Inhibition of host TBK1 by virus

Following activation of toll-like receptors by viral components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB.

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Several viruses including herpesviruses or poxviruses interact directly with and inhibit TBK1 to prevent IRFs activation.

Inhibition of host TLR pathway Inhibition of host TBK1
Links Uniprot Keyword: KW-1223
GO ontology: GO:0039723
Virus -Herpes virus 1
(Herpesviridae, simplexvirus)

-Murine gammaherpesvirus 68 (MHV-4)
(Herpesviridae, rhadinovirus)

-Vaccinia virus
(Poxviridae, orthopoxvirus )

Matching UniProtKB/Swiss-Prot entries

24 entries grouped by strain (browse by keywords)

2 entries

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

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NS2_BRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_BRSVA Non-structural protein 1 (Non-structural protein 1C)

2 entries

Human respiratory syncytial virus A (strain A2) reference strain

Select_allDeselect_all
NS1_HRSVA Non-structural protein 1 (NS1) (Non-structural protein 1C)
NS2_HRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)

2 entries

Human respiratory syncytial virus B (strain B1) reference strain

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NS2_HRSVB Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_HRSVB Non-structural protein 1 (Non-structural protein 1C)

1 entry

Borna disease virus (strain V) (BDV) reference strain

PHOSP_BDVV Phosphoprotein (P protein) (p23) (p24)

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

RNB_HHV11 Accessory factor US11 (Vmw21)

1 entry

Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain

POLG_SVV1 Genome polyprotein [Cleaved into: Leader protein; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 ...

