As part of the Gag polyprotein, facilitates virus ESCRT-dependent budding through two distinct late assembly domains (L-domains) and allows incorporation
of Vpr into virus particles .
INTERACTIONS
Interacts with host Tsg101 and ALIX. Interacts with the viral protein Vpr (when phosphorylated).
SUBCELLULAR LOCATION
Virion
Cytoplasm
TIMING OF EXPRESSION
Late
Wrapping up the bad news: HIV assembly and release Bo Meng, Andrew Ml Lever Retrovirology 2013; 10: 5
The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions Ayumi Kudoh, Shoukichi Takahama, Tatsuya Sawasaki, Hirotaka Ode, Masaru Yokoyama, Akiko Okayama, Akiyo Ishikawa, Kei Miyakawa, Satoko Matsunaga, Hirokazu Kimura, Wataru Sugiura, Hironori Sato, Hisashi Hirano, Shigeo Ohno, Naoki Yamamoto, Akihide Ryo Retrovirology 2014; 11: 9