Capripoxvirus (taxid:10265)

VIRION

image

Enveloped, brick-shaped , 300x270x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of about 154kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Sheeppox virus strain Agenome at
Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Apoptosis modulation

Capripoxvirus SPI-2 inhibits the proteolytic activity of interleukin 1- converting enzyme (ICE) and ICE-like enzymes.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

14 entries grouped by strain

8 entries

Sheeppox virus (strain KS-1) (SPPV) (Capripoxvirus (strain KS-1))

Select_allDeselect_all
KITH_SHEVK Thymidine kinase (EC 2.7.1.21)
VFUS_SHEVK Putative fusion protein (Protein HM2)
A28_SHEVK Envelope protein A28 homolog (Protein HM3)
J1_SHEVK Protein J1 homolog (Protein F7)
VQ3L_SHEVK G-protein coupled receptor homolog Q2/3L
VT4_SHEVK T4 protein
VT3C_SHEVK T3C protein
VHR2_SHEVK Probable host range protein 2

3 entries

Lumpy skin disease virus (isolate Bovine/Kenya/Neethling 2490/1958) (LSDV) (Lumpy skin disease virus (isolate NI-2490))

Select_allDeselect_all
PAP1_LSDVN Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
A28_LSDVN Envelope protein A28 homolog (Protein LSDV118)
VHR2_LSDVN Probable host range protein 2

2 entries

Sheeppox virus (strain InS-1) (SPPV) (Capripoxvirus (strain InS-1))

Select_allDeselect_all
VT4_SHEVN T4 protein
B14_SHEVN Protein B14 homolog (Protein T3A)

1 entry

Lumpy skin disease virus (LSDV)

LAP_LSDV E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Sheeppox virus taxid:10266

