Modulation of host E3 ubiquitin ligases by virus

Numerous cellular processes are regulated by the reversible conjugation of ubiquitin (UB) or ubiquitin-like (UBL) proteins to substrates. The E3 ubiquitin ligase operates in conjunction with an E1 ubiquitin-activating enzyme and an E2 ubiquitin-conjugating enzyme and transfers ubiquitin to the target substrate. Two types of E3 ubiquitin ligases are present in cells based on the structure of their catalytic domain named RING and HECT. The E3s polyubiquitinate target proteins to a cellular organelle known as the 26S proteasome where substrates are degraded into small peptides. Proteasomal degradation is critical component of many cellular processes including cell cycle regulation,induction of the inflammatory response and antigen presentation.

Several viruses encode viral E3 ligases in order to direct specific substrates for proteasomal degradation. For example, herpes simplex virus encodes ICPO which acts as a nuclear E3 ubiquitin ligase that polyubiquitinates the nuclear bodies-associated PML and Sp100 proteins.

Matching UniProtKB/Swiss-Prot entries

25 entries grouped by protein (browse by keywords)

2 entries

Ankyrin repeat domain-containing protein CP77 (Host range protein 1)

Select_allDeselect_all
CP77_CWPXB
Cowpox virus (strain Brighton Red) (CPV) reference strain
CP77_COWPX
Cowpox virus (CPV)

7 entries

Early E1A protein (Early E1A 27 kDa protein)

Select_allDeselect_all
E1A_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE05
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE04
Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE07
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE12
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Early E1A protein (Early E1A 29.5 kDa protein)

E1A_ADE40
Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)
E1A_ADE41
Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

7 entries

Kelch repeat and BTB domain-containing protein 1

Select_allDeselect_all
KBTB1_CAMPS
Camelpox virus (strain CMS) reference strain
KBTB1_CWPXB
Cowpox virus (strain Brighton Red) (CPV) reference strain
KBTB1_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

Kelch repeat and BTB domain-containing protein A55

KBTB1_CWPXG
Cowpox virus (strain GRI-90 / Grishak) (CPV)
KBTB1_ECTVM
Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)
KBTB1_HSPV
Horsepox virus (HSPV)
KBTB1_VACCC
Vaccinia virus (strain Copenhagen) (VACV)

4 entries

Kelch repeat and BTB domain-containing protein 2

Select_allDeselect_all
KBTB2_CWPXB
Cowpox virus (strain Brighton Red) (CPV) reference strain
KBTB2_CWPXG
Cowpox virus (strain GRI-90 / Grishak) (CPV)
KBTB2_ECTVM
Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)
KBTB2_HSPV
Horsepox virus (HSPV)

3 entries

Latent membrane protein 2 (Terminal protein)

Select_allDeselect_all
LMP2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LMP2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

1 entry

Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

LT_SV40
Simian virus 40 (SV40) reference strain

1 entry

Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)

MT5_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain