Sapovirus (taxid:95341)

VIRION

image

Non-enveloped, capsid of about 27-40 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 capsid proteins.
image

GENOME

image

Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5'-terminus is linked to a VPg protein and the 3'-terminus has a poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the mature nonstructural proteins and the capsid protein. ORF2 encodes a small structural protein VP2 which is expressed through RNA termination-reinitiation.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

10 entries grouped by protein

4 entries

Genome polyprotein

Select_allDeselect_all
POLG_SVSAP
Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain
POLG_PESV
Porcine enteric sapovirus (isolate Swine/United States/Cowden/1980) (Sw/SV/Cowden/1980/US)
POLG_SVM10
Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)
POLG_SVM93
Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)

4 entries

Minor capsid protein VP2

Select_allDeselect_all
VP2_SVSAP
Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain
VP2_PESV
Porcine enteric sapovirus (isolate Swine/United States/Cowden/1980) (Sw/SV/Cowden/1980/US)
VP2_SVM10
Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)
VP2_SVM93
Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)

2 entries

Uncharacterized protein VP3

Select_allDeselect_all
VP3_SVSAP
Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain
VP3_SVM93
Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Bat sapovirus TLC58/HK taxid:1185359

Protein ModelArchive
VP2 ma-jd-viral-58991

Sapovirus (strain GII/Human/Japan/Sakai C12/2001) taxid:290314

Protein ModelArchive
ORF2 protein ma-jd-viral-40101