Protein ModelArchive
25 kDa core protein OPG138 ma-jd-viral-61893
25 kDa core protein OPG138 ma-jd-viral-61893
25 kDa core protein OPG138 ma-jd-viral-61893
25 kDa core protein OPG138 ma-jd-viral-61893
39kDa core protein OPG130 ma-jd-viral-60356
62 kDa protein (Rifampicin resistance protein) ma-jd-viral-18011
A52R-like family protein ma-jd-viral-13470
A52R-like family protein ma-jd-viral-13479
A52R-like family protein ma-jd-viral-13481
Ankyrin repeat protein ma-jd-viral-26819
Ankyrin repeat protein ma-jd-viral-26241
Antiapoptotic protein ma-jd-viral-01712
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) ma-jd-viral-22612
Core protein VP8 ma-jd-viral-55843
Crescent formation protein ma-jd-viral-47139
DNA ligase (EC 6.5.1.1) ma-jd-viral-02904
DNA packaging protein OPG160 ma-jd-viral-10798
DNA polymerase processitivity factor (DNA polymerase processivity factor) ma-jd-viral-54864
DNA topoisomerase (EC 5.6.2.1) ma-jd-viral-17660
DNA-binding core protein (DNA-binding virion core protein) ma-jd-viral-02051
DNA-binding phosphoprotein (DNA-binding virion core protein) ma-jd-viral-63868
DNA-directed RNA polymerase (EC 2.7.7.6) ma-jd-viral-35654
DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6) ma-jd-viral-07228
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6) ma-jd-viral-53647
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-41189
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-41189
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-41189
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-41189
DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6) ma-jd-viral-13923
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6) ma-jd-viral-66511
DNA-directed RNA polymerase subunit (EC 2.7.7.6) ma-jd-viral-01536
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) (dUTP... ma-jd-viral-04286
E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) ma-jd-viral-16868
EEV glycoprotein ma-jd-viral-63555
EEV glycoprotein (IEV and EEV membrane glycoprotein) ma-jd-viral-16479
EEV host range protein ma-jd-viral-05884
EGF-like growth factor ma-jd-viral-24550
EIF2a-like PKR inhibitor (eIF2 alpha-like PKR inhibitor) (eIF2alpha-like PKR... ma-jd-viral-67099
ER-localized apoptosis regulator ma-jd-viral-04140
ER-localized apoptosis regulator ma-jd-viral-04142
Early transcription factor 82 kDa subunit (ETF large subunit) ma-jd-viral-40182
Early transcription protein ma-jd-viral-04844
Entry-fusion complex component ma-jd-viral-31661
Entry-fusion complex component (H2R homolog) (Viral membrane protein) ma-jd-viral-38024
Entry-fusion complex component (IMV membrane protein) ma-jd-viral-00099
Entry-fusion complex protein OPG086 ma-jd-viral-02212
Envelope protein (IMV envelope protein p35) (IMV heparin binding envelope protein) (IMV heparin binding surface protein) (Major envelope protein) (p32 antigen) (p32 envelope... ma-jd-viral-18657
Fen1-like nuclease ma-jd-viral-22460
Fusion protein (IMV surface protein) ma-jd-viral-35839
G-protein-coupled chemokine receptor (Putative G-protein coupled chemokine... ma-jd-viral-18479
Glutaredoxin-2 ma-jd-viral-24237
Holiday junction resolvase (Holliday junction endonuclease) ma-jd-viral-29034
Host range factor p28 (E3 ubiquitin-protein ligase p28) ma-jd-viral-21650
Host-range protein (Putative host range protein) ma-jd-viral-07837
Hyothetical protein ma-jd-viral-45619
IL-18 binding protein ma-jd-viral-16501
IL-1R (Putative IL-1-beta-inhibitor) (SPPV_04) ma-jd-viral-58965
IMV membrane protein ma-jd-viral-46273
IMV membrane protein ma-jd-viral-50419
IMV membrane protein ma-jd-viral-43070
IMV membrane protein ma-jd-viral-56084
IMV membrane protein (IMV protein) ma-jd-viral-51117
IMV membrane protein (IMV protein) ma-jd-viral-44668
IMV membrane protein (L1R) (Myristylated IMV envelope protein) ma-jd-viral-04086
IMV membrane protein (Phosphorylated IMV membrane) ma-jd-viral-00068
IMV membrane protein factor (IMV membrane receptor-like protein) (Nonessential hydrophobic IV and IMV membrane... ma-jd-viral-50931
Ig domain OX-2-like protein (Ig domain protein) ma-jd-viral-02254
Inactive Cu-Zn superoxide dismutase-like protein ma-jd-viral-65627
