Viral long flexible tail ejection system

The long and flexible tail of Siphoviridae acts as a molecular machine that ejects the viral DNA from the capsid into the host cell cytoplasm. The ejection system consists of a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid .

Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm.

The source of the forces that drive viral genome ejection is probably in part due to osmotic pressure imbalance between the virus inside and the host cytoplasm .

Gram(-) hosts:

  1. Attachment to a host cell outer membrane (OM) receptor.
  2. Tail tip penetrates into host OM. Virion-associated exolysin (if present) hydrolyzes the peptidoglycan layer.
  3. Tail reaches host plasma membrane. Possible loss of tail tip.
  4. Creation (fusogenic activity?) or use of a hydrophilic pore for viral DNA translocation into host cytoplasm.

Gram(+) hosts:

  1. Attachment to a host cell wall receptor.
  2. Tip-associated hydrolysis of the peptidoglycan layer.
  3. Tail reaches host plasma membrane. Possible loss of tail tip. Opening of the cap.
  4. Creation (fusogenic activity?) or use of a hydrophilic pore for viral DNA translocation into host cytoplasm.

Matching UniProtKB/Swiss-Prot entries

41 entries grouped by protein (browse by keywords)

All proteins are shown (view only 38 complete proteome entries)

3 entries

Distal tail protein (Dit) (Gene product 15) (Gp15)

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DIT_BPLSK
Lactococcus phage SK1 (Lactococcus lactis bacteriophage SK1) reference strain
DIT_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

Distal tail protein (Dit) (Gene product 19.1) (Gp19.1)

DIT_BPLP2
Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)

1 entry

Tail spike protein (TSP) (Gene product 21) (Gp21)

FIBER_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

2 entries

Baseplate protein gp16 (Exolysin) (Gene product 16) (Gp16) (Tail lysozyme-like) (Tail-associated lysine-like protein)

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GP16_BPLSK
Lactococcus phage SK1 (Lactococcus lactis bacteriophage SK1) reference strain
GP16_BPLP2
Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)

Baseplate protein gp16 (Gene product 16) (Gp16) (Tail-associated lysine-like protein)

2 entries

Probable head completion protein 1 (HCP1) (Connector protein gp8)

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HCP1_BPLSK
Lactococcus phage SK1 (Lactococcus lactis bacteriophage SK1) reference strain

Probable head completion protein 1 (HCP1) (Connector protein gp8) (Putative connector protein gp8)

HCP1_BPLP2
Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)

1 entry

Head completion protein gp15 (HCP) (Connector protein gp15) (Gene product 15) (Gp15)

HCP15_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

1 entry

Head completion protein gp16 (Connector protein gp16) (Gene product 16) (Gp16) (Stopper protein gp16)

HCP16_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

2 entries

Probable head completion protein 2 (Connector protein gp9) (Gene product 9) (gp9) (Putative stopper protein gp9) (Stopper protein gp9)

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HCP2_BPLSK
Lactococcus phage SK1 (Lactococcus lactis bacteriophage SK1) reference strain
HCP2_BPLP2
Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)

Probable head completion protein 2 (Connector protein gp9) (Gene product 9) (gp9) (Stopper protein gp9)

12 entries

Portal protein (Gene product 14) (gp14) (Portal vertex protein)

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PORTL_BPLSK
Lactococcus phage SK1 (Lactococcus lactis bacteriophage SK1) reference strain

Probable portal protein (Gene product 4) (gp4) (Putative portal protein)

PORTL_BPMD2
Mycobacterium phage D29 (Mycobacteriophage D29) reference strain
PORTL_BPML5
Mycobacterium phage L5 (Mycobacteriophage L5) reference strain
PORTL_BPN15
Escherichia phage N15 (Bacteriophage N15) reference strain

Probable portal protein

PORTL_BPPHC
Streptomyces phage phiC31 (Bacteriophage phi-C31) reference strain

Probable portal protein

PORTL_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

Portal protein (Gene product 6) (gp6) (Portal vertex protein)

PORTL_BPT1
Escherichia phage T1 (Bacteriophage T1) reference strain

Portal protein (Gene product 26) (Gp26) (Head-to-tail connector)

PORTL_BPT5
Escherichia phage T5 (Enterobacteria phage T5) reference strain

Portal protein (Capsid protein pb7)

PORTL_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

Portal protein B (GpB) (Minor capsid protein B)

PORTL_BPHK7
Enterobacteria phage HK97 (Bacteriophage HK97)

Portal protein (GP3)

PORTL_BPLP2
Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)

Probable portal protein (Gene product 4) (gp4)

PORTL_BPP21
Enterobacteria phage P21 (Bacteriophage 21) (Bacteriophage P21)

Portal protein (Head protein Gp4)

1 entry

Tip attachment protein J (Central tail fiber) (Host specificity protein J)

TIPJ_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

2 entries

Tail tip protein L

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TIPL_BPN15
Escherichia phage N15 (Bacteriophage N15) reference strain

Tail tip protein L (Gene product 18) (gp18)

TIPL_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

2 entries

Tail tip protein M

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TIPM_BPN15
Escherichia phage N15 (Bacteriophage N15) reference strain

Tail tip protein M (Gene product 17) (gp17)

TIPM_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

3 entries

Probable tape measure protein (TMP) (Transglycosylase) (EC 4.2.2.n1)

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TMP_BPSPB
Bacillus phage SPbeta (Bacillus phage SPBc2) (Bacteriophage SP-beta) reference strain
TMP_BPT5
Escherichia phage T5 (Enterobacteria phage T5) reference strain

Probable tape measure protein (Tail protein pb2)

TMP_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

Tape measure protein (TMP) (Gene product H) (gpH) (Minor tail protein H)

3 entries

Tail tube terminator protein (TrP) (Gene product 12) (gp12) (Tail-to-head joining protein) (THJP)

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TTTP_BPN15
Escherichia phage N15 (Bacteriophage N15) reference strain
TTTP_BPT5
Escherichia phage T5 (Enterobacteria phage T5) reference strain

Tail tube terminator protein (TrP) (Tail protein p142) (Tail-to-head joining protein) (THJP)

TTTP_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

Tail tube terminator protein (TrP) (Gene product U) (gpU) (Minor tail protein U) (Tail sheath-stabilizing protein) (Tail-to-head joining protein) (THJP)

6 entries

Tail tube protein (TTP) (Gene product 11) (gp11) (Major tail protein) (MTP)

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TUBE_BPLSK
Lactococcus phage SK1 (Lactococcus lactis bacteriophage SK1) reference strain
TUBE_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

Tail tube protein gp17.1* (TTP) (Gene product 17.1) (gp17.1) (Major tail protein) (MTP)

TUBE_BPT5
Escherichia phage T5 (Enterobacteria phage T5) reference strain

Tail tube protein (TTP) (Tail protein pb6)

TUBE_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

Tail tube protein (TTP) (Gene product V) (gpV) (Major tail protein V)

TUBE_BPF41
Lactococcus phage F4-1 (Lactococcus lactis bacteriophage F4-1)

Tail tube protein (TTP) (Major tail protein) (MTP)

TUBE_BPLP2
Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)