Viral long flexible tail ejection system

The long and flexible tail of Siphoviridae acts as a molecular machine that ejects the viral DNA from the capsid into the host cell cytoplasm. The ejection system consists of a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid .

Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm.

The source of the forces that drive viral genome ejection is probably in part due to osmotic pressure imbalance between the virus inside and the host cytoplasm .

Gram(-) hosts:

image

  1. Attachment to a host cell outer membrane (OM) receptor.
  2. Tail tip penetrates into host OM. Virion-associated exolysin (if present) hydrolyzes the peptidoglycan layer.
  3. Tail reaches host plasma membrane. Possible loss of tail tip.
  4. Creation (fusogenic activity?) or use of a hydrophilic pore for viral DNA translocation into host cytoplasm.

Gram(+) hosts:

image

  1. Attachment to a host cell wall receptor.
  2. Tip-associated hydrolysis of the peptidoglycan layer.
  3. Tail reaches host plasma membrane. Possible loss of tail tip. Opening of the cap.
  4. Creation (fusogenic activity?) or use of a hydrophilic pore for viral DNA translocation into host cytoplasm.

Matching UniProtKB/Swiss-Prot entries

43 entries grouped by strain (browse by keywords)

7 entries

Escherichia phage lambda (Bacteriophage lambda) reference strain

Select_allDeselect_all
TIPJ_LAMBD Tip attachment protein J (Central tail fiber) (Host specificity protein J)
PORTL_LAMBD Portal protein B (GpB) (Minor capsid protein B) [Cleaved into: Protein B*]
TTTP_LAMBD Tail tube terminator protein (TrP) (Gene product U) (gpU) (Minor tail protein U) (Tail ...
TMP_LAMBD Tape measure protein (TMP) (Gene product H) (gpH) (Minor tail protein H) [Cleaved into: Entry ...
TUBE_LAMBD Tail tube protein (TTP) (Gene product V) (gpV) (Major tail protein V)
TIPL_LAMBD Tail tip protein L
TIPM_LAMBD Tail tip protein M

6 entries

Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

Select_allDeselect_all
TUBE_BPSPP Tail tube protein gp17.1* (TTP) (Gene product 17.1) (gp17.1) (Major tail protein) (MTP)
PORTL_BPSPP Portal protein (Gene product 6) (gp6) (Portal vertex protein)
HCP15_BPSPP Head completion protein gp15 (HCP) (Connector protein gp15) (Gene product 15) (Gp15)
FIBER_BPSPP Tail spike protein (TSP) (Gene product 21) (Gp21)
DIT_BPSPP Distal tail protein (Dit) (Gene product 19.1) (Gp19.1)
HCP16_BPSPP Head completion protein gp16 (Connector protein gp16) (Gene product 16) (Gp16) (Stopper protein ...

6 entries

Lactococcus phage SK1 (Lactococcus lactis bacteriophage SK1) reference strain

Select_allDeselect_all
TUBE_BPLSK Tail tube protein (TTP) (Gene product 11) (gp11) (Major tail protein) (MTP)
HCP2_BPLSK Probable head completion protein 2 (Connector protein gp9) (Gene product 9) (gp9) (Putative stopper ...
DIT_BPLSK Distal tail protein (Dit) (Gene product 15) (Gp15)
GP16_BPLSK Baseplate protein gp16 (Exolysin) (Gene product 16) (Gp16) (Tail lysozyme-like) (Tail-associated ...
HCP1_BPLSK Probable head completion protein 1 (HCP1) (Connector protein gp8) (Putative connector protein gp8)
PORTL_BPLSK Probable portal protein (Gene product 4) (gp4) (Putative portal protein)

6 entries

Lactococcus phage p2 (Lactococcus lactis bacteriophage p2) reference strain

Select_allDeselect_all
GP16_BPLP2 Baseplate protein gp16 (Gene product 16) (Gp16) (Tail-associated lysine-like protein)
TUBE_BPLP2 Tail tube protein (TTP) (Gene product 11) (gp11) (Major tail protein) (MTP)
PORTL_BPLP2 Probable portal protein (Gene product 4) (gp4)
DIT_BPLP2 Distal tail protein (Dit) (Gene product 15) (Gp15)
HCP1_BPLP2 Probable head completion protein 1 (HCP1) (Connector protein gp8)
HCP2_BPLP2 Probable head completion protein 2 (Connector protein gp9) (Gene product 9) (gp9) (Stopper protein ...

5 entries

Escherichia phage N15 (Bacteriophage N15) reference strain

Select_allDeselect_all
TIPL_BPN15 Tail tip protein L (Gene product 18) (gp18)
TMP_BPN15 Tape measure protein (TMP) (Gene product 16) (gp16)
TTTP_BPN15 Tail tube terminator protein (TrP) (Gene product 12) (gp12) (Tail-to-head joining protein) (THJP)
PORTL_BPN15 Portal protein [Cleaved into: Protein B*]
TIPM_BPN15 Tail tip protein M (Gene product 17) (gp17)

4 entries

Escherichia phage T5 (Enterobacteria phage T5) reference strain

Select_allDeselect_all
PORTL_BPT5 Portal protein (Capsid protein pb7)
TTTP_BPT5 Tail tube terminator protein (TrP) (Tail protein p142) (Tail-to-head joining protein) (THJP)
TMP_BPT5 Probable tape measure protein (Tail protein pb2)
TUBE_BPT5 Tail tube protein (TTP) (Tail protein pb6)

1 entry

Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta) reference strain

TMP_BPSPB Probable tape measure protein (TMP) (Transglycosylase) (EC 4.2.2.n1)

1 entry

Escherichia phage T1 (Bacteriophage T1) reference strain

TMP_BPT1 Tape measure protein (TMP) (Gene product 38) (gp38)

1 entry

Mycobacterium phage D29 (Mycobacteriophage D29) reference strain

PORTL_BPMD2 Portal protein (Gene product 14) (gp14) (Portal vertex protein)

1 entry

Mycobacterium phage L5 (Mycobacteriophage L5) reference strain

PORTL_BPML5 Portal protein (Gene product 14) (gp14) (Portal vertex protein)

1 entry

Pseudomonas phage PAJU2 reference strain

TMP_BPPAJ Tape measure protein (TMP) (ORF10 protein) (Structural protein 1)

1 entry

Streptomyces phage phiC31 (Bacteriophage phi-C31) reference strain

PORTL_BPPHC Probable portal protein

1 entry

Enterobacteria phage HK97 (Bacteriophage HK97)

PORTL_BPHK7 Portal protein (GP3)

1 entry

Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

PORTL_BPP21 Portal protein B (GpB) (Minor capsid protein B)

1 entry

Lactococcus phage F4-1 (Lactococcus lactis bacteriophage F4-1)

TUBE_BPF41 Tail tube protein (TTP) (Major tail protein) (MTP)