Intermediate transcription factor 3 large subunit ma-jd-viral-00035
Intermediate transcription factor 3 small subunit (VITF-3 32 kDa subunit) (VITF-3 small... ma-jd-viral-47959
Kelch ma-jd-viral-15715
Kelch-like protein ma-jd-viral-15702
Kelch-like protein (Putative kelch-like repeat protein) ma-jd-viral-15729
Late 16kDa putative membrane protein ma-jd-viral-35583
Late protein ma-jd-viral-37109
Late transcription elongation factor OPG087 ma-jd-viral-65994
Late transcription factor ma-jd-viral-43352
Late transcription factor 1 ma-jd-viral-21458
Leukocyte surface antigen CD47 (Integrin-associated protein) (Protein OPG166) ma-jd-viral-32405
MHC class II presentation inhibitor ma-jd-viral-11877
Maturation protein ma-jd-viral-33663
Membrane protein ma-jd-viral-22164
Metalloendopeptidase (EC 3.4.24.-) ma-jd-viral-04441
MutT motif protein (MutT motif, gene expression regulator) (mRNA decapping... ma-jd-viral-07884
Myristylated membrane protein (Myristylated protein) (Soluble myristylprotein) ma-jd-viral-22755
Myristylprotein ma-jd-viral-23571
NTPase ma-jd-viral-34249
Nucleoside triphosphatase I (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase... ma-jd-viral-23022
PRANC domain-containing protein ma-jd-viral-26269
Palmitylated EEV membrane protein (Palmitylated virion envelope protein) ma-jd-viral-42898
Phospholipase-D-like protein ma-jd-viral-42901
Pox_F15 superfamily protein ma-jd-viral-50605
Precursor of virion core protein 4a (p4a) ma-jd-viral-60229
Protein E6 homolog ma-jd-viral-36818
Protein OPG061 ma-jd-viral-14923
Protein OPG067 (Protein E5) ma-jd-viral-35748
Protein OPG070 ma-jd-viral-64785
Protein OPG079 ma-jd-viral-12942
Protein OPG091 ma-jd-viral-06068
Protein OPG181 ma-jd-viral-09725
Putative IL-1 receptor antagonist ma-jd-viral-00448
Putative ankyrin repeat protein ma-jd-viral-26186
Putative tyrosine kinase (Tyrosine protein kinase-like protein) ma-jd-viral-24788
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94... ma-jd-viral-63413
Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small... ma-jd-viral-05497
S-S bond formation pathway protein ma-jd-viral-04034
S-S bond formation pathway protein ma-jd-viral-57762
Secreted virulence factor (Virokine) ma-jd-viral-39310
Ser-Thr protein kinase, DNA replication (Ser/Thr kinase) (Ser/Thr protein... ma-jd-viral-24617
Serine protease inhibitor-like SPI-2 (Serpin) ma-jd-viral-02304
Serine/threonine-protein kinase (EC 2.7.11.1) ma-jd-viral-24799
Soluble interferon alpha/beta receptor OPG204 ma-jd-viral-13842
Soluble interferon-gamma receptor-like protein ma-jd-viral-00841
Sulfhydryl oxidase (EC 1.8.3.2) ma-jd-viral-34790
Telomere mismatch binding protein ma-jd-viral-63601
Thymidine kinase (EC 2.7.1.21) ma-jd-viral-10739
Transcript termination protein A18 ma-jd-viral-22792
Uncharacterized protein ma-jd-viral-04649
Uncharacterized protein ma-jd-viral-04681
Uncharacterized protein ma-jd-viral-06621
Uncharacterized protein ma-jd-viral-06639
Uncharacterized protein ma-jd-viral-31425
Uncharacterized protein ma-jd-viral-45704
Uncharacterized protein ma-jd-viral-43055
Uncharacterized protein ma-jd-viral-61377
Uracil-DNA glycosylase ma-jd-viral-07784
Viral core cysteine proteinase (Virion core cysteine proteinase) (Virion core... ma-jd-viral-06325
Viral interleukin-10 homolog ma-jd-viral-13429
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16062
Viral late gene transcription factor 3 ma-jd-viral-52659
Viral membrane formation protein ma-jd-viral-33162
Viral morphogenesis protein ma-jd-viral-39141
Virion core protein ma-jd-viral-01690
Virion core protein ma-jd-viral-03909
Virion core protein ma-jd-viral-04620
Virion core protein (Virion protein) ma-jd-viral-52259
Virion core protein 4b ma-jd-viral-62968
Virion morphogenesis protein ma-jd-viral-00556
Virion protein ma-jd-viral-34511
mRNA decapping enzyme ma-jd-viral-07989
mRNA-capping enzyme catalytic subunit (EC 2.1.1.56) (EC 2.7.7.50) (Virus termination factor large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large... ma-jd-viral-41041
protein-tyrosine-phosphatase (EC 3.1.3.48) ma-jd-viral-06255