1 entry

Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

R1AB_SARS2 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

pdb 5R7Y; 5R7Z; 5R80; 5R81; 5R82; 5R83; 5R84; 5R8T; 5RE4; 5RE5; 5RE6; 5RE7; 5RE8; 5RE9; 5REA; 5REB; 5REC; 5RED; 5REE; 5REF; 5REG; 5REH; 5REI; 5REJ; 5REK; 5REL; 5REM; 5REN; 5REO; 5REP; 5RER; 5RES; 5RET; 5REU; 5REV; 5REW; 5REX; 5REY; 5REZ; 5RF0; 5RF1; 5RF2; 5RF3; 5RF4; 5RF5; 5RF6; 5RF7; 5RF8; 5RF9; 5RFA; 5RFB; 5RFC; 5RFD; 5RFE; 5RFF; 5RFG; 5RFH; 5RFI; 5RFJ; 5RFK; 5RFL; 5RFM; 5RFN; 5RFO; 5RFP; 5RFQ; 5RFR; 5RFS; 5RFT; 5RFU; 5RFV; 5RFW; 5RFX; 5RFY; 5RFZ; 5RG0; 5RG1; 5RG2; 5RG3; 5RGG; 5RGH; 5RGI; 5RGJ; 5RGK; 5RGL; 5RGM; 5RGN; 5RGO; 5RGP; 5RGQ; 5RGR; 5RGS; 5RGT; 5RGU; 5RGV; 5RGW; 5RGX; 5RGY; 5RGZ; 5RH0; 5RH1; 5RH2; 5RH3; 5RH4; 5RH5; 5RH6; 5RH7; 5RH8; 5RH9; 5RHA; 5RHB; 5RHC; 5RHD; 5RHE; 5RHF; 5RL6; 5RL7; 5RL8; 5RL9; 5RLB; 5RLC; 5RLD; 5RLE; 5RLF; 5RLG; 5RLH; 5RLI; 5RLJ; 5RLK; 5RLL; 5RLM; 5RLN; 5RLO; 5RLP; 5RLQ; 5RLR; 5RLS; 5RLT; 5RLU; 5RLV; 5RLW; 5RLY; 5RLZ; 5RM0; 5RM1; 5RM2; 5RM3; 5RM4; 5RM5; 5RM6; 5RM7; 5RM8; 5RM9; 5RMA; 5RMB; 5RMC; 5RMD; 5RME; 5RMF; 5RMG; 5RMH; 5RMI; 5RMJ; 5RMK; 5RML; 5RMM; 6LU7; 6LZE; 6M03; 6M0K; 6M2N; 6M2Q; 6M71; 6VWW; 6VXS; 6W01; 6W02; 6W4B; 6W4H; 6W61; 6W63; 6W6Y; 6W75; 6W9C; 6W9Q; 6WC1; 6WCF; 6WEN; 6WEY; 6WIQ; 6WJT; 6WKQ; 6WKS; 6WLC; 6WNP; 6WOJ; 6WQ3; 6WQD; 6WQF; 6WRH; 6WRZ; 6WTC; 6WTJ; 6WTK; 6WTM; 6WTT; 6WUU; 6WVN; 6WX4; 6WXC; 6WXD; 6WZU; 6X1B; 6X4I; 6XA4; 6XA9; 6XAA; 6XB0; 6XB1; 6XB2; 6XBG; 6XBH; 6XBI; 6XCH; 6XDH; 6XFN; 6XG3; 6XHM; 6XHU; 6XIP; 6XKF; 6XKH; 6XKM; 6XMK; 6XOA; 6XQS; 6XQT; 6XQU; 6XR3; 6Y2E; 6Y2F; 6Y2G; 6Y84; 6YB7; 6YNQ; 6YT8; 6YVA; 6YVF; 6YWK; 6YWL; 6YWM; 6YYT; 6YZ1; 6YZ6; 6Z2E; 6ZCT; 6ZLW; 6ZM7; 6ZME; 6ZMI; 6ZMO; 6ZMT; 6ZN5; 6ZOJ; 6ZOK; 6ZON; 6ZP4; 6ZPE; 6ZRT; 6ZRU; 6ZSL; 7AKU; 7BQ7; 7BQY; 7BRO; 7BRP; 7BTF; 7BUY; 7BV1; 7BV2; 7BZF; 7C2I; 7C2J; 7C2K; 7C2Q; 7C2Y; 7C6S; 7C6U; 7C7P; 7C8B; 7C8R; 7C8T; 7C8U; 7CBT; 7CJD; 7CJM; 7CMD; 7COM; 7CWB; 7CWC; 7CX9; 7D1M; 7D1O; 7JFQ; 7JHE; 7JIB; 7JKV; 7JME; 7JOY; 7JP1; 7JPE; 7JR3; 7JR4; 7JU7; 7JUN; 7JVZ; 7JYC; 7JYY; 7JZ0; 7K1L; 7K1O; 7K3N; 7K3T; 7K40; 7K5I; 7K6D; 7K6E; 7K7P; 7K9P; 7KAG; 7KFI; 7KFJ; 7KG3; 7KHP

1 entry

Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus) reference strain

VP35_EBOSU Polymerase cofactor VP35

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

C6_VACCW Protein C6

1 entry

Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

VP35_EBOZM Polymerase cofactor VP35 (Ebola VP35) (eVP35)

1 entry

Zika virus (ZIKV) reference strain

POLG_ZIKV Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

2 entries

Human respiratory syncytial virus A (strain Long)

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NS2_HRSVL Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_HRSVL Non-structural protein 1 (Non-structural protein 1C)

2 entries

Human respiratory syncytial virus B (strain 18537)

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NS1_HRSV1 Non-structural protein 1 (Non-structural protein 1C)
NS2_HRSV1 Non-structural protein 2 (NS2) (Non-structural protein 1B)

2 entries

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

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NS2_ORSVW Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_ORSVW Non-structural protein 1 (Non-structural protein 1C)

1 entry

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

NS1_HRSS2 Non-structural protein 1 (NS1) (Non-structural protein 1C)

1 entry

Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)

VP35_EBORE Polymerase cofactor VP35

1 entry

Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)

VP35_EBORR Polymerase cofactor VP35

1 entry

Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)

VP35_EBOZ5 Polymerase cofactor VP35 (Ebola VP35) (eVP35)