HIV-1 VPR protein
| Plays an essential role in the entry of the viral cDNA genome into the host nucleus during infection of quiescent cells . During virus entry, Vpr colocalizes with the capsid until the latter reaches the nucleus membrane |
During virus exit, induces host cell G2 arrest possibly through degradation of host repair proteins, stopping cell division in G2-M damage checkpoint.
The lymphocytes stopped in G2-M eventually go into apoptosis , which is thought to be the main cause of AIDS disease.
|Host UNG , VPRBP (DCAF1)|
|TIMING OF EXPRESSION|