Sheeppox virus (strain InS-1) taxid:10268

Protein ModelArchive
Protein B14 homolog (Protein T3A) ma-jd-viral-13479
Protein B14 homolog (Protein T3A) ma-jd-viral-13481

Sheeppox virus (strain KS-1) taxid:10269

Protein ModelArchive
Envelope protein A28 homolog (Protein HM3) ma-jd-viral-31661

Sheeppox virus (strain Turkey/TU-V02127) taxid:654928

Protein ModelArchive
25 kDa core protein OPG138 ma-jd-viral-61893
39kDa core protein OPG130 ma-jd-viral-60356
62 kDa protein (Rifampicin resistance protein) ma-jd-viral-18011
A19 family protein ma-jd-viral-33663
A52R-like family protein ma-jd-viral-13470
Ankyrin repeat protein ma-jd-viral-26819
Ankyrin repeat protein ma-jd-viral-25544
Ankyrin repeat protein ma-jd-viral-26241
Ankyrin-like protein ma-jd-viral-26186
Ankyrin-like protein ma-jd-viral-26269
Anti-apoptotic membrane protein ma-jd-viral-01712
Assembly protein G7 ma-jd-viral-34300
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) ma-jd-viral-22612
Core protein VP8 ma-jd-viral-55843
Crescent formation protein ma-jd-viral-47139
DNA ligase (EC 6.5.1.1) ma-jd-viral-02904
DNA packaging protein OPG160 ma-jd-viral-10798
DNA polymerase processitivity factor ma-jd-viral-54864
DNA topoisomerase (EC 5.6.2.1) ma-jd-viral-17660
DNA-binding virion core protein ma-jd-viral-02051
DNA-binding virion core protein ma-jd-viral-63868
DNA-directed RNA polymerase (EC 2.7.7.6) ma-jd-viral-35654
DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6) ma-jd-viral-07228
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6) ma-jd-viral-53647
DNA-directed RNA polymerase 30 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-41189
DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6) ma-jd-viral-13923
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6) ma-jd-viral-66511
DNA-directed RNA polymerase subunit (EC 2.7.7.6) ma-jd-viral-01536
DUF1029 domain-containing protein ma-jd-viral-50931
DUF2701 domain-containing protein ma-jd-viral-50419
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23) (dUTP... ma-jd-viral-04286
Double-strand RNA-binding protein ma-jd-viral-49138
E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) ma-jd-viral-16868
EEV Host range protein ma-jd-viral-05884
EEV glycoprotein ma-jd-viral-63555
EEV maturation protein ma-jd-viral-56878
EGF-like growth factor ma-jd-viral-24550
EIF2a-like PKR inhibitor ma-jd-viral-67099
ER-localized apoptosis regulator ma-jd-viral-04140
ER-localized apoptosis regulator ma-jd-viral-04142
Early transcription factor 70 kDa subunit (ATP-dependent helicase VETFS) ma-jd-viral-23092
Early transcription factor 82 kDa subunit (ETF large subunit) ma-jd-viral-40182
Early transcription protein ma-jd-viral-04844
Entry-fusion complex component ma-jd-viral-22164
Entry-fusion complex protein OPG086 ma-jd-viral-02212
Fen1-like nuclease ma-jd-viral-22460
G protein-coupled chemokine receptor-like protein ma-jd-viral-18479
Glutaredoxin-2 ma-jd-viral-24237
Holiday junction resolvase ma-jd-viral-29034
Host range factor p28 (E3 ubiquitin-protein ligase p28) ma-jd-viral-21650
Host range protein ma-jd-viral-07837
IEV and EEV membrane glycoprotein ma-jd-viral-16479
IL-1 receptor antagonist ma-jd-viral-00448
IL-1 receptor-like protein ma-jd-viral-58965
IL-18 binding protein ma-jd-viral-16501
IMV envelope protein p35 ma-jd-viral-18657
IMV membrane protein ma-jd-viral-00099
IMV membrane protein ma-jd-viral-46273
IMV membrane protein ma-jd-viral-51117
IMV membrane protein ma-jd-viral-44668
IMV membrane protein ma-jd-viral-43070
IMV membrane protein ma-jd-viral-56084
IMV surface protein ma-jd-viral-35839
Ig domain OX-2-like protein ma-jd-viral-02254
Interferon-gamma receptor ma-jd-viral-00841
Intermediate transcription factor 3 large subunit ma-jd-viral-00035
Intermediate transcription factor 3 small subunit (VITF-3 32 kDa subunit) (VITF-3 small... ma-jd-viral-47959
Kelch-like protein ma-jd-viral-15702
Kelch-like protein ma-jd-viral-15715
Kelch-like protein ma-jd-viral-15729
Late 16kDa membrane protein ma-jd-viral-35583
Late protein ma-jd-viral-37109
Late transcription elongation factor OPG087 ma-jd-viral-65994
Late transcription factor 1 ma-jd-viral-21458
Late transcription factor VLTF-4 ma-jd-viral-43352
Leukocyte surface antigen CD47 (Integrin-associated protein) (Protein OPG166) ma-jd-viral-32405
MHC class II presentation inhibitor ma-jd-viral-11877
Metalloendopeptidase (EC 3.4.24.-) ma-jd-viral-04441
MutT motif ma-jd-viral-07989
Myristylated IMV envelope protein ma-jd-viral-04086
Myristylated protein ma-jd-viral-22755
NTPase DNA replication ma-jd-viral-34249
NUDIX domain-containing protein ma-jd-viral-07884
Nucleoside triphosphatase I (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase... ma-jd-viral-23022
Palmytilated EEV membrane glycoprotein ma-jd-viral-42898
Phospholipase-D-like protein ma-jd-viral-42901
Phosphorylated IMV membrane protein ma-jd-viral-00068
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large... ma-jd-viral-36200
Poxvirus myristoylprotein ma-jd-viral-23571
Protein E6 homolog ma-jd-viral-36818
Protein OPG061 ma-jd-viral-14923
Protein OPG067 (Protein E5) ma-jd-viral-35748
Protein OPG070 ma-jd-viral-64785
Protein OPG079 ma-jd-viral-12942
Protein OPG091 ma-jd-viral-06068
Protein OPG161 ma-jd-viral-03060
Protein OPG181 ma-jd-viral-09725
Protein kinase ma-jd-viral-24788
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94... ma-jd-viral-63413
Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small... ma-jd-viral-05497
S-S bond formation pathway protein ma-jd-viral-04034
S-S bond formation pathway protein ma-jd-viral-57762
Ser/Thr protein kinase, DNA replication ma-jd-viral-24617
Serine/threonine-protein kinase (EC 2.7.11.1) ma-jd-viral-24799
Serpin ma-jd-viral-02304
Soluble interferon alpha/beta receptor OPG204 ma-jd-viral-13842
Sulfhydryl oxidase (EC 1.8.3.2) ma-jd-viral-34790
Superoxide dismutase precursor ma-jd-viral-65627
Telomere mismatch binding protein ma-jd-viral-63601
Thymidine kinase (EC 2.7.1.21) ma-jd-viral-10739
Transcript termination protein A18 ma-jd-viral-22792
Uncharacterized protein ma-jd-viral-04649
Uncharacterized protein ma-jd-viral-04681
Uncharacterized protein ma-jd-viral-06621
Uncharacterized protein ma-jd-viral-06639
Uncharacterized protein ma-jd-viral-31425
Uncharacterized protein ma-jd-viral-50605
Uncharacterized protein ma-jd-viral-45619
Uncharacterized protein ma-jd-viral-45704
Uncharacterized protein ma-jd-viral-43055
Uncharacterized protein ma-jd-viral-61377
Uracil DNA glycosylase ma-jd-viral-07784
Viral interleukin-10 homolog ma-jd-viral-13429
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16062
Viral late gene transcription factor 3 ma-jd-viral-52659
Viral membrane formation protein ma-jd-viral-33162
Viral membrane protein ma-jd-viral-38024
Viral morphogenesis protein ma-jd-viral-39141
Virion core protein ma-jd-viral-03909
Virion core protein ma-jd-viral-04620
Virion core protein ma-jd-viral-06325
Virion core protein 4b ma-jd-viral-62968
Virion core protein P4a ma-jd-viral-60229
Virion morphogenesis protein ma-jd-viral-00556
Virion protein ma-jd-viral-01690
Virion protein ma-jd-viral-34511
Virion protein ma-jd-viral-52259
Virokine ma-jd-viral-39310
mRNA capping enzyme, small subunit ma-jd-viral-09998
mRNA-capping enzyme catalytic subunit (EC 2.1.1.56) (EC 2.7.7.50) (Virus termination factor large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large... ma-jd-viral-41041
protein-tyrosine-phosphatase (EC 3.1.3.48) ma-jd-viral-06255