DNA strand displacement replication

Related to: Adenoviridae, Asfarviridae, Iridoviridae, Mimiviridae(?), Phycodnaviridae(?), Poxviridae, Tectiviridae, Phi29likevirus.

Location: In host cell nucleus (Adenoviridae) or cytoplasm (Nucleo-Cytoplasmic Large DNA viruses).

Replication events: In strand-displacement replication, only one strand is replicated at once. This synthesis releases a single stranded DNA, which is in turn copied into double strand-DNA. Adenoviridae replication is primed by a pre-Terminal Protein (pTP), Nucleo-cytoplasmic Large DNA viruses replication is primed by a repeated loop at genomic extremities and produces concatemers that are processed post-replication.


Function Adenoviridae Poxviridae Asfarviridae Iridoviridae
Initiation Terminal Protein Endonuclease Endonuclease Endonuclease
Topoisomerase Pol D5 ? ?
Polymerase Pol E9 ? ?
Processivity factor - A20-D4 ? ?
ssDNA binding ssDBP I3 ? ?