Roseolovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Occasionally, the viral genome can be integrated in host chromosome thereby creating a latent virus.
  5. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  6. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  7. A first round of circular genome amplification occurs by bidirectional replication
  8. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  9. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  10. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

The HHV-6 U24 protein downregulates the T-cell receptor complex and impairs T-cell activation.

Cell-cycle modulation

The UL24 protein homolog induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

HHV-6 protein IE1 interferes with the binding of IRF3 to the IFN-beta promoter, reduces levels of dimerized IRF3 and nucleus-translocated IRF3 in response to activation by TBK1. This inhibiton of the pathway through IRF3 subsequenty prevents the expression IFN-beta.

Host splicing inhibition

HHV-6 UL42 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

275 entries grouped by strain (browse by keywords)

All proteins are shown (view only 261 complete proteome entries)

101 entries

Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

Select_allDeselect_all
CCU83_HHV6U Putative CC-type chemokine U83
AN_HHV6U Alkaline nuclease (EC 3.1.-.-)
U6_HHV6U Uncharacterized protein U6
VU9_HHV6U Protein U9
VU51_HHV6U G-protein coupled receptor homolog U51
VU54_HHV6U Protein U54
U16_HHV6U Protein U17/U16
UL33_HHV6U G-protein coupled receptor homolog U12
DPOL_HHV6U DNA polymerase catalytic subunit (EC 2.7.7.7)
GQ2_HHV6U Glycoprotein Q2 (gQ2) (Glycoprotein Q-37k) (gQ-37k)
CEP2_HHV6U Cytoplasmic envelopment protein 2
DR7_HHV6U Uncharacterized protein DR7
CEP1_HHV6U Cytoplasmic envelopment protein 1
ICP27_HHV6U mRNA export factor ICP27 homolog
CEP3_HHV6U Cytoplasmic envelopment protein 3
GO_HHV6U 120 kDa Glycoprotein O (gO-120K) (Glycoprotein U47) [Cleaved into: 80 kDa Glycoprotein O (gO-80K)]
SCAF_HHV6U Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
PP85_HHV6U Phosphoprotein 85 (pp85) (Protein U14)
VU1_HHV6U Protein U1
U17_HHV6U Protein U17
VU8_HHV6U Protein U8
UL49_HHV6U Protein U33
U88_HHV6U Uncharacterized protein U88
U20_HHV6U Glycoprotein U20
DR4_HHV6U Uncharacterized protein DR4
GL_HHV6U Envelope glycoprotein L (gL)
DUT_HHV6U Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
DNBI_HHV6U Major DNA-binding protein
IE1_HHV6U Immediate-early protein 1 (IE1) (Protein RF2/RF3/RF4) (pRF2/pRF3/pRF4)
GN_HHV6U Envelope glycoprotein N
DR5_HHV6U Uncharacterized protein DR5
GH_HHV6U Envelope glycoprotein H (gH)
CVC1_HHV6U Capsid vertex component 1
