Inhibition of host tetherin by virus

Tetherin is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses, including human immunodeficiency virus type 1 (HIV-1), HIV-2, other retroviruses, Lassa virus-like particles (VLPs), Marburg and Ebola VLPs.
Tetherin may also act as an innate immune sensor of viral infections that activates NF-kappaB to induce an inflammatory response.

Several viruses manage to circumvent the antiviral activity of tetherin. The Vpu protein form HIV-1 bridges tetherin to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, inducing its ubiquitination and subsequent proteasomal degradation. HIV-2 instead downregulates cell surface expression of tetherin, restricting it to the trans-Golgi network via direct interaction with the viral glycoprotein.

Matching UniProtKB/Swiss-Prot entries

61 entries grouped by strain (browse by keywords)

2 entries

Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain

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SPIKE_SARS Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...
NS7A_SARS ORF7a protein (Accessory protein 7a) (Protein U122) (Protein X4)

2 entries

Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

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SPIKE_SARS2 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike ...

pdb 6LVN; 6LXT; 6LZG; 6M0J; 6M17; 6M1V; 6VSB; 6VW1; 6VXX; 6VYB; 6W41; 6WPS; 6WPT; 6X29; 6X2A; 6X2B; 6X2C; 6X6P; 6X79; 6XC2; 6XC3; 6XC4; 6XC7; 6XCM; 6XCN; 6XDG; 6XE1; 6XEY; 6XF5; 6XF6; 6XKL; 6XKP; 6XKQ; 6XLU; 6XM0; 6XM3; 6XM4; 6XM5; 6XR8; 6XRA; 6XS6; 6YLA; 6YM0; 6YOR; 6YZ5; 6YZ7; 6Z2M; 6Z43; 6Z97; 6ZB4; 6ZB5; 6ZBP; 6ZCZ; 6ZDG; 6ZDH; 6ZER; 6ZFO; 6ZGE; 6ZGG; 6ZGI; 6ZH9; 6ZHD; 6ZLR; 6ZOW; 6ZOX; 6ZOY; 6ZOZ; 6ZP0; 6ZP1; 6ZP2; 6ZP5; 6ZP7; 6ZWV; 6ZXN; 7A25; 7A29; 7A4N; 7A5R; 7A5S; 7A91; 7A92; 7A93; 7A94; 7A95; 7A96; 7A97; 7A98; 7AD1; 7B17; 7BEH; 7BEI; 7BEJ; 7BEK; 7BEL; 7BEM; 7BEN; 7BEO; 7BEP; 7BWJ; 7BYR; 7BZ5; 7C01; 7C2L; 7C8D; 7C8J; 7C8V; 7C8W; 7CAB; 7CAC; 7CAH; 7CAI; 7CAK; 7CAN; 7CDI; 7CDJ; 7CH4; 7CH5; 7CHB; 7CHC; 7CHE; 7CHF; 7CHH; 7CJF; 7CM4; 7CN9; 7CT5; 7CWL; 7CWM; 7CWN; 7CWO; 7CWS; 7CWU; 7D2Z; 7D30; 7DCC; 7DCX; 7DD2; 7DD8; 7DDD; 7DDN; 7DF3; 7DF4; 7DK3; 7DK4; 7DK5; 7DK6; 7DK7; 7DMU; 7DPM; 7JJC; 7JJI; 7JJJ; 7JMO; 7JMP; 7JMW; 7JV2; 7JV4; 7JV6; 7JVA; 7JVB; 7JVC; 7JW0; 7JWB; 7JWY; 7JX3; 7JZL; 7JZM; 7JZN; 7JZU; 7K43; 7K45; 7K4N; 7K8M; 7K8S; 7K8T; 7K8U; 7K8V; 7K8W; 7K8X; 7K8Y; 7K8Z; 7K90; 7K9Z; 7KDG; 7KDH; 7KDI; 7KDJ; 7KDK; 7KDL; 7KE4; 7KE6; 7KE7; 7KE8; 7KE9; 7KEA; 7KEB; 7KEC; 7KGJ; 7KGK; 7KJ2; 7KJ3; 7KJ4; 7KJ5; 7KKK; 7KKL; 7KL9; 7KLG; 7KLH; 7KLW; 7KMB; 7KMG; 7KMH; 7KMI; 7KMK; 7KML; 7KMS; 7KMZ; 7KN5; 7KN6; 7KN7; 7KNB; 7KNE; 7KNH; 7KNI; 7KS9; 7KSG; 7KXJ; 7KXK; 7KZB; 7L02; 7L06; 7L09; 7L0N; 7L2C; 7L3N; 7L5B; 7L7F; 7L7K; 7LCN; 7LD1; 7LOP; 7ND3; 7ND4; 7ND5; 7ND6; 7ND7; 7ND8; 7ND9; 7NDA; 7NDB; 7NDC; 7NDD; 7NEH

