Inhibition of host TBK1 by virus (kw:KW-1223)
Following activation of toll-like receptors by viral components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB.
Several viruses including herpesviruses or poxviruses interact directly with and inhibit TBK1 to prevent IRFs activation.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)50 entries grouped by strain
2 entries
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain
2 entries
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
2 entries
Human respiratory syncytial virus B (strain B1) reference strain
1 entry
Borna disease virus (strain V) (BDV) reference strain
1 entry
Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain
1 entry
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
1 entry
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
1 entry
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
1 entry
Monkeypox virus reference strain
1 entry
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
1 entry
SFTS phlebovirus (isolate SFTSV/Human/China/HB29/2010) (Severe fever with thrombocytopenia virus) reference strain
1 entry
Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain
1 entry
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain
1 entry
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
1 entry
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
1 entry
Zika virus (ZIKV) reference strain
2 entries
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
2 entries
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)
2 entries
Human respiratory syncytial virus
2 entries
Human respiratory syncytial virus A (strain A2)
2 entries
Human respiratory syncytial virus B (strain 18537)
2 entries
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)
1 entry
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
1 entry
Heartland virus (HTRV)
1 entry
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)
1 entry
Porcine epidemic diarrhea virus (strain CV777) (PEDV)
1 entry
Rabies virus (strain CVS-11) (RABV)
1 entry
Rabies virus (strain China/DRV) (RABV)
1 entry
Rabies virus (strain China/MRV) (RABV)
1 entry
Rabies virus (strain ERA) (RABV)
1 entry
Rabies virus (strain HEP-Flury) (RABV)
1 entry
Rabies virus (strain India) (RABV)
1 entry
Rabies virus (strain Nishigahara RCEH) (RABV)
1 entry
Rabies virus (strain PM) (RABV)
1 entry
Rabies virus (strain PM1503/AVO1) (RABV)
1 entry
Rabies virus (strain SAD B19) (RABV)
1 entry
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
1 entry
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
1 entry
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
1 entry
Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus)
1 entry