Arenaviridae

VIRION

Enveloped, spherical. Diameter from 60 to 300 nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is about 7,5 kb and S segment 3,5 kb.
Encodes for four proteins.

GENE EXPRESSION

Both segments are ambisens. The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes a messager RNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped, probably by L protein during synthesis.

REPLICATION

CYTOPLASM

  1. Virus attaches to host receptors though GP glycoprotein and is endocytosed into vesicles in the host cell by apoptotic mimicry.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the Z protein under the plasma membrane and buds, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The Z protein plays a role in inhibition of antiviral signaling through RIG-I

Matching UniProtKB/Swiss-Prot entries

91 entries grouped by protein (browse by keywords)

All proteins are shown (view only 81 complete proteome entries)

27 entries

Pre-glycoprotein polyprotein GP complex (Pre-GP-C)

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GLYC_GOGV
Alethinophid 1 reptarenavirus (isolate AlRrV1/Boa/USA/BC/2009) (Golden Gate virus) reference strain

Glycoprotein

GLYC_LASSJ
Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
GLYC_LATVB
Latino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV) reference strain
GLYC_LYCVA
Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
GLYC_PIRVV
Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV) reference strain
GLYC_TACVF
Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
GLYC_TAMVU
Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV) reference strain
GLYC_ALLVP
Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
GLYC_BCNVU
Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
GLYC_CHAVB
Chapare mammarenavirus (isolate Human/Bolivia/810419/2003)
GLYC_CPXVB
Cupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
GLYC_GTOVV
Guanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
GLYC_IPPYV
Ippy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
GLYC_JUNIN
Junin mammarenavirus (JUNV) (Junn mammarenavirus)
GLYC_LASSG
Lassa virus (strain GA391) (LASV)
GLYC_LYCVW
Lymphocytic choriomeningitis virus (strain WE) (LCMV)
GLYC_MACHU
Machupo virus (MACV)
GLYC_MOBVC
Mobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
GLYC_MOPEI
Mopeia virus (MOPV)
GLYC_OLVVA
Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
GLYC_PARVP
Parana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran mammarenavirus)
GLYC_PIARV
Pichinde mammarenavirus (PICV) (Pichind mammarenavirus)
GLYC_SABVB
Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)
GLYC_TACV5
Tacaribe virus (strain V5) (TCRV)
GLYC_TACV7
Tacaribe virus (strain V7) (TCRV)
GLYC_TACVT
Tacaribe virus (strain TRVL 11598) (TCRV)
GLYC_WWAVU
Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV)

20 entries

RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) (Replicase) (Transcriptase)

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L_GOGV
Alethinophid 1 reptarenavirus (isolate AlRrV1/Boa/USA/BC/2009) (Golden Gate virus) reference strain

RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)

L_LASSJ
Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
L_LATVB
Latino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV) reference strain
L_LYCVA
Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
L_PIRVV
Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV) reference strain
L_TACVF
Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
L_TAMVU
Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV) reference strain
L_ALLVP
Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
L_BCNVU
Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
L_CHAVB
Chapare mammarenavirus (isolate Human/Bolivia/810419/2003)
L_CPXVB
Cupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
L_GTOVV
Guanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
L_IPPYV
Ippy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
L_JUNIN
Junin mammarenavirus (JUNV) (Junn mammarenavirus)
L_MACHU
Machupo virus (MACV)
L_MOBVC
Mobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
L_OLVVA
Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
L_PARVP
Parana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran mammarenavirus)
L_SABVB
Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)
L_WWAVU
Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV)

1 entry

Putative membrane protein

MEM_GOGV
Alethinophid 1 reptarenavirus (isolate AlRrV1/Boa/USA/BC/2009) (Golden Gate virus) reference strain

24 entries

Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

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NCAP_GOGV
Alethinophid 1 reptarenavirus (isolate AlRrV1/Boa/USA/BC/2009) (Golden Gate virus) reference strain

Nucleoprotein (Nucleocapsid protein) (Protein N)

NCAP_LASSJ
Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
NCAP_LATVB
Latino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV) reference strain
NCAP_LYCVA
Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
NCAP_PIRVV
Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV) reference strain
NCAP_TACVF
Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
NCAP_ALLVP
Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
NCAP_BCNVU
Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
NCAP_CHAVB
Chapare mammarenavirus (isolate Human/Bolivia/810419/2003)
NCAP_CPXVB
Cupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
NCAP_GTOVV
Guanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
NCAP_IPPYV
Ippy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
NCAP_JUNIN
Junin mammarenavirus (JUNV) (Junn mammarenavirus)
NCAP_LASSG
Lassa virus (strain GA391) (LASV)
NCAP_LYCVW
Lymphocytic choriomeningitis virus (strain WE) (LCMV)
NCAP_MACHU
Machupo virus (MACV)
NCAP_MOBVC
Mobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
NCAP_MOPEI
Mopeia virus (MOPV)
NCAP_OLVVA
Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
NCAP_PARVP
Parana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran mammarenavirus)
NCAP_PIARV
Pichinde mammarenavirus (PICV) (Pichind mammarenavirus)
NCAP_SABVB
Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)
NCAP_TAMVU
Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV)
NCAP_WWAVU
Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV)

19 entries

RING finger protein Z (Protein Z) (Zinc-binding protein)

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Z_LASSJ
Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
Z_LATVB
Latino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV) reference strain
Z_LYCVA
Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
Z_PIRVV
Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV) reference strain
Z_TACVF
Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
Z_TAMVU
Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV) reference strain
Z_ALLVP
Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
Z_BCNVU
Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
Z_CHAVB
Chapare mammarenavirus (isolate Human/Bolivia/810419/2003)
Z_CPXVB
Cupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
Z_GTOVV
Guanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
Z_IPPYV
Ippy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
Z_JUNIN
Junin mammarenavirus (JUNV) (Junn mammarenavirus)
Z_MACHU
Machupo virus (MACV)
Z_MOBVC
Mobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
Z_OLVVA
Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
Z_PARVP
Parana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran mammarenavirus)
Z_SABVB
Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)
Z_WWAVU
Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV)