Arenaviridae

VIRION

Enveloped, spherical. Diameter from 60 to 300 nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is about 7,5 kb and S segment 3,5 kb.
Encodes for four proteins.

GENE EXPRESSION

Both segments are ambisens. The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes a messager RNA. Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped, probably by L protein during synthesis.

REPLICATION

CYTOPLASM

  1. Virus attaches to host receptors though GP glycoprotein and is endocytosed into vesicles in the host cell by apoptotic mimicry.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the Z protein under the plasma membrane and buds, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The Z protein plays a role in inhibition of antiviral signaling through RIG-I

Matching UniProtKB/Swiss-Prot entries

91 entries grouped by strain (browse by keywords)

4 entries

Alethinophid 1 reptarenavirus (isolate AlRrV1/Boa/USA/BC/2009) (Golden Gate virus) reference strain

Select_allDeselect_all
L_GOGV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_GOGV Nucleoprotein (Nucleocapsid protein) (Protein N)
MEM_GOGV Putative membrane protein
GLYC_GOGV Glycoprotein

4 entries

Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV) reference strain

Select_allDeselect_all
GLYC_BCNVU Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
NCAP_BCNVU Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_BCNVU RING finger protein Z (Protein Z) (Zinc-binding protein)
L_BCNVU RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...

4 entries

Guanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV) reference strain

Select_allDeselect_all
Z_GTOVV RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_GTOVV Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
L_GTOVV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_GTOVV Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain

Select_allDeselect_all
Z_LASSJ RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_LASSJ Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
L_LASSJ RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_LASSJ Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Latino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV) reference strain

Select_allDeselect_all
NCAP_LATVB Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_LATVB RING finger protein Z (Protein Z) (Zinc-binding protein)
L_LATVB RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_LATVB Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain

Select_allDeselect_all
Z_LYCVA RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_LYCVA Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
L_LYCVA RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_LYCVA Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV) reference strain

Select_allDeselect_all
Z_OLVVA RING finger protein Z (Protein Z) (Zinc-binding protein)
GLYC_OLVVA Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_OLVVA RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
NCAP_OLVVA Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

4 entries

Parana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran mammarenavirus) reference strain

Select_allDeselect_all
Z_PARVP RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_PARVP Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
L_PARVP RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_PARVP Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV) reference strain

Select_allDeselect_all
Z_PIRVV RING finger protein Z (Protein Z) (Zinc-binding protein)
L_PIRVV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
NCAP_PIRVV Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
GLYC_PIRVV Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain

Select_allDeselect_all
L_TACVF RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
NCAP_TACVF Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_TACVF RING finger protein Z (Protein Z) (Zinc-binding protein)
GLYC_TACVF Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

3 entries

Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV) reference strain

Select_allDeselect_all
Z_TAMVU RING finger protein Z (Protein Z) (Zinc-binding protein)
L_TAMVU RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_TAMVU Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV) reference strain

Select_allDeselect_all
NCAP_WWAVU Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_WWAVU RING finger protein Z (Protein Z) (Zinc-binding protein)
L_WWAVU RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_WWAVU Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)

Select_allDeselect_all
Z_ALLVP RING finger protein Z (Protein Z) (Zinc-binding protein)
L_ALLVP RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
NCAP_ALLVP Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
GLYC_ALLVP Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Chapare mammarenavirus (isolate Human/Bolivia/810419/2003)

Select_allDeselect_all
Z_CHAVB RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_CHAVB Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
L_CHAVB RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_CHAVB Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Cupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)

Select_allDeselect_all
Z_CPXVB RING finger protein Z (Protein Z) (Zinc-binding protein)
L_CPXVB RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
NCAP_CPXVB Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
GLYC_CPXVB Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Ippy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)

Select_allDeselect_all
GLYC_IPPYV Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
L_IPPYV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
Z_IPPYV RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_IPPYV Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

4 entries

Junin mammarenavirus (JUNV) (Junn mammarenavirus)

Select_allDeselect_all
NCAP_JUNIN Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
Z_JUNIN RING finger protein Z (Protein Z) (Zinc-binding protein)
L_JUNIN RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_JUNIN Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Machupo virus (MACV)

Select_allDeselect_all
Z_MACHU RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_MACHU Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
L_MACHU RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_MACHU Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Mobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)

Select_allDeselect_all
Z_MOBVC RING finger protein Z (Protein Z) (Zinc-binding protein)
NCAP_MOBVC Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
L_MOBVC RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
GLYC_MOBVC Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

4 entries

Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)

Select_allDeselect_all
NCAP_SABVB Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
L_SABVB RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (EC 3.1.-.-) (Large structural protein) ...
Z_SABVB RING finger protein Z (Protein Z) (Zinc-binding protein)
GLYC_SABVB Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

1 entry

Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV)

NCAP_TAMVU Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

2 entries

Lassa virus (strain GA391) (LASV)

Select_allDeselect_all
NCAP_LASSG Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
GLYC_LASSG Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

2 entries

Lymphocytic choriomeningitis virus (strain WE) (LCMV)

Select_allDeselect_all
NCAP_LYCVW Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)
GLYC_LYCVW Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

2 entries

Mopeia virus (MOPV)

Select_allDeselect_all
GLYC_MOPEI Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
NCAP_MOPEI Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

2 entries

Pichinde mammarenavirus (PICV) (Pichind mammarenavirus)

Select_allDeselect_all
GLYC_PIARV Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...
NCAP_PIARV Nucleoprotein (EC 3.1.13.-) (Nucleocapsid protein) (Protein N)

1 entry

Tacaribe virus (strain TRVL 11598) (TCRV)

GLYC_TACVT Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

1 entry

Tacaribe virus (strain V5) (TCRV)

GLYC_TACV5 Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...

1 entry

Tacaribe virus (strain V7) (TCRV)

GLYC_TACV7 Pre-glycoprotein polyprotein GP complex (Pre-GP-C) [Cleaved into: Stable signal peptide (SSP); ...