ITP_HHV6U Inner tegument protein
PRIM_HHV6U DNA primase (EC 2.7.7.-)
LTP_HHV6U Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
DR1_HHV6U Uncharacterized protein DR1
DR3_HHV6U Uncharacterized protein DR3
GM_HHV6U Envelope glycoprotein M (gM)
GCVK_HHV6U Probable ganciclovir kinase (EC 2.7.1.-)
GB_HHV6U Envelope glycoprotein B (gB)
DR8_HHV6U Uncharacterized protein DR8
OBP_HHV6U Replication origin-binding protein (OBP)
NEC1_HHV6U Nuclear egress protein 1
HEPA_HHV6U DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
HELI_HHV6U DNA replication helicase (EC 3.6.4.-)
P100_HHV6U Large structural phosphoprotein (100 kDa phosphoprotein) (pp100) (Major antigenic structural ...
CVC2_HHV6U Capsid vertex component 2
LJ1_HHV6U Uncharacterized protein LJ1
IE2_HHV6U Immediate-early protein 2 (IE2)
RIR1_HHV6U Ribonucleoside-diphosphate reductase large subunit-like protein
MCP_HHV6U Major capsid protein (MCP)
TRX2_HHV6U Triplex capsid protein 2
U18_HHV6U Putative immediate early glycoprotein (Protein U18)
U24_HHV6U Glycoprotein U24
U15_HHV6U Uncharacterized protein U15
UL87_HHV6U Protein U58
VU84_HHV6U Protein U84
TRX1_HHV6U Triplex capsid protein 1
VU5_HHV6U Protein U5
PORTL_HHV6U Portal protein
SCP_HHV6U Small capsomere-interacting protein
TRM1_HHV6U Tripartite terminase subunit 1
NEC2_HHV6U Nuclear egress protein 2
RJ1_HHV6U Protein RJ1 (Protein LT1)
VU26_HHV6U Protein U26
VU3_HHV6U Protein U3
TRM2_HHV6U Tripartite terminase subunit 2
OX2V_HHV6U Putative OX-2 membrane glycoprotein homolog (Protein U85)
UL38_HHV6U Apoptosis inhibitor U19
U95_HHV6U Uncharacterized protein U95
U78_HHV6U Uncharacterized protein U78
TRM3_HHV6U Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
VU10_HHV6U U10 protein
VU25_HHV6U Protein U25
UL96_HHV6U Protein U68
UL95_HHV6U Protein U67
U21_HHV6U Glycoprotein U21
U23_HHV6U Glycoprotein U23
U13_HHV6U Uncharacterized protein U13
U61_HHV6U Uncharacterized protein U61
VU7_HHV6U Protein U7
UL32_HHV6U Packaging protein UL32
VU55_HHV6U Uncharacterized protein U55
UNG_HHV6U Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
VU94_HHV6U Protein U94
UL79_HHV6U Protein U52
U91_HHV6U Uncharacterized protein U91
U22_HHV6U Glycoprotein U22
TEG7_HHV6U Tegument protein UL51 homolog
VU4_HHV6U Protein U4
UL24_HHV6U Protein UL24 homolog
UL88_HHV6U Protein U59
UL91_HHV6U Protein U62
U1_HHV6U Uncharacterized protein U1
U79_HHV6U Protein U79/U80
VPAP_HHV6U DNA polymerase processivity factor (Phosphoprotein P41) (PP41) (Polymerase accessory protein) (PAP)
UL92_HHV6U Protein U63
GQ1_HHV6U Glycoprotein Q1 (gQ1) (Glycoprotein 105) (gp105) (Glycoprotein Q-80k) (gQ-80k) (HCLF1 protein)
DR2_HHV6U Uncharacterized protein DR2
DR6_HHV6U Uncharacterized protein DR6

