Inhibition of host TBK1 by virus

Following activation of toll-like receptors by viral components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB.

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Several viruses including herpesviruses or poxviruses interact directly with and inhibit TBK1 to prevent IRFs activation.

Inhibition of host TLR pathway Inhibition of host TBK1
Links Uniprot Keyword: KW-1223
GO ontology: GO:0039723
Virus -Herpes virus 1
(Herpesviridae, simplexvirus)

-Murine gammaherpesvirus 68 (MHV-4)
(Herpesviridae, rhadinovirus)

-Vaccinia virus
(Poxviridae, orthopoxvirus )

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

34 entries grouped by protein (browse by keywords)

3 entries

Protein MGF 360-11L

Select_allDeselect_all
36011_ASFK5
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
36011_ASFM2
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
36011_ASFP4
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)

1 entry

Protein C6

C6_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

3 entries

TBK1 inhibitor DP96R

Select_allDeselect_all
DP96R_ASFB7
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain
DP96R_ASFK5
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
DP96R_ASFP4
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)

7 entries

Non-structural protein 1 (Non-structural protein 1C)

Select_allDeselect_all
NS1_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS1_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2) reference strain

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSVA
Human respiratory syncytial virus A (strain A2) reference strain

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NS1_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS1_HRSVL
Human respiratory syncytial virus A (strain Long)
NS1_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

6 entries

Non-structural protein 2 (NS2) (Non-structural protein 1B)

Select_allDeselect_all
NS2_BRSVA
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
NS2_HRSVA
Human respiratory syncytial virus A (strain A2) reference strain
NS2_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
NS2_HRSV1
Human respiratory syncytial virus B (strain 18537)
NS2_HRSVL
Human respiratory syncytial virus A (strain Long)
NS2_ORSVW
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

2 entries

Non-structural protein NS-S (NSs)

Select_allDeselect_all
NSS_SFTSV
SFTS phlebovirus (isolate SFTSV/Human/China/HB29/2010) (Severe fever with thrombocytopenia virus) reference strain
NSS_HTRV
Heartland virus (HTRV)

1 entry

Phosphoprotein (P protein) (p23) (p24)

PHOSP_BDVV
Borna disease virus (strain V) (BDV) reference strain

2 entries

Genome polyprotein

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POLG_SVV1
Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain

1 entry

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

R1AB_SARS2
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

pdb 5R7Y; 5R7Z; 5R80; 5R81; 5R82; 5R83; 5R84; 5R8T; 5RE4; 5RE5; 5RE6; 5RE7; 5RE8; 5RE9; 5REA; 5REB; 5REC; 5RED; 5REE; 5REF; 5REG; 5REH; 5REI; 5REJ; 5REK; 5REL; 5REM; 5REN; 5REO; 5REP; 5RER; 5RES; 5RET; 5REU; 5REV; 5REW; 5REX; 5REY; 5REZ; 5RF0; 5RF1; 5RF2; 5RF3; 5RF4; 5RF5; 5RF6; 5RF7; 5RF8; 5RF9; 5RFA; 5RFB; 5RFC; 5RFD; 5RFE; 5RFF; 5RFG; 5RFH; 5RFI; 5RFJ; 5RFK; 5RFL; 5RFM; 5RFN; 5RFO; 5RFP; 5RFQ; 5RFR; 5RFS; 5RFT; 5RFU; 5RFV; 5RFW; 5RFX; 5RFY; 5RFZ; 5RG0; 5RG1; 5RG2; 5RG3; 5RGG; 5RGH; 5RGI; 5RGJ; 5RGK; 5RGL; 5RGM; 5RGN; 5RGO; 5RGP; 5RGQ; 5RGR; 5RGS; 5RGT; 5RGU; 5RGV; 5RGW; 5RGX; 5RGY; 5RGZ; 5RH0; 5RH1; 5RH2; 5RH3; 5RH4; 5RH5; 5RH6; 5RH7; 5RH8; 5RH9; 5RHA; 5RHB; 5RHC; 5RHD; 5RHE; 5RHF; 5RL0; 5RL1; 5RL2; 5RL3; 5RL4; 5RL5; 5RL6; 5RL7; 5RL8; 5RL9; 5RLB; 5RLC; 5RLD; 5RLE; 5RLF; 5RLG; 5RLH; 5RLI; 5RLJ; 5RLK; 5RLL; 5RLM; 5RLN; 5RLO; 5RLP; 5RLQ; 5RLR; 5RLS; 5RLT; 5RLU; 5RLV; 5RLW; 5RLY; 5RLZ; 5RM0; 5RM1; 5RM2; 5RM3; 5RM4; 5RM5; 5RM6; 5RM7; 5RM8; 5RM9; 5RMA; 5RMB; 5RMC; 5RMD; 5RME; 5RMF; 5RMG; 5RMH; 5RMI; 5RMJ; 5RMK; 5RML; 5RMM; 5ROB; 5RS7; 5RS8; 5RS9; 5RSB; 5RSC; 5RSD; 5RSE; 5RSF; 5RSG; 5RSH; 5RSI; 5RSJ; 5RSK; 5RSL; 5RSM; 5RSN; 5RSO; 5RSP; 5RSQ; 5RSR; 5RSS; 5RST; 5RSU; 5RSV; 5RSW; 5RSX; 5RSY; 5RSZ; 5RT0; 5RT1; 5RT2; 5RT3; 5RT4; 5RT5; 5RT6; 5RT7; 5RT8; 5RT9; 5RTA; 5RTB; 5RTC; 5RTD; 5RTE; 5RTF; 5RTG; 5RTH; 5RTI; 5RTJ; 5RTK; 5RTL; 5RTM; 5RTN; 5RTO; 5RTP; 5RTQ; 5RTR; 5RTS; 5RTT; 5RTU; 5RTV; 5RTW; 5RTX; 5RTY; 5RTZ; 5RU0; 5RU1; 5RU2; 5RU3; 5RU4; 5RU5; 5RU6; 5RU7; 5RU8; 5RU9; 5RUA; 5RUC; 5RUD; 5RUE; 5RUF; 5RUG; 5RUH; 5RUI; 5RUJ; 5RUK; 5RUL; 5RUM; 5RUN; 5RUO; 5RUP; 5RUQ; 5RUR; 5RUS; 5RUT; 5RUU; 5RUV; 5RUW; 5RUX; 5RUY; 5RUZ; 5RV0; 5RV1; 5RV2; 5RV3; 5RV4; 5RV5; 5RV6; 5RV7; 5RV8; 5RV9; 5RVA; 5RVB; 5RVC; 5RVD; 5RVE; 5RVF; 5RVG; 5RVH; 5RVI; 5RVJ; 5RVK; 5RVL; 5RVM; 5RVN; 5RVO; 5RVP; 5RVQ; 5RVR; 5RVS; 5RVT; 5RVU; 5RVV; 5S18; 5S1A; 5S1C; 5S1E; 5S1G; 5S1I; 5S1K; 5S1M; 5S1O; 5S1Q; 5S1S; 5S1U; 5S1W; 5S1Y; 5S20; 5S22; 5S24; 5S26; 5S27; 5S28; 5S29; 5S2A; 5S2B; 5S2C; 5S2D; 5S2E; 5S2F; 5S2G; 5S2H; 5S2I; 5S2J; 5S2K; 5S2L; 5S2M; 5S2N; 5S2O; 5S2P; 5S2Q; 5S2R; 5S2S; 5S2T; 5S2U; 5S2V; 5S2W; 5S2X; 5S2Y; 5S2Z; 5S30; 5S31; 5S32; 