Roseolovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Occasionally, the viral genome can be integrated in host chromosome thereby creating a latent virus.
  5. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  6. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  7. A first round of circular genome amplification occurs by bidirectional replication
  8. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  9. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  10. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

The HHV-6 U24 protein downregulates the T-cell receptor complex and impairs T-cell activation.

Cell-cycle modulation

The UL24 protein homolog induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

HHV-6 protein IE1 interferes with the binding of IRF3 to the IFN-beta promoter, reduces levels of dimerized IRF3 and nucleus-translocated IRF3 in response to activation by TBK1. This inhibiton of the pathway through IRF3 subsequenty prevents the expression IFN-beta.

Host splicing inhibition

HHV-6 UL42 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

276 entries grouped by strain (browse by keywords)

All proteins are shown (view only 262 complete proteome entries)

101 entries

Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

Select_allDeselect_all
CCU83_HHV6U Putative CC-type chemokine U83
U16_HHV6U Protein U17/U16
U17_HHV6U Protein U17
U61_HHV6U Uncharacterized protein U61
U6_HHV6U Uncharacterized protein U6
UL88_HHV6U Protein U59
U79_HHV6U Protein U79/U80
U20_HHV6U Glycoprotein U20
U23_HHV6U Glycoprotein U23
UL24_HHV6U Protein UL24 homolog
U22_HHV6U Glycoprotein U22
UL96_HHV6U Protein U68
UL38_HHV6U Apoptosis inhibitor U19
VU9_HHV6U Protein U9
VU8_HHV6U Protein U8
VU7_HHV6U Protein U7
UL92_HHV6U Protein U63
VU25_HHV6U Protein U25
U1_HHV6U Uncharacterized protein U1
VU94_HHV6U Protein U94
VU84_HHV6U Protein U84
VPAP_HHV6U DNA polymerase processivity factor (Phosphoprotein P41) (PP41) (Polymerase accessory protein) (PAP)
SCP_HHV6U Small capsomere-interacting protein
TRM3_HHV6U Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
VU55_HHV6U Uncharacterized protein U55
U78_HHV6U Uncharacterized protein U78
VU1_HHV6U Protein U1
UL49_HHV6U Protein U33
U21_HHV6U Glycoprotein U21
UL91_HHV6U Protein U62
U95_HHV6U Uncharacterized protein U95
VU10_HHV6U U10 protein
SCAF_HHV6U Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
TEG7_HHV6U Tegument protein UL51 homolog
UL95_HHV6U Protein U67
TRM1_HHV6U Tripartite terminase subunit 1
TRX2_HHV6U Triplex capsid protein 2
VU3_HHV6U Protein U3
U18_HHV6U Putative immediate early glycoprotein (Protein U18)
UL33_HHV6U G-protein coupled receptor homolog U12
U91_HHV6U Uncharacterized protein U91
