
4 entries
Protein OPG162
3 entries
Protein OPG163
4 entries
Protein OPG164
3 entries
Protein OPG165
5 entries
Protein OPG166
4 entries
Protein OPG170
5 entries
Protein A43
2 entries
Protein OPG173
4 entries
Protein OPG176
6 entries
Protein OPG181
5 entries
B1 kinase (Serine/threonine-protein kinase 1) (EC 2.7.11.1) (Vaccinia protein kinase 1)
5 entries
Ankyrin repeat protein OPG189
7 entries
Protein OPG190 (Plaque-size/host range protein)
3 entries
Protein OPG191
3 entries
Protein OPG192
3 entries
Soluble interferon gamma receptor OPG193 (B8)
3 entries
Protein OPG195
3 entries
Protein OPG197
5 entries
Protein OPG200
6 entries
Soluble interferon alpha/beta receptor OPG204 (S antigen)
2 entries
Protein OPG209
6 entries
Poxin-Schlafen (EC 3.1.-.-)
14 entries
Profilin
1 entry
Putative tyrosine-protein phosphatase AMV078 (EC 3.1.3.48)
7 entries
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94 kDa)
6 entries
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase large subunit) (Ribonucleotide reductase subunit 1) (RNR1)
9 entries
Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small subunit) (Ribonucleotide reductase subunit 2) (RNR2)
12 entries
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
15 entries
DNA-directed RNA polymerase 132 kDa polypeptide (EC 2.7.7.6)
7 entries
DNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6)
7 entries
DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6)
6 entries
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6)
7 entries
DNA-directed RNA polymerase 22 kDa subunit (EC 2.7.7.6)
5 entries
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6)
8 entries
DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6)
1 entry
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6)
7 entries
Resolvase OPG149 (EC 3.1.-.-)
4 entries
Semaphorin-like protein A39
1 entry
Semaphorin-like protein VACWR164
2 entries
Schlafen-like protein (Protein B3)
16 entries
Cu-Zn superoxide dismutase-like protein
1 entry
Spheroidin
9 entries
Serine proteinase inhibitor 1 (Serp-1) (Serpin-1)
8 entries
Serine proteinase inhibitor 2 (Serp-2) (Serpin-2)
1 entry
Putative serine proteinase inhibitor 2 homolog first part
1 entry
Putative serine proteinase inhibitor 2 homolog second part
2 entries
Spindolin (Fusolin) (p50)
1 entry
Truncated Cytokine response-modifying protein B
6 entries
DNA topoisomerase 1B (TopIB) (EC 5.6.2.1) (DNA topoisomerase I) (Late protein H6)
8 entries
Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
1 entry
Putative C-type lectin protein FPV001/FPV260
1 entry
Uncharacterized protein FPV002/FPV259
1 entry
Putative C-type lectin protein FPV003/FPV258
1 entry
Uncharacterized protein FPV006/FPV255 (BamHI-ORF1)
1 entry
Uncharacterized protein FPV007/FPV254
1 entry
Putative C-type lectin protein FPV008/FPV253 (BamHI-ORF2)
1 entry
Uncharacterized protein FPV009/FPV252 (ORF b)
1 entry
Uncharacterized serpin-like protein FPV010
1 entry
Soluble NSF attachment protein homolog FPV011
1 entry
Putative ankyrin repeat protein FPV012
1 entry
Putative ankyrin repeat protein FPV014
1 entry
Uncharacterized protein 16
1 entry
Uncharacterized protein 17
1 entry
Putative ankyrin repeat protein FPV018
1 entry
G-protein coupled receptor homolog FPV021
1 entry
Putative ankyrin repeat protein FPV022
1 entry
Putative ankyrin repeat protein FPV023
1 entry
