Inhibition of host TBK1 by virus (kw:KW-1223)
Following activation of toll-like receptors by viral components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB.
Several viruses including herpesviruses or poxviruses interact directly with and inhibit TBK1 to prevent IRFs activation.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)50 entries grouped by protein
3 entries
Protein MGF 360-11L
3 entries
TBK1 inhibitor DP96R
7 entries
Non-structural protein 1 (Non-structural protein 1C)
6 entries
Non-structural protein 2 (NS2) (Non-structural protein 1B)
2 entries
Non-structural protein NS-S (NSs)
2 entries
IFN signaling evasion protein OPG029
13 entries
Phosphoprotein (Protein P) (Protein M1)
2 entries
Genome polyprotein
1 entry
Non-structural polyprotein pORF1
2 entries
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
1 entry
Accessory factor US11 (Vmw21)
2 entries
Protein UL35
1 entry
Structural protein A137R (Structural protein p11.5)
5 entries