Viral genome circularization (kw:KW-1253)

Circularization of infecting DNA within the host cell is a rather common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome.
Circularization, also known as cyclization, can be mediated by covalent closure of the DNA "sticky" ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities.


Virus Family Circularization mechanism Viral proteinRef.
Phage Mu Myoviridae Circularization protein (non-covalent) Protein N
Phage lambda Siphoviridae Cohesive (sticky) ends -
Phage P22 Podoviridae Recombinaison -
Phage P1 Myoviridae Recombinaison Cre
Phage N15 Siphoviridae Cohesive (sticky) ends -

Matching UniProtKB/Swiss-Prot entries

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6 entries grouped by protein

1 entry

DNA circularization protein N (64 kDa virion protein) (Gene product 43) (gp43) (Gene product N) (gpN)

Escherichia phage Mu (Bacteriophage Mu) reference strain

2 entries

Protein Ku (Cd-Ku) (Gp87)

Mycobacterium phage Corndog (Mycobacteriophage Corndog) reference strain
Mycobacterium phage Omega (Mycobacteriophage Omega) reference strain

Protein Ku (Gp206) (Omega-Ku)

3 entries

Maturation protein A (MP) (Assembly protein) (A protein)

Enterobacteria phage GA (Bacteriophage GA) reference strain
Escherichia phage MS2 (Bacteriophage MS2) reference strain
Enterobacteria phage fr (Bacteriophage fr)