Putative ankyrin repeat protein FPV024
1 entry
Putative ankyrin repeat protein FPV026
1 entry
G-protein coupled receptor homolog FPV027
1 entry
Putative peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29)
1 entry
Putative ankyrin repeat protein FPV031
1 entry
Soluble NSF attachment protein homolog FPV033
1 entry
Putative ankyrin repeat protein FPV034
1 entry
Uncharacterized serpin-like protein FPV040
1 entry
Uncharacterized protein FPV042
1 entry
Uncharacterized serpin-like protein FPV044
1 entry
Uncharacterized protein FPV045
1 entry
Putative Ig-like V-type domain-containing protein FPV055 (Protein Y)
1 entry
Putative CC-type chemokine FPV060
1 entry
Putative CC-type chemokine FPV061
1 entry
Protein FPV063 (FPLeft)
1 entry
Protein ORFV073
1 entry
Probable FAD-linked sulfhydryl oxidase FPV093 (EC 1.8.3.2)
1 entry
Protein FPV117
2 entries
Protein FPV127
1 entry
Protein FPV130
1 entry
Ankyrin repeat protein 14
1 entry
Putative ankyrin repeat protein FPV115
1 entry
Putative ankyrin repeat protein FPV162
1 entry
Uncharacterized protein AMV183/G2R
1 entry
Uncharacterized protein AMV185/G3L
1 entry
Protein FPV195
1 entry
Putative C-type lectin protein FPV198
1 entry
Uncharacterized serpin-like protein FPV204
1 entry
Uncharacterized protein VACWR204.5
1 entry
G-protein coupled receptor homolog FPV206
1 entry
Probable growth factor FPV211
1 entry
Probable serine/threonine-protein kinase FPV212 (EC 2.7.11.1)
1 entry
Putative ankyrin repeat protein FPV216
1 entry
Putative ankyrin repeat protein FPV218
1 entry
Putative ankyrin repeat protein FPV219
1 entry
Uncharacterized protein FPV220
1 entry
Putative ankyrin repeat protein FPV222
1 entry
Putative ankyrin repeat protein FPV223
1 entry
Putative ankyrin repeat protein FPV224
1 entry
Probable serine/threonine-protein kinase FPV226 (EC 2.7.11.1)
1 entry
Putative ankyrin repeat protein FPV227
1 entry
Putative ankyrin repeat protein FPV228
1 entry
Putative ankyrin repeat protein FPV230
1 entry
Putative ankyrin repeat protein FPV231
1 entry
Putative ankyrin repeat protein FPV232
1 entry
Putative ankyrin repeat protein FPV233
1 entry
Putative ankyrin repeat protein FPV234 (BamHI-ORF12/ORF13)
1 entry
Putative protein FPV235 (BamHI-ORF11)
1 entry
Uncharacterized protein FPV236 (BamHI-ORF10)
1 entry
Uncharacterized protein FPV237 (BamHI-ORF9)
1 entry
Uncharacterized protein FPV238 (ORF f)
1 entry
Putative C-type lectin protein FPV239 (BamHI-ORF8)
1 entry
Putative ankyrin repeat protein FPV240 (BamHI-ORF7)
1 entry
Putative ankyrin repeat protein FPV241
1 entry
Putative ankyrin repeat protein FPV242
1 entry
Putative ankyrin repeat protein FPV243
1 entry
Putative ankyrin repeat protein FPV244
1 entry
Putative ankyrin repeat protein FPV245
1 entry
Putative ankyrin repeat protein FPV246
1 entry
Uncharacterized protein FPV248 (BamHI-ORF6)
1 entry
Uncharacterized protein FPV249 (BamHI-ORF5)
1 entry
Uncharacterized protein FPV250 (BamHI-ORF4)
1 entry
Uncharacterized serpin-like protein FPV251
1 entry
Uncharacterized protein VACWR003
1 entry
Uncharacterized protein VACWR005
1 entry
Uncharacterized protein VACWR006
1 entry
Uncharacterized protein VACWR201
1 entry
Uncharacterized protein VACWR202
1 entry
Ankyrin repeat protein VACWR203
2 entries
Protein A54
1 entry
Truncated plaque-size/host range protein (Protein B5)
4 entries
Kelch repeat protein B10
4 entries
Ankyrin repeat protein B18