5S33; 5S34; 5S35; 5S36; 5S37; 5S38; 5S39; 5S3A; 5S3B; 5S3C; 5S3D; 5S3E; 5S3F; 5S3G; 5S3H; 5S3I; 5S3J; 5S3K; 5S3L; 5S3M; 5S3N; 5S3O; 5S3P; 5S3Q; 5S3R; 5S3S; 5S3T; 5S3U; 5S3V; 5S3W; 5S3X; 5S3Y; 5S3Z; 5S40; 5S41; 5S42; 5S43; 5S44; 5S45; 5S46; 5S47; 5S48; 5S49; 5S4A; 5S4B; 5S4C; 5S4D; 5S4E; 5S4F; 5S4G; 5S4H; 5S4I; 5S4J; 5S4K; 5S6X; 5S6Y; 5S6Z; 5S70; 5S71; 5S72; 5S73; 5S74; 5SA4; 5SA5; 5SA6; 5SA7; 5SA8; 5SA9; 5SAA; 5SAB; 5SAC; 5SAD; 5SAE; 5SAF; 5SAG; 5SAH; 5SAI; 5SBF; 5SKW; 5SKX; 5SKY; 5SKZ; 5SL0; 5SL1; 5SL2; 5SL3; 5SL4; 5SL5; 5SL6; 5SL7; 5SL8; 5SL9; 5SLA; 5SLB; 5SLC; 5SLD; 5SLE; 5SLF; 5SLG; 5SLH; 5SLI; 5SLJ; 5SLK; 5SLL; 5SLM; 5SLN; 5SLO; 5SLP; 5SLQ; 5SLR; 5SLS; 5SLT; 5SLU; 5SLV; 5SLW; 5SLX; 5SLY; 5SLZ; 5SM0; 5SM1; 5SM2; 5SM3; 5SM4; 5SM5; 5SM6; 5SM7; 5SM8; 5SM9; 5SMA; 5SMB; 5SMC; 5SMD; 5SME; 5SMF; 5SMG; 5SMH; 5SMI; 5SMK; 6LU7; 6LZE; 6M03; 6M0K; 6M2N; 6M2Q; 6M71; 6VWW; 6VXS; 6W01; 6W02; 6W4B; 6W4H; 6W61; 6W63; 6W6Y; 6W75; 6W9C; 6W9Q; 6WC1; 6WCF; 6WEN; 6WEY; 6WIQ; 6WJT; 6WKQ; 6WKS; 6WLC; 6WNP; 6WOJ; 6WQ3; 6WQD; 6WQF; 6WRH; 6WRZ; 6WTC; 6WTJ; 6WTK; 6WTM; 6WTT; 6WUU; 6WVN; 6WX4; 6WXC; 6WXD; 6WZU; 6X1B; 6X4I; 6XA4; 6XA9; 6XAA; 6XB0; 6XB1; 6XB2; 6XBG; 6XBH; 6XBI; 6XCH; 6XDH; 6XFN; 6XG3; 6XHM; 6XHU; 6XIP; 6XKF; 6XKH; 6XKM; 6XMK; 6XOA; 6XQS; 6XQT; 6XQU; 6XR3; 6Y2E; 6Y2F; 6Y2G; 6Y84; 6YB7; 6YNQ; 6YVA; 6YVF; 6YWK; 6YWL; 6YWM; 6YYT; 6YZ1; 6Z2E; 6Z5T; 6Z6I; 6Z72; 6ZCT; 6ZLW; 6ZM7; 6ZME; 6ZMI; 6ZMO; 6ZMT; 6ZN5; 6ZOJ; 6ZOK; 6ZON; 6ZP4; 6ZPE; 6ZRT; 6ZRU; 6ZSL; 7A1U; 7ABU; 7ADW; 7AEG; 7AEH; 7AF0; 7AGA; 7AHA; 7AK4; 7AKU; 7ALH; 7ALI; 7AMJ; 7ANS; 7AOL; 7AP6; 7APH; 7AQE; 7AQI; 7AQJ; 7AR5; 7AR6; 7ARF; 7AU4; 7AVD; 7AWR; 7AWS; 7AWU; 7AWW; 7AX6; 7AXM; 7AXO; 7AY7; 7B2J; 7B2U; 7B3E; 7B5Z; 7B77; 7B83; 7BAJ; 7BAK; 7BAL; 7BB2; 7BE7; 7BF3; 7BF4; 7BF5; 7BF6; 7BFB; 7BGP; 7BIJ; 7BQ7; 7BQY; 7BRO; 7BRP; 7BTF; 7BUY; 7BV1; 7BV2; 7BWQ; 7BZF; 7C2I; 7C2J; 7C2K; 7C2Q; 7C2Y; 7C6S; 7C6U; 7C7P; 7C8B; 7C8R; 7C8T; 7C8U; 7CA8; 7CAM; 7CB7; 7CBT; 7CJD; 7CJM; 7CMD; 7COM; 7CUT; 7CUU; 7CWB; 7CWC; 7CX9; 7D1M; 7D1O; 7D7K; 7D7L; 7DDC; 7DG6; 7DIY; 7DVX; 7DVY; 7DW0; 7DW6; 7E18; 7E19; 7E5X; 7E6K; 7EQ4; 7JFQ; 7JHE; 7JIB; 7JKV; 7JME; 7JOY; 7JP0; 7JP1; 7JPE; 7JPY; 7JPZ; 7JQ0; 7JQ1; 7JQ2; 7JQ3; 7JQ4; 7JQ5; 7JQB; 7JQC; 7JR3; 7JR4; 7JST; 7JSU; 7JT0; 7JT7; 7JU7; 7JUN; 7JVZ; 7JW8; 7JYC; 7JYY; 7JZ0; 7K0E; 7K0F; 7K0R; 7K1L; 7K1O; 7K3N; 7K3T; 7K40; 7K5I; 7K6D; 7K6E; 7K7P; 7K9P; 7KAG; 7KEG; 7KEH; 7KF4; 7KFI; 7KG3; 7KHP; 7KOA; 7KPH; 7KQO; 7KQP; 7KQW; 7KR0; 7KR1; 7KRI; 7KVL; 7KVR; 7KX5; 7KXB; 7KYU; 7L0D; 7L10; 7L11; 7L12; 7L13; 7L14; 7L1F; 7L5D; 7L6R; 7L6T; 7L8I; 7L8J; 7LB7; 7LBN; 7LBR; 7LBS; 7LCO; 7LCS; 7LCT; 7LDL; 7LDX; 7LFE; 7LFP; 7LFZ; 7LG2; 7LG3; 7LG7; 7LGO; 7LHQ; 7LKD; 7LKE; 7LKR; 7LKS; 7LKT; 7LKU; 7LKV; 7LKW; 7LKX; 7LLF; 7LLZ; 7LMD; 7LME; 7LMF; 7LOS; 7LTJ; 7LTN; 7LW3; 7LW4; 7LYH; 7LYI; 7LZT; 7LZU; 7LZV; 7LZW; 7LZX; 7LZY; 7LZZ; 7M00; 7M01; 7M02; 7M03; 7M04; 7M2P; 7M8M; 7M8N; 7M8O; 7M8P; 7M8X; 7M8Y; 7M8Z; 7M90; 7M91; 7MBG; 7MBI; 7MC5; 7MC6; 7ME0; 7MGR; 7MGS; 7MHF; 7MHG; 7MHH; 7MHI; 7MHJ; 7MHK; 7MHL; 7MHM; 7MHN; 7MHO; 7MHP; 7MHQ; 7MLF; 7MLG; 7MNG; 7MPB; 7MRR; 7MSW; 7MSX; 7N06; 7N0B; 7N0C; 7N0D; 7N33; 7N3K; 7N44; 7N5Z; 7N6N; 7N7R; 7N7U; 7N7W; 7N7Y; 7N83; 7N89; 7N8C; 7NBR; 7NBS; 7NBT; 7NBY; 7NEO; 7NEV; 7NF5; 7NFV; 7NG3; 7NG6; 7NIO; 7NN0; 7NNG; 7NT4; 7NTS; 7O46; 7O7Y; 7O7Z; 7O80; 7O81; 7ORR; 7ORU; 7ORV; 7ORW; 7QBB; 7QGI; 7QIF; 7R2V; 7R7H; 7RB0; 7RB2; 7RBZ; 7RC0; 7RFR; 7RFS; 7RFU; 7RFW; 7RLS; 7RM2; 7RMB; 7RME; 7RMT; 7RMZ; 7RN0; 7RN1; 7RN4; 7RNH; 7RNK; 7RNW; 7RQG; 7S3K; 7S3S; 7S4B; 7S82; 7SI9; 7T42; 7T43; 7T44; 7T45; 7T46; 7T48; 7T49; 7T4A; 7T4B; 7T9W; 7TDU; 7TE0; 7TEH; 7TFR; 7THH; 7TI9; 7TJ2; 7TQ5; 7TQ6; 7TQV; 7TWF; 7TWG; 7TWH; 7TWI; 7TWJ; 7TWN; 7TWO; 7TWP; 7TWQ; 7TWR; 7TWS; 7TWT; 7TWV; 7TWW; 7TWX; 7TWY; 7TX0; 7TX1; 7TX3; 7TX4; 7TX5; 7ULT; 7VAH; 7WOH

1 entry

Accessory factor US11 (Vmw21)

RNB_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

2 entries

Protein UL35

Select_allDeselect_all
UL35_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
UL35_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Tegument protein UL35

5 entries

Polymerase cofactor VP35

Select_allDeselect_all
VP35_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus) reference strain

Polymerase cofactor VP35 (Ebola VP35) (eVP35)

VP35_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

Polymerase cofactor VP35 (Ebola VP35) (eVP35)

VP35_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP35_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
VP35_EBOSU
Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus)