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Vesiculovirus (taxid:11271)

Vesiculovirus is a genus of ssRNA- viruses in the family Rhabdoviridae that infect mammals. These viruses are transmitted by insects (arbovirus) and rarely infect humans in which they cause flu-like disease that can lead to encephalitis.

VIRION

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Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

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Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.
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TAXONOMY Group V: Negative sense ssRNA viruses
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Subphylum: Haploviricotina
Class: Monjiviricetes
Order: Mononegavirales
Family: Rhabdoviridae
Genus: Vesiculovirus
ETYMOLOGY Vesiculovirus: from latin Vesicula: "bladder, blister", symptom induced by Vesicular stomatitis virus.
VIRUS
REFERENCE STRAIN Vesicular stomatitis Indiana virus
Sequence | Genome assembly | Proteome

Host

HOST Human, cattle, horse, swine, sandflies, blackflies
CELL TROPISM VSV: mainly neurons
CELL RECEPTOR (S) Cell receptors:?
Host-virus interaction

Ecology and Disease


GEOGRAPHY
ASSOCIATED DISEASES Vesicular diseases, encephalitis
Human: flu-like symptoms
TRANSMISSION Zoonosis, arthropod bite. Mostly sandflies
VACCINE None
ANTIVIRAL DRUGS

Host-virus interaction

Host gene expression shutoff

Vesicular stomatitis virus matrix protein blocks nuclear pores, resulting in host mRNA nuclear export inhibiton This shutoff of host gene expression prevents effective antiviral response by the infected cell.

NATURAL HOST Vertebrates
TROPISM
ASSOCIATED DISEASES Vesicular diseases, encephalitis Flu-like symptoms in human.
TRANSMISSION VSV: Zoonosis, arthropod bite.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

58 entries grouped by strain

6 entries

Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain

Select_allDeselect_all
MATRX_VSIVA Matrix protein (M protein)

pdb 7UMK; 7UML

PHOSP_VSIVA Phosphoprotein (P protein) (Protein M1)

pdb 2K47; 6U1X

NCAP_VSIVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

pdb 1FZJ; 1FZM; 2GIC; 2QVJ; 2WYY; 3PTO; 3PTX; 3PU0; 3PU1; 3PU4; 5UK4; 6BJY; 6WL2; 6WL3; 6WL4; 7UMK; 7UML; 7UWS

GLYCO_VSIVA Glycoprotein

pdb 3EGD

L_VSIVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

pdb 5A22; 6U1X

C_VSIVA Protein C'

6 entries

Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain

Select_allDeselect_all
L_VSNJO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_VSNJO Phosphoprotein (P protein) (Protein M1)
GLYCO_VSNJO Glycoprotein
MATRX_VSNJO Matrix protein

pdb 2W2R; 7UWS

NCAP_VSNJO Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
C_VSNJO Protein C'

5 entries

Chandipura virus (strain I653514) (CHPV) reference strain

Select_allDeselect_all
L_CHAV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYCO_CHAV Glycoprotein

pdb 4D6W; 5MDM

PHOSP_CHAV Phosphoprotein (Protein P) (Protein M1)
NCAP_CHAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_CHAV Matrix protein

6 entries

Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

Select_allDeselect_all
L_VSIVS RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYCO_VSIVS Glycoprotein
MATRX_VSIVS Matrix protein (M protein)

pdb 4OWR

PHOSP_VSIVS Phosphoprotein (Protein P) (NS) (Protein M1)
C_VSIVS Protein C'
NCAP_VSIVS Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

6 entries

Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)

Select_allDeselect_all
L_VSIVC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYCO_VSIVC Glycoprotein
MATRX_VSIVC Matrix protein (M protein)

pdb 1LG7

PHOSP_VSIVC Phosphoprotein (Protein P) (NS) (Protein M1)
C_VSIVC Protein C'
NCAP_VSIVC Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

6 entries

Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)

Select_allDeselect_all
L_VSIVN RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYCO_VSIVN Glycoprotein
MATRX_VSIVN Matrix protein (M protein)
NCAP_VSIVN Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

pdb 3HHW; 3HHZ

PHOSP_VSIVN Phosphoprotein (Protein P) (NS) (Protein M1)
C_VSIVN Protein C'

5 entries

Isfahan virus (ISFV)

Select_allDeselect_all
L_ISFV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYCO_ISFV Glycoprotein
MATRX_ISFV Matrix protein
PHOSP_ISFV Phosphoprotein (Protein P) (Protein M1)
NCAP_ISFV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

5 entries

Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)

Select_allDeselect_all
MATRX_VSIVG Matrix protein (M protein)
PHOSP_VSIVG Phosphoprotein (Protein P) (Protein M1)
GLYCO_VSIVG Glycoprotein
C_VSIVG Protein C'
NCAP_VSIVG Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

pdb 1KBG; 1NAM; 2MHA; 2VAA

4 entries

Piry virus (PIRYV)

Select_allDeselect_all
MATRX_PIRYV Matrix protein
GLYCO_PIRYV Glycoprotein
NCAP_PIRYV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_PIRYV Phosphoprotein (Protein P) (Protein M1)

4 entries

Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)

Select_allDeselect_all
GLYCO_VSIVM Glycoprotein G

pdb 5I2M; 5I2S; 5OY9

L_VSIVM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

pdb 5CHS

PHOSP_VSIVM Phosphoprotein (Protein P) (Protein M1)

pdb 2FQM; 3HHW; 3HHZ

C_VSIVM Protein C'

2 entries

Vesicular stomatitis New Jersey virus (strain Missouri subtype Hazelhurst) (VSNJV)

Select_allDeselect_all
PHOSP_VSNJM Phosphoprotein (Protein P) (Protein M1)
C_VSNJM Protein C'

1 entry

Cocal virus (COCV)

GLYCO_COCAV Glycoprotein

1 entry

Vesicular stomatitis Indiana virus (strain Orsay) (VSIV)

GLYCO_VSIVO Glycoprotein

1 entry

Vesicular stomatitis New Jersey virus (strain Hazelhurst subtype Hazelhurst) (VSNJV)

L_VSNJH RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Chandipura virus taxid:11272

Protein ModelArchive
Glycoprotein ma-jd-viral-07124
Matrix protein ma-jd-viral-11579
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15201
Phosphoprotein (Protein M1) ma-jd-viral-41126

Chandipura virus (strain I653514) taxid:11273

Protein ModelArchive
Matrix protein ma-jd-viral-11579

Isfahan virus taxid:290008

Protein ModelArchive
Glycoprotein ma-jd-viral-07130
Matrix protein ma-jd-viral-11571
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15172
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-41131

Vesicular stomatitis Alagoas virus taxid:198833

Protein ModelArchive
Glycoprotein ma-jd-viral-07111
Matrix protein ma-jd-viral-11573
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15092
Phosphoprotein (Protein M1) ma-jd-viral-41128

Vesicular stomatitis Indiana virus taxid:11277

Protein ModelArchive
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15153

Vesicular stomatitis Indiana virus (strain 98COE North America) taxid:434488

Protein ModelArchive
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15153

Vesicular stomatitis Indiana virus (strain San Juan) taxid:11285

Protein ModelArchive
Matrix protein (M protein) ma-jd-viral-11572
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15153
Phosphoprotein (P protein) (Protein M1) ma-jd-viral-41125

Vesicular stomatitis New Jersey virus taxid:11280

Protein ModelArchive
Glycoprotein ma-jd-viral-07057
Matrix protein ma-jd-viral-11574
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15178
Phosphoprotein (Protein M1) ma-jd-viral-41130