1 entry
Protein B20
1 entry
Putative Ig-like domain-containing protein C1
3 entries
Kelch repeat protein C2
1 entry
G-protein coupled receptor homolog C3
1 entry
Protein C4
1 entry
Uncharacterized protein C5
1 entry
Uncharacterized protein C6
1 entry
Uncharacterized protein C9
1 entry
Uncharacterized protein C10
1 entry
Uncharacterized protein C12
1 entry
Protein C13
1 entry
Protein C14
2 entries
Protein C15/B21
1 entry
Uncharacterized protein C16
2 entries
Ankyrin repeat protein C17/B23
2 entries
Ankyrin repeat protein C18/B24
1 entry
Protein C21/B27
2 entries
Complement control protein C3 (28 kDa protein) (Secretory protein 35) (Protein C3) (VCP)
1 entry
Ankyrin repeat protein D4L/I2R
2 entries
Vascular endothelial growth factor homolog
3 entries
10 kDa fusion protein
11 entries
Pro-vaccinia growth factor (Pro-VGF)
3 entries
Probable host range protein 2-1
2 entries
Probable host range protein 2-2
2 entries
Probable host range protein 2-3
6 entries
Probable host range protein 2
5 entries
Intermediate transcription factor 3 large subunit (VITF-3 45 kDa subunit)
1 entry
G-protein coupled receptor homolog K2
5 entries
Late transcription factor 1 (VLTF-1) (Trans-activator protein GK1)
7 entries
Viral late gene transcription factor 2 (VLTF-2) (Trans-activator protein A1)
7 entries
Viral late gene transcription factor 3 (VLTF-3) (Trans-activator protein A2)
2 entries
MF7 protein
1 entry
Kelch repeat protein M-T8
1 entry
Kelch repeat protein M-T9 (M9-R polypeptide)
1 entry
Immunodominant envelope protein p35 (Ag35) (Virion envelope protein p35)
6 entries
Core protein VP8 (25 kDa major core protein) (L4 core protein) (P25K)
9 entries
Serine/threonine-protein kinase 2 (EC 2.7.11.1) (Vaccinia protein kinase 2)
1 entry
G-protein coupled receptor homolog Q2/3L
1 entry
Protein T1
2 entries
Tumor necrosis factor soluble receptor (Protein T2)
1 entry
T3C protein
3 entries
T4 protein
1 entry
Ankyrin repeat protein T5
7 entries
Intermediate transcription factor 3 large subunit (VITF-3 45 kDa subunit)
6 entries
Intermediate transcription factor 3 small subunit (VITF-3 32 kDa subunit) (VITF-3 small subunit)
1 entry
Uncharacterized leucine-rich repeat-containing protein AMV014/Q3
1 entry
Uncharacterized protein 15
1 entry
Uncharacterized protein 36
1 entry
Uncharacterized 7.4 kDa protein
1 entry
Uncharacterized 7.5 kDa protein
1 entry
Uncharacterized protein AMV017/Q1
1 entry
Uncharacterized 14.1 kDa protein
1 entry
Uncharacterized 10.7 kDa protein
1 entry
Uncharacterized 14.4 kDa protein
1 entry
Uncharacterized 9.8 kDa protein
1 entry
Uncharacterized 18.2 kDa protein
1 entry
Uncharacterized 8.4 kDa protein
1 entry
Uncharacterized 9.3 kDa protein
1 entry
Uncharacterized 14.5 kDa protein
1 entry
Uncharacterized 8.2 kDa protein
1 entry
Uncharacterized 7.9 kDa protein
1 entry
Uncharacterized 7.5 kDa protein
2 entries
Uncharacterized 9.9 kDa protein
2 entries
Uncharacterized 8.6 kDa protein
1 entry
Uncharacterized 7.9 kDa protein
1 entry
Uncharacterized 9.5 kDa protein
1 entry
Uncharacterized 9.9 kDa protein
1 entry
Uncharacterized 8.6 kDa protein
1 entry
Uncharacterized 8.5 kDa protein
2 entries
Uncharacterized 7.5 kDa protein
2 entries
Uncharacterized 8.9 kDa protein
1 entry
Uncharacterized 8.8 kDa protein
2 entries
Uncharacterized 11.8 kDa protein
1 entry
Uncharacterized 7.9 kDa protein
1 entry
Uncharacterized 10.8 kDa protein
