Inhibition of host STAT1 by virus

The signal transducer and activator of transcription STAT1 protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT1 in IFN-γ and IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. While IFN-γ induces STAT1 homodimerization, IFN-α/β mainly stimulates heterodimerization of STAT1 and STAT2, both leading to STAT1 activation and nuclear localization.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 e1a P vh1 V C

Many viruses modulate the interferon mediated response by acting on STAT1 using different strategies. The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation. Sendai virus C protein also physically associates with STAT1 and send it to degradation. Vaccinia VH1 phosphatase instead reverses STAT1 activation by interacting with and dephosphorylating STAT1.

Matching UniProtKB/Swiss-Prot entries

143 entries grouped by protein (browse by keywords)

13 entries

Protein C'

Select_allDeselect_all
C_SENDA
Sendai virus (strain Hamamatsu) (SeV) reference strain
C_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
C_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

C' protein

C_PI1HB
Human parainfluenza 1 virus (strain C35) (HPIV-1)

Protein C

C_PI1HC
Human parainfluenza 1 virus (strain C39) (HPIV-1)

Protein C

C_PI1HD
Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)

Protein C

C_PI1HE
Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)

Protein C

C_PI3B
Bovine parainfluenza 3 virus (BPIV-3)

Protein C

C_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

Protein C (VP18 protein)

C_SEND6
Sendai virus (strain 6/94) (SeV)
C_SENDF
Sendai virus (strain Fushimi) (SeV)
C_SENDH
Sendai virus (strain Harris) (SeV)
C_SENDN
Sendai virus (strain Nagoya) (SeV)

7 entries

Dual specificity protein phosphatase H1 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)

Select_allDeselect_all
DUSP_FOWPN
Fowlpox virus (strain NVSL) (FPV) reference strain

Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

DUSP_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

DUSP_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
DUSP_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain
DUSP_RACVI
Raccoon poxvirus (RCN)

Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

DUSP_VACCC
Vaccinia virus (strain Copenhagen) (VACV)
DUSP_VARV
Variola virus

14 entries

Early E1A protein (Early E1A 20 kDa protein)

Select_allDeselect_all
E1A_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE04
Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE05
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE07
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE12
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Early E1A protein (Early E1A 29.5 kDa protein)

E1A_ADE40
Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

Early E1A protein (Early E1A 27 kDa protein)

E1A_ADE41
Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

Early E1A protein (Early E1A 27 kDa protein)

E1A_ADEC2
Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)
E1A_ADECC
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))

Early E1A protein (Early E1A 25 kDa protein)

E1A_ADECG
Canine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 (strain Glaxo))
E1A_ADECR
Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))
E1A_ADECT
Canine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine adenovirus 2 (strain Toronto A 26-61))

Early E1A protein (Early E1A 25 kDa protein)

E1A_ADEM1
Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)

Early E1A 21 kDa protein

E1A_ADES7
Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

1 entry

E3 ubiquitin ligase ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

ICP22_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

ORF6 protein (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)

Select_allDeselect_all
NS6_SARS
Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain
NS6_SARS2
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

ORF6 protein (ORF6) (Accessory protein 6) (Non-structural protein 6) (ns6) (Protein X3)

23 entries

Phosphoprotein (Protein P) (Protein M1)

Select_allDeselect_all
PHOSP_ABLVB
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
PHOSP_EBLV1
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
PHOSP_EBLV2
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain
PHOSP_MOKV
Mokola virus (MOKV) reference strain
PHOSP_RABVP
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
PHOSP_RABVS
Rabies virus (strain SAD B19) (RABV) reference strain
PHOSP_WCBV
West Caucasian bat virus (WCBV) reference strain
PHOSP_ABLVH
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
PHOSP_ARAV
Aravan virus (ARAV)
PHOSP_DUVV
Duvenhage virus (DUVV)
PHOSP_IRKV
Irkut virus (IRKV)
PHOSP_KHUV
Khujand virus (KHUV)
PHOSP_LBV
Lagos bat virus (LBV)
PHOSP_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)
PHOSP_RABVB
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
PHOSP_RABVC
Rabies virus (strain CVS-11) (RABV)
PHOSP_RABVD
Rabies virus (strain China/DRV) (RABV)
PHOSP_RABVE
Rabies virus (strain ERA) (RABV)
PHOSP_RABVH
Rabies virus (strain HEP-Flury) (RABV)
PHOSP_RABVI
Rabies virus (strain India) (RABV)
PHOSP_RABVM
Rabies virus (strain PM) (RABV)
PHOSP_RABVN
Rabies virus (strain Nishigahara RCEH) (RABV)
PHOSP_RABVR
Rabies virus (strain China/MRV) (RABV)