98 entries

Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Select_allDeselect_all
B5_HHV6Z Protein B5
B9_HHV6Z Protein B9
CEP1_HHV6Z Cytoplasmic envelopment protein 1
AN_HHV6Z Alkaline nuclease (EC 3.1.-.-)
DR1_HHV6Z Uncharacterized protein DR1
UL96_HHV6Z Protein U68
VU54_HHV6Z Protein U54
U90_HHV6Z Protein U90
U18_HHV6Z Putative immediate early glycoprotein (Protein U18)
U10_HHV6Z Protein U10
U20_HHV6Z Glycoprotein U20
DPOL_HHV6Z DNA polymerase catalytic subunit (EC 2.7.7.7)
GQ2_HHV6Z Glycoprotein Q2 (gQ2)
ICP27_HHV6Z mRNA export factor ICP27 homolog
DNBI_HHV6Z Major DNA-binding protein
VU55_HHV6Z Uncharacterized protein U55
VU8_HHV6Z Protein U8
U13_HHV6Z Uncharacterized protein U13
CVC1_HHV6Z Capsid vertex component 1
CCU83_HHV6Z Putative CC-type chemokine U83
B1_HHV6Z Protein B1
CVC2_HHV6Z Capsid vertex component 2
GO_HHV6Z 130 kDa Glycoprotein O (gO-130K) (Glycoprotein U47) [Cleaved into: 80 kDa Glycoprotein O (gO-80K)]
GH_HHV6Z Envelope glycoprotein H (gH)
CEP2_HHV6Z Cytoplasmic envelopment protein 2
CEP3_HHV6Z Cytoplasmic envelopment protein 3
MCP_HHV6Z Major capsid protein (MCP)
GL_HHV6Z Envelope glycoprotein L (gL)
DUT_HHV6Z Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
P100_HHV6Z Large structural phosphoprotein (100 kDa phosphoprotein) (pp100) (Major antigenic structural ...
B3_HHV6Z Protein B3
B7_HHV6Z Protein B7
GCVK_HHV6Z Probable ganciclovir kinase (EC 2.7.1.-)
B8_HHV6Z Protein B8
DR6_HHV6Z Uncharacterized protein DR6
LTP_HHV6Z Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
OBP_HHV6Z Replication origin-binding protein (OBP)
PORTL_HHV6Z Portal protein
RIR1_HHV6Z Ribonucleoside-diphosphate reductase large subunit-like protein
ITP_HHV6Z Inner tegument protein
PRIM_HHV6Z DNA primase (EC 2.7.7.-)
NEC1_HHV6Z Nuclear egress protein 1
HEPA_HHV6Z DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
NEC2_HHV6Z Nuclear egress protein 2
OX2V_HHV6Z Putative OX-2 membrane glycoprotein homolog (Protein U85)
PP85_HHV6Z Phosphoprotein 85 (pp85) (Protein U14)
SCAF_HHV6Z Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
IE2_HHV6Z Immediate-early protein 2 (IE2)
UL92_HHV6Z Protein U63
UL49_HHV6Z Protein U33
U95_HHV6Z Uncharacterized protein U95
VU84_HHV6Z Protein U84
U21_HHV6Z U21 glycoprotein
VU25_HHV6Z Protein U25
U17_HHV6Z Protein U17
UL91_HHV6Z Protein U62
TRM2_HHV6Z Tripartite terminase subunit 2
TRM1_HHV6Z Tripartite terminase subunit 1
TRX2_HHV6Z Triplex capsid protein 2
HELI_HHV6Z DNA replication helicase (EC 3.6.4.-)
TRM3_HHV6Z Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
UL95_HHV6Z Protein U67
U6_HHV6Z Uncharacterized protein U6
U23_HHV6Z Protein U23
UL24_HHV6Z Protein UL24 homolog
VU7_HHV6Z Protein U7
VU51_HHV6Z G-protein coupled receptor homolog U51
VU94_HHV6Z Protein U94
VU9_HHV6Z Protein U9
VU3_HHV6Z Protein U3
SCP_HHV6Z Small capsomere-interacting protein
TEG7_HHV6Z Tegument protein UL51 homolog
U79_HHV6Z Protein U79
UL38_HHV6Z Apoptosis inhibitor U19
U22_HHV6Z Protein U22
UL79_HHV6Z Protein U52
VGCR_HHV6Z G-protein coupled receptor
UNG_HHV6Z Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL32_HHV6Z Packaging protein UL32 homolog
VU26_HHV6Z Protein U26
VU4_HHV6Z Protein U4
UL87_HHV6Z Protein U58
VU2_HHV6Z Protein U2
U91_HHV6Z Protein U91
U24_HHV6Z Protein U24
UL88_HHV6Z Protein U59
U15_HHV6Z Protein U15
U24A_HHV6Z Uncharacterized protein U24A
VPAP_HHV6Z DNA polymerase processivity factor (Phosphoprotein P41) (PP41) (Polymerase accessory protein) (PAP)
TRX1_HHV6Z Triplex capsid protein 1
GQ1_HHV6Z Glycoprotein Q1 (gQ1) (Glycoprotein 105) (gp105) (Glycoprotein Q-80k) (gQ-80k) (HCLF1 protein)
DR3_HHV6Z Uncharacterized protein DR3
GB_HHV6Z Envelope glycoprotein B (gB)
B2_HHV6Z Protein B2
GN_HHV6Z Envelope glycoprotein N
B4_HHV6Z Protein B4
GM_HHV6Z Envelope glycoprotein M (gM)
B6_HHV6Z Protein B6

