Enveloped, brick-shaped , 300x270x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).


Linear, dsDNA genome of about 154kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
_Sheeppox virus strain A_genome at
Poxvirus Bioinformatics Ressource center




  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Apoptosis modulation

Capripoxvirus SPI-2 inhibits the proteolytic activity of interleukin 1- converting enzyme (ICE) and ICE-like enzymes.

Matching UniProtKB/Swiss-Prot entries

14 entries grouped by strain (browse by keywords)

8 entries

Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

VFUS_SHEVK Putative fusion protein (Protein HM2)
VHR2_SHEVK Probable host range protein 2
VT4_SHEVK T4 protein
A28_SHEVK Envelope protein A28 homolog (Protein HM3)
J1_SHEVK Protein J1 homolog (Protein F7)
KITH_SHEVK Thymidine kinase (EC
VT3C_SHEVK T3C protein
VQ3L_SHEVK G-protein coupled receptor homolog Q2/3L

3 entries

Lumpy skin disease virus (isolate Bovine/Kenya/Neethling 2490/1958) (LSDV) (Lumpy skin disease virus (isolate NI-2490))

A28_LSDVN Envelope protein A28 homolog (Protein LSDV118)
VHR2_LSDVN Probable host range protein 2
PAP1_LSDVN Poly(A) polymerase catalytic subunit (EC (Poly(A) polymerase large subunit) (PAP-L)

2 entries

Sheeppox virus (strain InS-1) (SPPV) (Capripoxvirus (strain InS-1))

B14_SHEVN Protein B14 homolog (Protein T3A)
VT4_SHEVN T4 protein

1 entry

Lumpy skin disease virus (LSDV)

LAP_LSDV E3 ubiquitin-protein ligase LAP (EC (Leukemia associated protein) (LAP) (RING-type E3 ...