DNA strand displacement replication

Related to: Adenoviridae, Asfarviridae, Iridoviridae, Mimiviridae(?), Phycodnaviridae(?), Poxviridae, Tectiviridae, Phi29likevirus.

Location: In host cell nucleus (Adenoviridae) or cytoplasm (Nucleo-Cytoplasmic Large DNA viruses).

Replication events:

During strand displacement replication, only one strand is replicated at a time. This synthesis releases a single-stranded DNA, which in turn is copied into a double-stranded DNA. Replication of Adenoviridae is initiated by a pre-terminal protein (pTP), replication of Nucleo-cytoplasmic Large DNA viruses is initiated by a repeated loop at the genomic ends and produces concatemers that are processed after replication.


Function Adenoviridae Poxviridae Asfarviridae Iridoviridae
Initiation Terminal Protein Endonuclease Endonuclease Endonuclease
Topoisomerase Pol D5 ? ?
Polymerase Pol E9 ? ?
Processivity factor - A20-D4 ? ?
ssDNA binding ssDBP I3 ? ?