Non-enveloped, 30 nm in diameter, pseudo T=3 icosahedral capsid.
Linear ssRNA(+) genome of about 12 kb. The 5' terminus has a genome-linked protein (VPg). A poly (A) tract is present at the 3'-end of the Waikavirus genus.
The virion RNA is infectious and serves as both the genome and viral messenger RNA. The genome single (or major) ORF is translated into a polyprotein which is subsequently processed by virus-encoded proteases into functional products. There may be also be two small ORFs near the 3'-end.
- RNA-dependent RNA polymerase [RdRp]
- VPG-type capping [VPg]
- NTPase-helicase [Hel]
- Polyprotein major protease (Peptidase C3) [Pro]
- Virus penetrates into the cell.
- Uncoating, and release of the viral genomic RNA into the cytoplasm.
- Synthesis and proteolytic cleavage of the viral polyprotein.
- Replication occurs in viral factories made of membrane vesicles derived from the ER. A dsRNA genome is synthesized from the genomic ssRNA(+).
- The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
- Assembly of new virus particles.