2 entries
Uncharacterized 7.8 kDa protein
2 entries
Uncharacterized 10.5 kDa protein
1 entry
Uncharacterized 8.4 kDa protein
1 entry
Uncharacterized 11.2 kDa protein
1 entry
Uncharacterized 7.4 kDa protein
1 entry
Uncharacterized 7.6 kDa protein
1 entry
Uncharacterized 8.0 kDa protein
1 entry
Uncharacterized 8.4 kDa protein
1 entry
Uncharacterized 9.2 kDa protein
1 entry
Uncharacterized 7.9 kDa protein
1 entry
Uncharacterized 7.2 kDa protein
2 entries
Uncharacterized 7.0 kDa protein
2 entries
Uncharacterized 8.6 kDa protein
2 entries
Uncharacterized 9.2 kDa protein
2 entries
Uncharacterized 8.5 kDa protein
2 entries
Uncharacterized 7.3 kDa protein
2 entries
Uncharacterized 7.9 kDa protein
2 entries
Uncharacterized 9.3 kDa protein
2 entries
Uncharacterized 7.7 kDa protein
2 entries
Uncharacterized 10.4 kDa protein
2 entries
Uncharacterized 7.2 kDa protein
1 entry
Uncharacterized 9.5 kDa protein
1 entry
Uncharacterized 7.6 kDa protein
1 entry
Uncharacterized 11.9 kDa protein
1 entry
Uncharacterized 8.0 kDa protein
1 entry
Uncharacterized 7.6 kDa protein
1 entry
Uncharacterized 7.6 kDa protein
1 entry
Uncharacterized 12.9 kDa protein
1 entry
Uncharacterized 7.1 kDa protein
1 entry
Uncharacterized 8.3 kDa protein
1 entry
Uncharacterized 11.6 kDa protein
1 entry
Uncharacterized 9.9 kDa protein
1 entry
Uncharacterized 7.8 kDa protein
1 entry
Uncharacterized 8.8 kDa protein
1 entry
Uncharacterized 14.3 kDa protein
1 entry
Uncharacterized 8.4 kDa protein
1 entry
Uncharacterized 8.1 kDa protein
1 entry
Uncharacterized 9.3 kDa protein
1 entry
Uncharacterized 9.4 kDa protein
1 entry
Uncharacterized 9.0 kDa protein
Adoxophyes honmai entomopoxvirus 'L' taxid:1293540
Alphaentomopoxvirus acuprea taxid:62099
BeAn 58058 virus taxid:67082
Choristoneura biennis entomopoxvirus taxid:10288
Cotia virus SPAn232 taxid:930275
Cowpox virus taxid:10243
Cowpox virus (strain Brighton Red) taxid:265872
Deerpox virus (strain Mule deer/United States/W-848-83/1983) taxid:305674
Horsepox virus taxid:397342
Molluscum contagiosum virus subtype 1 taxid:10280
Mythimna separata entomopoxvirus 'L' taxid:1293572
Nile crocodilepox virus (isolate Crocodylus niloticus/Zimbabwe/Ume/2001) taxid:1289473
Orf virus taxid:10258
Orf virus (strain Goat/Texas/SA00/2000) taxid:647330
Parapoxvirus red deer/HL953 taxid:1579460
Penguinpox virus taxid:648998
Pigeonpox virus taxid:10264
Pteropox virus taxid:1873698
Raccoon poxvirus taxid:10256
Salmon gill poxvirus taxid:1680908
Sheeppox virus taxid:10266
Sheeppox virus (strain InS-1) taxid:10268
| Protein | ModelArchive |
| Protein B14 homolog (Protein T3A) | ma-jd-viral-13479 |
| Protein B14 homolog (Protein T3A) | ma-jd-viral-13481 |
Sheeppox virus (strain KS-1) taxid:10269
| Protein | ModelArchive |
| Envelope protein A28 homolog (Protein HM3) | ma-jd-viral-31661 |
Sheeppox virus (strain Turkey/TU-V02127) taxid:654928
Turkeypox virus taxid:336486
Vaccinia virus taxid:10245
Vaccinia virus (strain Ankara) taxid:126794
Vaccinia virus (strain Copenhagen) taxid:10249
| Protein | ModelArchive |
| Protein OPG157 | ma-jd-viral-44671 |
| Scaffold protein OPG125 (62 kDa protein) (Rifampicin resistance protein) | ma-jd-viral-18034 |
Vaccinia virus (strain L-IVP) taxid:31531
Vaccinia virus (strain Tian Tan) taxid:10253
| Protein | ModelArchive |
| Phosphoprotein OPG062 (Phosphoprotein F17) | ma-jd-viral-63871 |