Modulation of host ubiquitin pathway by viral deubiquitinase (kw:KW-1127)
Numerous cellular processes are regulated by the reversible conjugation of ubiquitin (UB) or ubiquitin-like (UBL) proteins to substrates. The human genome encodes several DUBs or deubiquitinating enzymes which oppose the function of E3 ligases. Several keys functions have been attributed to deubiquitinating enzymes:
- Deubiquitination can rescue proteins from degradation
- Deubiquitination can remove a non degradative signal used by cells
- Action together with E3 ligases maintain the normal intracellular pool of ubiquitin.

Several viruses encode viral deubiquitinases. One of the functions of these viral deubiquitinases is to prevent host innate response activation. For example, EBV-encoded BPLF1 interacts with and deubiquitinates TRAF6 to inhibit NF-kB signaling during viral infection. KSHV ORF64, a protein with deubiquitinase (DUB) activity, suppresses RIG-I-mediated IFN signaling by reducing the ubiquitination of RIG-I, essential for its activation. PLP2 protein from murine hepatitis virus, strongly inhibits cellular type I interferon production.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)94 entries grouped by strain
2 entries
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
2 entries
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
2 entries
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
2 entries
Human coronavirus 229E (HCoV-229E) reference strain
2 entries
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1) reference strain
2 entries
Human coronavirus NL63 (HCoV-NL63) reference strain
2 entries
Human coronavirus OC43 (HCoV-OC43) reference strain
2 entries
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1) reference strain
2 entries
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
2 entries
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
2 entries
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
2 entries
Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain
2 entries
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain
1 entry
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain
1 entry
Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV) reference strain
1 entry
Dugbe virus (isolate ArD44313) (DUGV) reference strain
1 entry
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
1 entry
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
1 entry
Equine arteritis virus (strain Bucyrus) (EAV) reference strain
1 entry
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain
1 entry
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain
1 entry
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
1 entry
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain
1 entry
Grapevine fleck virus (isolate Italy/MT48) (GFkV) reference strain
1 entry
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
1 entry
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
1 entry
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
1 entry
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
1 entry
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
1 entry
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
1 entry
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
1 entry
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
1 entry
Maize rayado fino virus (isolate Costa Rica/Guapiles) (MRFV) reference strain
1 entry
Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus) reference strain
1 entry
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain
1 entry
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain
1 entry
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain
1 entry
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
1 entry
Turnip yellow mosaic virus reference strain
1 entry
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain
2 entries
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
2 entries
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
2 entries
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
2 entries
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
2 entries
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
2 entries
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
2 entries
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
2 entries
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
2 entries
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
2 entries
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1)
2 entries
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
2 entries
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
2 entries
Porcine epidemic diarrhea virus (strain CV777) (PEDV)
1 entry
Eggplant mosaic virus
1 entry
Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)
1 entry
Erysimum latent virus (ELV)
1 entry
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
1 entry
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
1 entry
Kennedya yellow mosaic virus (strain Jervis bay) (KYMV)
1 entry
Ononis yellow mosaic virus
1 entry
Porcine reproductive and respiratory syndrome virus (PRRSV)
1 entry
Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)
1 entry
Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)
1 entry
Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV)
1 entry
Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)
1 entry
Turnip yellow mosaic virus (isolate Australia)
1 entry
Turnip yellow mosaic virus (isolate TYMC)
1 entry