Inhibition of host tetherin by virus (kw:KW-1084)
Tetherin is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses, including human immunodeficiency
virus type 1 (HIV-1), HIV-2, other retroviruses, Lassa virus-like particles
(VLPs), Marburg and Ebola VLPs.
Tetherin may also act as an innate immune sensor of viral infections that activates NF-kappaB to induce an inflammatory response
.
Several viruses manage to circumvent the antiviral activity of tetherin. The Vpu protein form HIV-1 bridges tetherin to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, inducing its ubiquitination and subsequent proteasomal degradation. HIV-2 instead downregulates cell surface expression of tetherin, restricting it to the trans-Golgi network via direct interaction with the viral glycoprotein.
Carole Bampi, Lara Rasga, Laurent Roux
J. Gen. Virol. June 2013; 94: 1211?1219
Mandana Mansouri, Kasinath Viswanathan, Janet L. Douglas, Jennie Hines, Jean Gustin, Ashlee V. Moses, Klaus Fr?h
J. Virol. October 2009; 83: 9672?9681
Dominik Hotter, Daniel Sauter, Frank Kirchhoff
J. Mol. Biol. December 13, 2013; 425: 4956?4964
Philip H. Jones, Martina Maric, Marisa N. Madison, Wendy Maury, Richard J. Roller, Okeoma Okeoma
Virology March 30, 2013; 438: 37?49
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