Potyvirus

VIRION

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Non-enveloped, flexuous, filamentous, of 720-850 nm long and 12-15 nm in diameter. Symmetry helical. Presence of characteristic inclusion bodies within infected plant cells.

GENOME

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Monopartite, linear, ssRNA(+) genome of 10 kb in size. 3' terminus has a poly (A) tract. 5' terminus has a genome-linked protein (VPg).

GENE EXPRESSION

Virion RNA is infectious and serves as both the genome and viral messenger RNA. The genomic RNA is translated into polyproteins by VPG-EIF4 Viral initiation of translation. The polyproteins are then processed into functional products by the action of three viral-encoded proteinases. P3N-PIPO is expressed by polymerase slippage mechanism from the P3 ORF and probably acts as a movement protein .

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated to produce a polyprotein which is processed by viral proteases into the RdRp protein and structural proteins.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Virus assembly in the cytoplasm.
  7. Viral movement protein P3N-PIPO probably mediates virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Potyviruses HC-PRO functions as a suppressor of RNA silencing .

Suppression of other plant defenses

VPg is a potent inhibitor of PAP depurination of RNA, thereby suppressing one of the plant defense mechanisms .

Matching UniProtKB/Swiss-Prot entries

49 entries grouped by strain (browse by keywords)

2 entries

Potato virus Y (strain N) (PVY) reference strain

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POLG_PVYN Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_PVYN P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Bean common mosaic necrosis virus (strain NL-3) (BCMNV) (Bean common mosaic virus serotype A (strain NL-3))

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MVP_BCMNN P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_BCMNN Genome polyprotein [Cleaved into: P1 proteinase (N-terminal protein); Helper component proteinase ...

2 entries

Bean yellow mosaic virus

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MVP_BYMV P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_BYMV Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...

2 entries

Beet mosaic virus (BtMV)

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MVP_BTMV P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_BTMV Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...

2 entries

Lettuce mosaic virus (strain 0 / isolate French) (LMV)

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POLG_LMV0 Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_LMV0 P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Lettuce mosaic virus (strain E) (LMV)

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POLG_LMVE Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_LMVE P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Papaya ringspot virus (strain P / mutant HA)

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POLG_PRSVH Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_PRSVH P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Pea seed-borne mosaic virus (strain DPD1)

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MVP_PSBMV P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_PSBMV Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...

2 entries

Peanut mottle virus (strain M)

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MVP_PEMVM P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_PEMVM Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...

2 entries

Pepper mottle virus (isolate California) (PeMV) (PepMoV C)

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POLG_PEMVC Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_PEMVC P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Plum pox potyvirus (isolate NAT) (PPV)

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POLG_PPVNA Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_PPVNA P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Plum pox potyvirus (strain D) (PPV)

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POLG_PPVD Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_PPVD P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Plum pox potyvirus (strain SK 68) (PPV)

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MVP_PPVSK P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_PPVSK Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...

2 entries

Potato virus A (PVA)

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POLG_PVMA Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_PVMA P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Potato virus Y (strain Hungarian) (PVY)

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MVP_PVYHU P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_PVYHU Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...

2 entries

Soybean mosaic virus (strain G2) (SMV)

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POLG_SBMVG Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_SBMVG P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Soybean mosaic virus (strain N) (SMV)

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POLG_SBMVN Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_SBMVN P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Tobacco etch virus (TEV)

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POLG_TEV Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_TEV P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Tobacco vein mottling virus (TVMV)

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MVP_TVMV P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_TVMV Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...

2 entries

Turnip mosaic virus (strain Japanese) (TuMV)

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POLG_TUMVJ Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_TUMVJ P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Turnip mosaic virus (strain Quebec) (TuMV)

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POLG_TUMVQ Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_TUMVQ P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Zucchini yellow mosaic virus (strain California) (ZYMV)

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POLG_ZYMVC Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...
MVP_ZYMVC P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...

2 entries

Zucchini yellow mosaic virus (strain Reunion Island) (ZYMV)

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MVP_ZYMVR P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_ZYMVR Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...

2 entries

Zucchini yellow mosaic virus (strain Singapore) (ZYMV)

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MVP_ZYMVS P3N-PIPO polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper ...
POLG_ZYMVS Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...

1 entry

Plum pox potyvirus (strain Rankovic) (PPV)

POLG_PPVRA Genome polyprotein [Cleaved into: P1 proteinase (EC 3.4.-.-) (N-terminal protein); Helper component ...