60 entries

Genome polyprotein

Select_allDeselect_all
POLG_HCV77
Hepatitis C virus genotype 1a (isolate H77) (HCV) reference strain
POLG_ALKV
Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)
POLG_BANV
Banzi virus (BANV)
POLG_BUSV
Bussuquara virus (BUSV)
POLG_EHV
Edge Hill virus (EHV)
POLG_HCV1
Hepatitis C virus genotype 1a (isolate 1) (HCV)
POLG_HCV6A
Hepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVBB
Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVCO
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
POLG_HCVED
Hepatitis C virus genotype 4a (isolate ED43) (HCV)
POLG_HCVEU
Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVEV
Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)
POLG_HCVH9
Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVIN
Hepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ1
Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)
POLG_HCVJ4
Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
POLG_HCVJ6
Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)
POLG_HCVJ8
Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)
POLG_HCVJA
Hepatitis C virus genotype 1b (isolate Japanese) (HCV)
POLG_HCVJF
Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)
POLG_HCVJK
Hepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVJL
Hepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVJP
Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVJT
Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVK3
Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZ
Hepatitis C virus genotype 3a (isolate NZL1) (HCV)
POLG_HCVR6
Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVSA
Hepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCVT5
Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVTR
Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVTW
Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)
POLG_HCVVA
Hepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVVN
Hepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVVO
Hepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_HCVVP
Hepatitis C virus genotype 6h (isolate VN004) (HCV)
POLG_ILHV
Ilheus virus (ILHV)
POLG_JAEV1
Japanese encephalitis virus (strain SA-14) (JEV)
POLG_JAEV5
Japanese encephalitis virus (strain SA(v)) (JEV)
POLG_JAEVJ
Japanese encephalitis virus (strain Jaoars982) (JEV)
POLG_JAEVM
Japanese encephalitis virus (strain M28) (JEV)
POLG_KFDV
Kyasanur forest disease virus (KFDV)
POLG_KOKV
Kokobera virus (KOKV)
POLG_KUNJM
Kunjin virus (strain MRM61C)
POLG_LANVT
Langat virus (strain TP21)
POLG_LIV
Louping ill virus (Li)
POLG_MCFA
Mosquito cell fusing agent (CFA flavivirus)
POLG_MVEV5
Murray valley encephalitis virus (strain MVE-1-51) (MVEV)
POLG_OHFV
Omsk hemorrhagic fever virus (OHFV)
POLG_POWVL
Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)
POLG_ROCV
Rocio virus (ROCV)
POLG_TBEVH
Tick-borne encephalitis virus (strain Hypr) (TBEV)
POLG_TBEVS
Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)
POLG_TBEVW
Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)
POLG_USUV
Usutu virus (USUV)
POLG_WNV
West Nile virus (WNV)
POLG_WNV9
West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))
POLG_WSLV
Wesselsbron virus (WSLV)
POLG_ZIKVF
Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)

3 entries

Polyprotein P1234 (P1234) (Non-structural polyprotein) (p270 nonstructural polyprotein)

Select_allDeselect_all
POLN_CHIKS
Chikungunya virus (strain S27-African prototype) (CHIKV) reference strain

Polyprotein P1234 (P1234) (Non-structural polyprotein)

POLN_SFV
Semliki forest virus (SFV) reference strain

Polyprotein P1234 (P1234) (Non-structural polyprotein)

POLN_SINDV
Sindbis virus (SINV) reference strain

5 entries

Replicase polyprotein 1ab (ORF1ab polyprotein)

Select_allDeselect_all
RPOA_PRRSB
Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV) reference strain
RPOA_PRRSL
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain
RPOA_PRRS1
Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)
RPOA_PRRSR
Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)
RPOA_PRRSS
Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)

14 entries

Non-structural protein V

Select_allDeselect_all
V_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_NIPAV
Nipah virus reference strain
V_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
V_SV41
Simian virus 41 (SV41) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_MUMP1
Mumps virus (strain SBL-1) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPE
Mumps virus (strain Enders) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPS
Mumps virus (strain SBL) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_PHODV
Phocine distemper virus (PDV)
V_PI4HA
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
V_PI4HB
Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)
V_RINDK
Rinderpest virus (strain Kabete O) (RDV)

1 entry

Membrane-associated protein VP24 (Ebola VP24) (eVP24)

VP24_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain