Inhibition of host STAT1 by virus (kw:KW-1105)
The signal transducer and activator of transcription STAT1 protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT1 in IFN-γ and IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. While IFN-γ induces STAT1 homodimerization, IFN-α/β mainly stimulates heterodimerization of STAT1 and STAT2, both leading to STAT1 activation and nuclear localization.
Many viruses modulate the interferon mediated response by acting on STAT1 using different strategies. The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation. Sendai virus C protein also physically associates with STAT1 and send it to degradation. Vaccinia VH1 phosphatase instead reverses STAT1 activation by interacting with and dephosphorylating STAT1.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)153 entries grouped by protein
4 entries
Protein MGF 360-9L
13 entries
Protein C'
3 entries
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8 entries
Dual specificity protein phosphatase OPG106 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)
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Early E1A protein (Early E1A 20 kDa protein)
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ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)
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Phosphoprotein (Protein P) (Protein M1)
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Genome polyprotein
3 entries
Polyprotein P1234 (P1234) (Non-structural polyprotein) (p270 nonstructural polyprotein)
6 entries
Replicase polyprotein 1ab (ORF1ab polyprotein)
1 entry
Tegument protein UL23
14 entries
Non-structural protein V
1 entry