62 entries

Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

Select_allDeselect_all
DPOL_HHV7J DNA polymerase catalytic subunit (EC 2.7.7.7)
U79_HHV7J Protein U79
VU26_HHV7J Protein U26
VU54_HHV7J Protein U54
VU84_HHV7J Protein U84
UL33_HHV7J G-protein coupled receptor homolog U12
HEPA_HHV7J DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
MCP_HHV7J Major capsid protein (MCP)
DNBI_HHV7J Major DNA-binding protein
TRM1_HHV7J Tripartite terminase subunit 1
VU25_HHV7J Protein U25
VU8_HHV7J Protein U8
VU4_HHV7J Protein U4
U21_HHV7J U21 glycoprotein
GO_HHV7J Glycoprotein U47 homolog
GM_HHV7J Envelope glycoprotein M (gM)
AN_HHV7J Alkaline nuclease (EC 3.1.-.-)
HELI_HHV7J DNA replication helicase (EC 3.6.4.-)
CEP3_HHV7J Cytoplasmic envelopment protein 3
GN_HHV7J Envelope glycoprotein N
GB_HHV7J Envelope glycoprotein B (gB)
CEP2_HHV7J Cytoplasmic envelopment protein 2
GCVK_HHV7J Probable ganciclovir kinase (EC 2.7.1.-)
ITP_HHV7J Inner tegument protein
GH_HHV7J Envelope glycoprotein H (gH)
CEP1_HHV7J Cytoplasmic envelopment protein 1
DUT_HHV7J Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
GL_HHV7J Envelope glycoprotein L (gL)
CVC1_HHV7J Capsid vertex component 1
CVC2_HHV7J Capsid vertex component 2
PRIM_HHV7J DNA primase (EC 2.7.7.-)
PORTL_HHV7J Portal protein
ICP27_HHV7J mRNA export factor ICP27 homolog
P100_HHV7J Large structural phosphoprotein (100 kDa phosphoprotein) (pp100)
NEC1_HHV7J Nuclear egress protein 1
LTP_HHV7J Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
UL24_HHV7J Protein UL24 homolog
VU51_HHV7J G-protein coupled receptor homolog U51
TEG7_HHV7J Tegument protein UL51 homolog
RIR1_HHV7J Ribonucleoside-diphosphate reductase large subunit-like protein
VU10_HHV7J U10 protein
TRX2_HHV7J Triplex capsid protein 2
VU3_HHV7J Protein U3
UL79_HHV7J Protein U52
TRM3_HHV7J Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
OBP_HHV7J Replication origin-binding protein (OBP)
VPAP_HHV7J DNA polymerase processivity factor (Polymerase accessory protein) (PAP)
V55A_HHV7J Uncharacterized protein U55A
NEC2_HHV7J Nuclear egress protein 2
TRX1_HHV7J Triplex capsid protein 1
UNG_HHV7J Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL96_HHV7J Protein U68
UL88_HHV7J Protein U59
UL95_HHV7J Protein U67
UL32_HHV7J Packaging protein UL32
UL49_HHV7J Protein U33
SCAF_HHV7J Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
VU5_HHV7J Protein U5
UL87_HHV7J Protein U58
UL92_HHV7J Protein U63
UL91_HHV7J Protein U62
V55B_HHV7J Uncharacterized protein U55B

11 entries

Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

Select_allDeselect_all
VU26_HHV6G Protein U26
U16_HHV6G Protein U17/U16
LTP_HHV6G Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
GP105_HHV6G Glycoprotein 105 (gp105)
GH_HHV6G Envelope glycoprotein H (gH)
GO_HHV6G 120 kDa Glycoprotein O (gO-120K) (Glycoprotein U47) [Cleaved into: 80 kDa Glycoprotein O (gO-80K)]
IE2_HHV6G Immediate-early protein 2 (IE2)
GB_HHV6G Envelope glycoprotein B (gB)
UL24_HHV6G Protein UL24 homolog
U17_HHV6G Protein U17
DUT_HHV6G Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

1 entry

Human herpesvirus 6B (HHV-6 variant B) (Human B lymphotropic virus)

U79_HHV6H Protein U79/U80

1 entry

Human herpesvirus 7 (strain MUK) (HHV-7) (Human T lymphotropic virus)

TRX2_HHV7M Triplex capsid protein 2

1 entry

Human herpesvirus 7 (strain RK) (HHV-7) (Human T lymphotropic virus)

U21_HHV7R U21 glycoprotein (gp60)