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Viral long flexible tail ejection system (kw:KW-1243)

The long and flexible tail of Siphoviridae acts as a molecular machine that ejects the viral DNA from the capsid into the host cell cytoplasm. The ejection system consists of a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid .

Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm.

The source of the forces that drive viral genome ejection is probably in part due to osmotic pressure imbalance between the virus inside and the host cytoplasm .

Gram(-) hosts:

image

  1. Attachment to a host cell outer membrane (OM) receptor.
  2. Tail tip penetrates into host OM. Virion-associated exolysin (if present) hydrolyzes the peptidoglycan layer.
  3. Tail reaches host plasma membrane. Possible loss of tail tip.
  4. Creation (fusogenic activity?) or use of a hydrophilic pore for viral DNA translocation into host cytoplasm.

Gram(+) hosts:

image

  1. Attachment to a host cell wall receptor.
  2. Tip-associated hydrolysis of the peptidoglycan layer.
  3. Tail reaches host plasma membrane. Possible loss of tail tip. Opening of the cap.
  4. Creation (fusogenic activity?) or use of a hydrophilic pore for viral DNA translocation into host cytoplasm.
Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Ejection Short tail ejection system
Long flexible tail ejection system
Contractile tail ejection system
Links Uniprot Keyword: KW-1243
GO ontology:GO:0099001
Virus Siphoviridae

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

46 entries grouped by strain

7 entries

Escherichia phage lambda (Bacteriophage lambda) reference strain

Select_allDeselect_all
PORTL_LAMBD Portal protein B (GpB) (Minor capsid protein B) [Cleaved into: Protein B*]

pdb 8K38; 8K39; 8XOT; 8XOU; 8XOW; 8XPM; 8XQB

TMP_LAMBD Tape measure protein (TMP) (Gene product H) (gpH) (Minor tail protein H) [Cleaved into: Entry ...

pdb 8IYK; 8IYL; 8K35

TIPL_LAMBD Tail tip protein L

pdb 8IYK; 8IYL; 8K35; 8XCG

TIPJ_LAMBD Tip attachment protein J (Central tail fiber) (Host specificity protein J) (gpJ protein)

pdb 8IYK; 8IYL; 8JVM; 8K35; 8XCG; 8XCI; 8XCJ; 8XCK

TTTP_LAMBD Tail tube terminator protein (TrP) (Gene product U) (gpU) (Minor tail protein U) (Tail ...

pdb 1Z1Z; 3FZ2; 3FZB; 8IYD; 8K37; 8XOW; 8XPM; 8XQB

TUBE_LAMBD Tail tube protein (TTP) (Gene product V) (gpV) (Major tail protein V)

pdb 2K4Q; 2L04; 6P3E; 7T2E; 7T4F; 8IYD; 8IYK; 8IYL; 8K35; 8K36; 8K37; 8KGE; 8XPM

TIPM_LAMBD Tail tip protein M

pdb 8IYK; 8IYL; 8K35; 8XCG

6 entries

Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

Select_allDeselect_all
TUBE_BPSPP Tail tube protein gp17.1* (TTP) (Gene product 17.1) (gp17.1) (Major tail protein) (MTP)

pdb 5A20; 5A21; 6YEG; 6YQ5

PORTL_BPSPP Portal protein (Gene product 6) (gp6) (Portal vertex protein)

pdb 2JES; 5A20; 5A21; 7Z4W

HCP16_BPSPP Head completion protein gp16 (Connector protein gp16) (Gene product 16) (Gp16) (Stopper protein ...

pdb 2KCA; 5A20; 5A21; 7Z4W

FIBER_BPSPP Tail spike protein (TSP) (Gene product 21) (Gp21)
DIT_BPSPP Distal tail protein (Dit) (Gene product 19.1) (Gp19.1)

pdb 2X8K

HCP15_BPSPP Head completion protein gp15 (HCP) (Connector protein gp15) (Gene product 15) (Gp15)

pdb 2KBZ; 5A20; 5A21; 7Z4W

6 entries

Lactococcus phage SK1 (Lactococcus lactis bacteriophage SK1) reference strain

Select_allDeselect_all
PORTL_BPLSK Probable portal protein (Gene product 4) (gp4) (Putative portal protein)
HCP1_BPLSK Probable head completion protein 1 (HCP1) (Connector protein gp8) (Putative connector protein gp8)
HCP2_BPLSK Probable head completion protein 2 (Connector protein gp9) (Gene product 9) (gp9) (Putative stopper ...
TUBE_BPLSK Tail tube protein (TTP) (Gene product 11) (gp11) (Major tail protein) (MTP)
DIT_BPLSK Distal tail protein (Dit) (Gene product 15) (Gp15)
GP16_BPLSK Baseplate protein gp16 (Exolysin) (Gene product 16) (Gp16) (Tail lysozyme-like) (Tail-associated ...