UL87_HHV6U Protein U58
ITP_HHV6U Inner tegument protein
PP85_HHV6U Phosphoprotein 85 (pp85) (Protein U14)
VU26_HHV6U Protein U26
P100_HHV6U Large structural phosphoprotein (100 kDa phosphoprotein) (pp100) (Major antigenic structural ...
LJ1_HHV6U Uncharacterized protein LJ1
OX2V_HHV6U Putative OX-2 membrane glycoprotein homolog (Protein U85)
TRX1_HHV6U Triplex capsid protein 1
HEPA_HHV6U DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
U15_HHV6U Uncharacterized protein U15
UNG_HHV6U Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VU5_HHV6U Protein U5
VU54_HHV6U Protein U54
VU51_HHV6U G-protein coupled receptor homolog U51
UL79_HHV6U Protein U52
U13_HHV6U Uncharacterized protein U13
U88_HHV6U Uncharacterized protein U88
VU4_HHV6U Protein U4
U24_HHV6U U24 protein
UL32_HHV6U Packaging protein UL32
OBP_HHV6U Replication origin-binding protein (OBP)
TRM2_HHV6U Tripartite terminase subunit 2
NEC2_HHV6U Nuclear egress protein 2
GH_HHV6U Envelope glycoprotein H (gH)
HELI_HHV6U DNA replication helicase (EC 3.6.4.-)
MCP_HHV6U Major capsid protein (MCP)
GN_HHV6U Envelope glycoprotein N
RJ1_HHV6U Protein RJ1 (Protein LT1)
RIR1_HHV6U Ribonucleoside-diphosphate reductase large subunit-like protein
ICP27_HHV6U mRNA export factor ICP27 homolog
PRIM_HHV6U DNA primase (EC 2.7.7.-)
GQ2_HHV6U Glycoprotein Q2 (gQ2) (Glycoprotein Q-37k) (gQ-37k)
DPOL_HHV6U DNA polymerase catalytic subunit (EC 2.7.7.7)
IE1_HHV6U Immediate-early protein 1 (IE1) (Protein RF2/RF3/RF4) (pRF2/pRF3/pRF4)
DR3_HHV6U Uncharacterized protein DR3
PORTL_HHV6U Portal protein
NEC1_HHV6U Nuclear egress protein 1
GM_HHV6U Envelope glycoprotein M (gM)
GCVK_HHV6U Probable ganciclovir kinase (EC 2.7.1.-)
CEP3_HHV6U Cytoplasmic envelopment protein 3
CVC2_HHV6U Capsid vertex component 2
IE2_HHV6U Immediate-early protein 2 (IE2)
DR1_HHV6U Uncharacterized protein DR1
DR6_HHV6U Uncharacterized protein DR6
GO_HHV6U 120 kDa Glycoprotein O (gO-120K) (Glycoprotein U47) [Cleaved into: 80 kDa Glycoprotein O (gO-80K)]
GB_HHV6U Envelope glycoprotein B (gB)
DR7_HHV6U Uncharacterized protein DR7
CEP1_HHV6U Cytoplasmic envelopment protein 1
AN_HHV6U Alkaline nuclease (EC 3.1.-.-)
LTP_HHV6U Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
CEP2_HHV6U Cytoplasmic envelopment protein 2
DR8_HHV6U Uncharacterized protein DR8
DR2_HHV6U Uncharacterized protein DR2
DR4_HHV6U Uncharacterized protein DR4
DNBI_HHV6U Major DNA-binding protein
DUT_HHV6U Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CVC1_HHV6U Capsid vertex component 1
DR5_HHV6U Uncharacterized protein DR5
GL_HHV6U Envelope glycoprotein L (gL)
GQ1_HHV6U Glycoprotein Q1 (gQ1) (Glycoprotein 105) (gp105) (Glycoprotein Q-80k) (gQ-80k) (HCLF1 protein)

98 entries

Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Select_allDeselect_all
B4_HHV6Z Protein B4
CEP1_HHV6Z Cytoplasmic envelopment protein 1
CCU83_HHV6Z Putative CC-type chemokine U83
U21_HHV6Z U21 glycoprotein
U6_HHV6Z Uncharacterized protein U6
VU2_HHV6Z Protein U2
U17_HHV6Z Protein U17
VU25_HHV6Z Protein U25
VU3_HHV6Z Protein U3
VU4_HHV6Z Protein U4
UL95_HHV6Z Protein U67
UL49_HHV6Z Protein U33
UL87_HHV6Z Protein U58
U23_HHV6Z Protein U23
U20_HHV6Z Glycoprotein U20
UL96_HHV6Z Protein U68
VPAP_HHV6Z DNA polymerase processivity factor (Phosphoprotein P41) (PP41) (Polymerase accessory protein) (PAP)
VU84_HHV6Z Protein U84
U79_HHV6Z Protein U79
VU7_HHV6Z Protein U7
VU8_HHV6Z Protein U8
U22_HHV6Z Protein U22
UL38_HHV6Z Apoptosis inhibitor U19
U15_HHV6Z Protein U15
U24_HHV6Z U24 protein
U90_HHV6Z Protein U90
VU26_HHV6Z Protein U26
UL79_HHV6Z Protein U52
VU54_HHV6Z Protein U54
SCAF_HHV6Z Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
U18_HHV6Z Putative immediate early glycoprotein (Protein U18)
VU51_HHV6Z G-protein coupled receptor homolog U51
UL32_HHV6Z Packaging protein UL32 homolog
U13_HHV6Z Uncharacterized protein U13
VGCR_HHV6Z G-protein coupled receptor
VU94_HHV6Z Protein U94
VU9_HHV6Z Protein U9
VU55_HHV6Z Uncharacterized protein U55
U91_HHV6Z Protein U91
U24A_HHV6Z Uncharacterized protein U24A
UL88_HHV6Z Protein U59
UL92_HHV6Z Protein U63
UL24_HHV6Z Protein UL24 homolog
SCP_HHV6Z Small capsomere-interacting protein
TRM1_HHV6Z Tripartite terminase subunit 1
OX2V_HHV6Z Putative OX-2 membrane glycoprotein homolog (Protein U85)
TRX2_HHV6Z Triplex capsid protein 2
UNG_HHV6Z Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
U10_HHV6Z Protein U10
TEG7_HHV6Z Tegument protein UL51 homolog
TRM2_HHV6Z Tripartite terminase subunit 2
UL91_HHV6Z Protein U62
U95_HHV6Z Uncharacterized protein U95
P100_HHV6Z Large structural phosphoprotein (100 kDa phosphoprotein) (pp100) (Major antigenic structural ...
RIR1_HHV6Z Ribonucleoside-diphosphate reductase large subunit-like protein
TRM3_HHV6Z Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX1_HHV6Z Triplex capsid protein 1
NEC2_HHV6Z Nuclear egress protein 2
MCP_HHV6Z Major capsid protein (MCP)
NEC1_HHV6Z Nuclear egress protein 1
HEPA_HHV6Z DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
HELI_HHV6Z DNA replication helicase (EC 3.6.4.-)
DR3_HHV6Z Uncharacterized protein DR3
OBP_HHV6Z Replication origin-binding protein (OBP)
ICP27_HHV6Z mRNA export factor ICP27 homolog
ITP_HHV6Z Inner tegument protein
CEP3_HHV6Z Cytoplasmic envelopment protein 3
CVC1_HHV6Z Capsid vertex component 1
IE2_HHV6Z Immediate-early protein 2 (IE2)
PORTL_HHV6Z Portal protein
DPOL_HHV6Z DNA polymerase catalytic subunit (EC 2.7.7.7)
PRIM_HHV6Z DNA primase (EC 2.7.7.-)
GQ2_HHV6Z Glycoprotein Q2 (gQ2)
LTP_HHV6Z Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
PP85_HHV6Z Phosphoprotein 85 (pp85) (Protein U14)
GM_HHV6Z Envelope glycoprotein M (gM)
B2_HHV6Z Protein B2
DUT_HHV6Z Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CVC2_HHV6Z Capsid vertex component 2
B6_HHV6Z Protein B6
AN_HHV6Z Alkaline nuclease (EC 3.1.-.-)
B7_HHV6Z Protein B7
B3_HHV6Z Protein B3
GB_HHV6Z Envelope glycoprotein B (gB)
DR6_HHV6Z Uncharacterized protein DR6
DNBI_HHV6Z Major DNA-binding protein
GH_HHV6Z Envelope glycoprotein H (gH)
GL_HHV6Z Envelope glycoprotein L (gL)
DR1_HHV6Z Uncharacterized protein DR1
CEP2_HHV6Z Cytoplasmic envelopment protein 2
B1_HHV6Z Protein B1
B5_HHV6Z Protein B5
B9_HHV6Z Protein B9
GO_HHV6Z 130 kDa Glycoprotein O (gO-130K) (Glycoprotein U47) [Cleaved into: 80 kDa Glycoprotein O (gO-80K)]
GCVK_HHV6Z Probable ganciclovir kinase (EC 2.7.1.-)
B8_HHV6Z Protein B8
GQ1_HHV6Z Glycoprotein Q1 (gQ1) (Glycoprotein 105) (gp105) (Glycoprotein Q-80k) (gQ-80k) (HCLF1 protein)
GN_HHV6Z Envelope glycoprotein N

63 entries

Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)

Select_allDeselect_all
TRX1_HHV7J Triplex capsid protein 1
UL88_HHV7J Protein U59
UL92_HHV7J Protein U63
U21_HHV7J U21 glycoprotein
UL95_HHV7J Protein U67
V55B_HHV7J Uncharacterized protein U55B
UNG_HHV7J Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL32_HHV7J Packaging protein UL32
VU8_HHV7J Protein U8
VU54_HHV7J Protein U54
UL49_HHV7J Protein U33
U24_HHV7J U24 protein
VU3_HHV7J Protein U3
UL87_HHV7J Protein U58
TRX2_HHV7J Triplex capsid protein 2
VU5_HHV7J Protein U5
VU26_HHV7J Protein U26
SCAF_HHV7J Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
ITP_HHV7J Inner tegument protein
UL33_HHV7J G-protein coupled receptor homolog U12
UL91_HHV7J Protein U62
VU25_HHV7J Protein U25
VU51_HHV7J G-protein coupled receptor homolog U51
U79_HHV7J Protein U79
V55A_HHV7J Uncharacterized protein U55A
VPAP_HHV7J DNA polymerase processivity factor (Polymerase accessory protein) (PAP)
TEG7_HHV7J Tegument protein UL51 homolog
PORTL_HHV7J Portal protein
ICP27_HHV7J mRNA export factor ICP27 homolog
VU10_HHV7J U10 protein
VU4_HHV7J Protein U4
UL96_HHV7J Protein U68
VU84_HHV7J Protein U84
UL79_HHV7J Protein U52
TRM1_HHV7J Tripartite terminase subunit 1
UL24_HHV7J Protein UL24 homolog
OBP_HHV7J Replication origin-binding protein (OBP)
TRM3_HHV7J Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
GB_HHV7J Envelope glycoprotein B (gB)
NEC2_HHV7J Nuclear egress protein 2
HEPA_HHV7J DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
GM_HHV7J Envelope glycoprotein M (gM)
HELI_HHV7J DNA replication helicase (EC 3.6.4.-)
RIR1_HHV7J Ribonucleoside-diphosphate reductase large subunit-like protein
P100_HHV7J Large structural phosphoprotein (100 kDa phosphoprotein) (pp100)
NEC1_HHV7J Nuclear egress protein 1
PRIM_HHV7J DNA primase (EC 2.7.7.-)
MCP_HHV7J Major capsid protein (MCP)
DUT_HHV7J Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GL_HHV7J Envelope glycoprotein L (gL)
CEP1_HHV7J Cytoplasmic envelopment protein 1
CEP3_HHV7J Cytoplasmic envelopment protein 3
LTP_HHV7J Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
DNBI_HHV7J Major DNA-binding protein
AN_HHV7J Alkaline nuclease (EC 3.1.-.-)
CEP2_HHV7J Cytoplasmic envelopment protein 2
CVC2_HHV7J Capsid vertex component 2
GCVK_HHV7J Probable ganciclovir kinase (EC 2.7.1.-)
CVC1_HHV7J Capsid vertex component 1
GH_HHV7J Envelope glycoprotein H (gH)
DPOL_HHV7J DNA polymerase catalytic subunit (EC 2.7.7.7)
GO_HHV7J Glycoprotein U47 homolog
GN_HHV7J Envelope glycoprotein N

11 entries

Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

Select_allDeselect_all
UL24_HHV6G Protein UL24 homolog
VU26_HHV6G Protein U26
U16_HHV6G Protein U17/U16
U17_HHV6G Protein U17
LTP_HHV6G Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
DUT_HHV6G Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
IE2_HHV6G Immediate-early protein 2 (IE2)
GP105_HHV6G Glycoprotein 105 (gp105)
GB_HHV6G Envelope glycoprotein B (gB)
GH_HHV6G Envelope glycoprotein H (gH)
GO_HHV6G 120 kDa Glycoprotein O (gO-120K) (Glycoprotein U47) [Cleaved into: 80 kDa Glycoprotein O (gO-80K)]

1 entry

Human herpesvirus 6B (HHV-6 variant B) (Human B lymphotropic virus)

U79_HHV6H Protein U79/U80

1 entry

Human herpesvirus 7 (strain MUK) (HHV-7) (Human T lymphotropic virus)

TRX2_HHV7M Triplex capsid protein 2

1 entry

Human herpesvirus 7 (strain RK) (HHV-7) (Human T lymphotropic virus)

U21_HHV7R U21 glycoprotein (gp60)