Sigmavirus (taxid:1308858)

Molecular biology

VIRION

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Enveloped, bullet shaped.

GENOME

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Negative-stranded RNA linear genome,about 12.6 kb in size. Encodes for 6 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

6 entries grouped by strain

6 entries

Drosophila melanogaster sigma virus (isolate Drosophila/USA/AP30/2005) (DMelSV) reference strain

Select_allDeselect_all
L_DMSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYCO_DMSVA Glycoprotein
NCAP_DMSVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PP3_DMSVA Protein PP3
MATRX_DMSVA Matrix protein
PHOSP_DMSVA Phosphoprotein (P protein)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Drosophila melanogaster sigma virus (isolate Drosophila/USA/AP30/2005) taxid:666363

Protein ModelArchive
Glycoprotein ma-jd-viral-07129
Matrix protein ma-jd-viral-11582
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15124
Phosphoprotein (P protein) ma-jd-viral-58560
Protein PP3 ma-jd-viral-42242

Drosophila obscura sigmavirus 10A taxid:666962

Protein ModelArchive
Glycoprotein ma-jd-viral-07063
Matrix protein ma-jd-viral-11608
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15104
Polymerase-associated protein ma-jd-viral-51430
Uncharacterized protein X ma-jd-viral-45775

Hubei dimarhabdovirus 1 taxid:2849739

Protein ModelArchive
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15147
Phosphoprotein ma-jd-viral-58265
Putative glycoprotein ma-jd-viral-07069
Putative matrix protein ma-jd-viral-11715

Hubei diptera virus 10 taxid:1922871

Protein ModelArchive
Matrix protein ma-jd-viral-11662
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15199
Phosphoprotein ma-jd-viral-53857
Putative X protein ma-jd-viral-38969
Putative glycoprotein ma-jd-viral-07106

Hubei diptera virus 9 taxid:1922889

Protein ModelArchive
Matrix protein ma-jd-viral-11659
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15213
Phosphoprotein ma-jd-viral-29069
Putative X protein ma-jd-viral-38967
Putative glycoprotein ma-jd-viral-07119

Shayang Fly Virus 2 taxid:1608066

Protein ModelArchive
Glycoprotein ma-jd-viral-07062
Matrix protein ma-jd-viral-11661
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15081
ORF2 ma-jd-viral-49493
X protein ma-jd-viral-38965

Wuhan Fly Virus 2 taxid:1608102

Protein ModelArchive
Glycoprotein ma-jd-viral-07085
Matrix protein ma-jd-viral-11664
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15156
ORF2 ma-jd-viral-49492
X protein ma-jd-viral-38968

Wuhan House Fly Virus 1 taxid:1608104

Protein ModelArchive
Glycoprotein ma-jd-viral-07089
Matrix protein ma-jd-viral-11658
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15128
Putative X protein ma-jd-viral-38966
Putative phosphoprotein ma-jd-viral-29518

Wuhan Louse Fly Virus 10 taxid:1608114

Protein ModelArchive
Glycoprotein ma-jd-viral-07082
Matrix protein ma-jd-viral-11581
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15143
Putative phosphoprotein ma-jd-viral-49369

Wuhan Louse Fly Virus 9 taxid:1608123

Protein ModelArchive
Glycoprotein ma-jd-viral-65404
Matrix protein ma-jd-viral-11580
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15091
Putative phosphoprotein ma-jd-viral-65825