5 entries

Escherichia phage N15 (Bacteriophage N15) reference strain

Select_allDeselect_all
TIPL_BPN15 Tail tip protein L (Gene product 18) (gp18)
PORTL_BPN15 Portal protein [Cleaved into: Protein B*]
TTTP_BPN15 Tail tube terminator protein (TrP) (Gene product 12) (gp12) (Tail-to-head joining protein) (THJP)
TMP_BPN15 Tape measure protein (TMP) (Gene product 16) (gp16)
TIPM_BPN15 Tail tip protein M (Gene product 17) (gp17)

4 entries

Escherichia phage T5 (Enterobacteria phage T5) reference strain

Select_allDeselect_all
TMP_BPT5 Tape measure protein pb2 precursor (TMP-pb2) (Pore-forming protein pb2) (Tail protein pb2) [Cleaved ...

pdb 7ZHJ; 7ZN2; 7ZQB; 7ZQP

PORTL_BPT5 Portal protein (Capsid protein pb7)

pdb 9ILP; 9IMV

TTTP_BPT5 Tail tube terminator protein p142 (TrP-142) (Tail protein p142) (Tail-to-head joining protein p142) ...

pdb 8BCP; 8BCU; 9ILV; 9IMH

TUBE_BPT5 Tail tube protein pb6 (TTP-pb6) (Major tail protein pb6) (MTP pb6) (Tail protein pb6)

pdb 5NGJ; 7QG9; 7ZHJ; 7ZN2; 7ZQB; 8BCP; 8BCU; 9INY

2 entries

Enterobacteria phage HK97 (Bacteriophage HK97) reference strain

Select_allDeselect_all
GP6_BPHK7 Head completion protein gp6 (Connector protein gp6) (Gene product 6) (Gp6)

pdb 3JVO

GP7_BPHK7 Head completion protein gp7 (Connector protein gp7) (Gene product 7) (Gp7) (Stopper protein gp7)

1 entry

Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta) reference strain

TMP_BPSPB Probable tape measure protein (TMP) (Transglycosylase) (EC 4.2.2.n1)

1 entry

Escherichia phage T1 (Bacteriophage T1) reference strain

TMP_BPT1 Tape measure protein (TMP) (Gene product 38) (gp38)

pdb 9L9P

1 entry

Mycobacterium phage D29 (Mycobacteriophage D29) reference strain

PORTL_BPMD2 Portal protein (Gene product 14) (gp14) (Portal vertex protein)

1 entry

Mycobacterium phage L5 (Mycobacteriophage L5) reference strain

PORTL_BPML5 Portal protein (Gene product 14) (gp14) (Portal vertex protein)

1 entry

Pseudomonas phage PAJU2 reference strain

TMP_BPPAJ Tape measure protein (TMP) (ORF10 protein) (Structural protein 1)

1 entry

Streptomyces phage phiC31 (Bacteriophage phi-C31) reference strain

PORTL_BPPHC Probable portal protein

6 entries

Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)

Select_allDeselect_all
GP16_BPLP2 Baseplate protein gp16 (Gene product 16) (Gp16) (Tail-associated lysine-like protein)

pdb 2WZP; 6ZIG; 6ZIH; 6ZJJ

DIT_BPLP2 Distal tail protein (Dit) (Gene product 15) (Gp15)

pdb 2WZP; 2X53; 6ZIG; 6ZIH; 6ZJJ

TUBE_BPLP2 Tail tube protein (TTP) (Gene product 11) (gp11) (Major tail protein) (MTP)
PORTL_BPLP2 Probable portal protein (Gene product 4) (gp4)
HCP1_BPLP2 Probable head completion protein 1 (HCP1) (Connector protein gp8)
HCP2_BPLP2 Probable head completion protein 2 (Connector protein gp9) (Gene product 9) (gp9) (Stopper protein ...

1 entry

Enterobacteria phage HK97 (Bacteriophage HK97)

PORTL_BPHK7 Portal protein (GP3)

pdb 8CEZ; 8FQL

1 entry

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

PORTL_BPP21 Portal protein B (GpB) (Minor capsid protein B)

1 entry

Escherichia phage SECphi27

TIPJ_BPS27 Tip attachment protein J (Central tail fiber) (CTF) (gpJ protein)

1 entry

Lactococcus phage F4-1 (Lactococcus lactis bacteriophage F4-1)

TUBE_BPF41 Tail tube protein (TTP) (Major tail protein) (MTP)