Sapovirus (taxid:95341)



Non-enveloped, capsid of about 27-40 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 capsid proteins.



Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5'-terminus is linked to a VPg protein and the 3'-terminus has a poly(A) tract.


The virion RNA is infectious and serves as both the genome and viral messenger RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the mature nonstructural proteins and the capsid protein. ORF2 encodes a small structural protein VP2 which is expressed through RNA termination-reinitiation.




  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Matching UniProtKB/Swiss-Prot entries

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10 entries grouped by strain

3 entries

Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain

POLG_SVSAP Genome polyprotein [Cleaved into: NS1 (Protein p11); NS2 (Protein p28); NTPase (EC (NS3) ...
VP2_SVSAP Minor capsid protein VP2
VP3_SVSAP Uncharacterized protein VP3

3 entries

Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)

POLG_SVM93 Genome polyprotein [Cleaved into: NS1 (Protein p11); NS2 (Protein p28); NTPase (EC (NS3) ...
VP2_SVM93 Minor capsid protein VP2
VP3_SVM93 Uncharacterized protein VP3

2 entries

Porcine enteric sapovirus (isolate Swine/United States/Cowden/1980) (Sw/SV/Cowden/1980/US)

POLG_PESV Genome polyprotein [Cleaved into: NS1 (Protein p11); NS2 (Protein p28); NTPase (EC (NS3) ...
VP2_PESV Minor capsid protein VP2

2 entries

Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)

POLG_SVM10 Genome polyprotein [Cleaved into: NS1 (Protein p11); NS2 (Protein p28); NTPase (EC (NS3) ...
VP2_SVM10 Minor capsid protein VP2
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Bat sapovirus TLC58/HK taxid:1185359

Protein ModelArchive
VP2 ma-jd-viral-58991

Sapovirus (strain GII/Human/Japan/Sakai C12/2001) taxid:290314

Protein ModelArchive
ORF2 protein ma-jd-viral-40101