Seadornavirus (taxid:208294)

Seadornavirus is a genus of dsRNA viruses in the Reoviridae family that infect humans and cattle and are transmitted by mosquitoes. Banna virus (BAV) infections in humans are associated with encephalitis.



Non enveloped, icosahedral, non-turreted virion with a triple capsid structure, about 60-70 nm in diameter. The intermediate capsid has a T=13 icosahedral symmetry, the inner capsid a T=2* icosahedral symmetry.



Segmented linear dsRNA genome. Contains 12 segments encoding 12 proteins. Segments size range from 862 to 3747 bp, genome total size is about 21 kb (BAV).


The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase synthesizes a capped mRNA from each dsRNA segment. This capped mRNA is translocated to the cell cytoplasm where it is translated.




  1. Attachment to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

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12 entries grouped by strain

12 entries

Banna virus (strain Indonesia/JKT-6423/1980) (BAV) reference strain

VP3_BAVJK Viral guanylyltransferase VP3 (Virion protein 3) (VP3) [Includes: mRNA guanylyltransferase (EC ...
RDRP_BAVJK RNA-directed RNA polymerase VP1 (EC (Virion protein 1) (VP1)
SPIKE_BAVJK Spike protein VP9 (Virion protein 9) (VP9)
VP2_BAVJK Major inner capsid protein VP2
VP8_BAVJK Intermediate capsid protein VP8 (Virion protein 8) (VP8)
VP10_BAVJK Structural protein VP10
NS4_BAVJK Non-structural protein 4 (NS4) (VP11)
NS2_BAVJK Non-structural protein 2 (NS2) (VP6)
NS1_BAVJK Non-structural protein 1 (NS1)
VP4_BAVJK Outer capsid protein VP4
NS5_BAVJK Non-structural protein 5 (NS5)
NS3_BAVJK Non-structural protein 3 (NS3)