Carlavirus

VIRION

Non-enveloped, flexuous, filamentous,470-1000 nm or more long and 12-13 nm in diameter.

GENOME

Linear ssRNA(+) genome of 5.8-9 kb in size. The 3' terminus is polyadenylated and, in some genera, the 5' end is capped. Encodes 3 to 6 proteins. RBP is a RNA-binding protein.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA-dependent RNA polymerase (RdRp) is translated directly from the genomic RNA. The other ORFS are transcribed presumably as monocistronic subgenomic mRNAs (sgRNAs).

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated as a monocistronic mRNA to produce the RdRp (encoded by the 5'-proximal ORF).
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Internal subgenomic promoters are used to transcribe the sgRNAs. Traduction of these sgRNAs yields the capsid and movement proteins.
  7. Assembly of new virus particles.
  8. Triple gene block proteins (TGBp) allow cell-to-cell and long-distance movement.

Host-virus interaction

Suppression of RNA silencing

Potato virus M cysteine-rich protein (ORF6) and TGBp1 proteins act as suppressors of RNA silencing, the former inhibiting both local and systemic silencing, whereas the latter inhibits systemic silencing .

Matching UniProtKB/Swiss-Prot entries

32 entries grouped by protein (browse by keywords)

All proteins are shown (view only 7 complete proteome entries)

7 entries

Capsid protein (Coat protein) (CP)

Select_allDeselect_all
CAPSD_PVMR
Potato virus M (strain Russian) (PVM) reference strain
CAPSD_CVB
Chrysanthemum virus B (CVB)
CAPSD_HELVS
Helenium virus S (HelVS)
CAPSD_LSV
Lily symptomless virus (LSV)
CAPSD_POPMV
Poplar mosaic virus (isolate ATCC Pv275) (PMV)
CAPSD_PVMG
Potato virus M (strain German) (PVM)
CAPSD_PVSP
Potato virus S (strain Peruvian)

2 entries

RNA replication polyprotein (223 kDa protein) (ORF1 protein)

Select_allDeselect_all
RDRP_BBSCV
Blueberry scorch virus (BBScV) reference strain
RDRP_PVMR
Potato virus M (strain Russian) (PVM) reference strain

RNA replication polyprotein (ORF1 protein)

5 entries

Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block 1 protein) (TGBp1)

Select_allDeselect_all
TGB1_PVMR
Potato virus M (strain Russian) (PVM) reference strain
TGB1_CVB
Chrysanthemum virus B (CVB)
TGB1_LSV
Lily symptomless virus (LSV)
TGB1_POPMV
Poplar mosaic virus (isolate ATCC Pv275) (PMV)
TGB1_PVSP
Potato virus S (strain Peruvian)

4 entries

Movement protein TGB2 (12 kDa protein) (Triple gene block 2 protein) (TGBp2)

Select_allDeselect_all
TGB2_PVMR
Potato virus M (strain Russian) (PVM) reference strain
TGB2_CVB
Chrysanthemum virus B (CVB)
TGB2_LSV
Lily symptomless virus (LSV)
TGB2_PVSP
Potato virus S (strain Peruvian)

6 entries

Movement protein TGBp3 (7 kDa protein) (Triple gene block 3 protein) (TGBp3)

Select_allDeselect_all
TGB3_PVMR
Potato virus M (strain Russian) (PVM) reference strain
TGB3_CLV
Carnation latent virus (CLV)
TGB3_CVB
Chrysanthemum virus B (CVB)
TGB3_LSV
Lily symptomless virus (LSV)
TGB3_POPMV
Poplar mosaic virus (isolate ATCC Pv275) (PMV)
TGB3_PVSP
Potato virus S (strain Peruvian)

8 entries

RNA silencing suppressor (10.7 kDa protein) (Putative nucleic acid-binding protein)

Select_allDeselect_all
VSR_PVMR
Potato virus M (strain Russian) (PVM) reference strain
VSR_CLV
Carnation latent virus (CLV)

RNA silencing suppressor (11.6 kDa protein) (Putative nucleic acid-binding protein)

VSR_CVB
Chrysanthemum virus B (CVB)

RNA silencing suppressor (12.6 kDa protein) (Putative nucleic acid-binding protein)

VSR_HELVS
Helenium virus S (HelVS)

RNA silencing suppressor (12.6 kDa protein) (Putative nucleic acid-binding protein)

VSR_LSV
Lily symptomless virus (LSV)

RNA silencing suppressor (16 kDa protein) (ORF6 protein) (Putative nucleic acid-binding protein)

VSR_POPMV
Poplar mosaic virus (isolate ATCC Pv275) (PMV)

RNA silencing suppressor (14 kDa protein) (Putative nucleic acid-binding protein)

VSR_PVMG
Potato virus M (strain German) (PVM)

RNA silencing suppressor (12 kDa protein) (Cysteine-rich protein) (CRP) (Nucleic acid-binding regulatory protein) (PR12)

VSR_PVSP
Potato virus S (strain Peruvian)