NS7A_SARS2 ORF7a protein (ORF7a) (Accessory protein 7a) (Protein U122) (Protein X4)

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

VPU_HV1MA Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) reference strain

VPU_HV1A2 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain

VPU_HV1B1 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain

VPU_HV1BR Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

VPU_HV1H2 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1) reference strain

VPU_HV1RH Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1) reference strain

VPU_HV1Y2 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1) reference strain

VPU_HV1B9 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1) reference strain

VPU_HV192 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain

VPU_HV1ET Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain

VPU_HV1EL Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1) reference strain

VPU_HV193 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain

VPU_HV190 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1) reference strain

VPU_HV1YB Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain

VPU_HV1YF Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain

VPU_HV1AN Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1) reference strain

VPU_HV1MV Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) reference strain

ENV_HV2BE Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2) reference strain

ENV_HV2RO Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2) reference strain

ENV_HV2UC Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

VPU_SIVEK Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

VPU_SIVMB Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus) reference strain

VGP_EBOSU Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]

1 entry

Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

VGP_EBOZM Envelope glycoprotein (GP1,2) (GP) [Cleaved into: Shed GP (GP1,2-delta); GP1; GP2]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)

VPU_HV1B8 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)

VPU_HV1BN Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)

VPU_HV1C4 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

VPU_HV1H3 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JH32) (HIV-1)

VPU_HV1J3 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)

VPU_HV1JR Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)

VPU_HV1LW Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1)

VPU_HV1MN Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)

VPU_HV1SC Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)

VPU_HV1S1 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)

VPU_HV1ND Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)

VPU_HV1Z2 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1)

VPU_HV1VI Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 1 group M subtype U (isolate Z3) (HIV-1)

VPU_HV1Z3 Protein Vpu (U ORF protein) (Viral protein U)

1 entry

Human immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2)

ENV_HV2CA Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2)

ENV_HV2D1 Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)

ENV_HV2G1 Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2)

ENV_HV2KR Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2)

ENV_HV2NZ Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2)

ENV_HV2SB Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2)

ENV_HV2ST Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ST/24.1C#2) (HIV-2)

ENV_HV2S2 Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2)

ENV_HV2D2 Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Human immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2)

ENV_HV2EH Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) ...

1 entry

Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)

VGP_EBORE Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]

1 entry

Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)

VGP_EBORR Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]

1 entry

Reston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)

VGP_EBORS Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]

1 entry

Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)

VGP_EBOSB Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]

1 entry

Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus)

VGP_EBOSM Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]

1 entry

Tai Forest ebolavirus (strain Cote d'Ivoire-94) (TAFV) (Cote d'Ivoire Ebola virus)

VGP_TAFVC Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]

1 entry

Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus)

VGP_EBOEC Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]

1 entry

Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)

VGP_EBOG4 Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]

1 entry

Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)

VGP_EBOZ5 Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]