Gammaretrovirus

VIRION

Enveloped, spherical to pleomorphic in shape, 80-100 nm in diameter.

GENOME

Monopartite, linear, dimeric, ssRNA(+) genome of about 8.3 kb, with a 5'-cap and a 3’poly-A tail. There are two long terminal repeats (LTRs) of about 600nt long at the 5' and 3' ends. The LTRs contain the U3, R, and U5 regions. There are also a primer binding site (PBS) at the 5’end and a polypurine tract (PPT) at the 3’end.

GENE EXPRESSION

The integrated provirus utilizes the promoter elements in the 5’LTR to drive transcription. This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag, and gag-(pro)pol (suppression of termination of the gag termination codon). The spliced mRNA encodes env that is cleaved into SU and TM envelope proteins. Glyco-GAG is translated by noncanonical initiation of translation .

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors through the SU glycoprotein. TM glycoprotein mediates fusion with cell membrane.
  2. Internalization and partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA when the nuclear membrane is disassembled at mitosis.
  5. Viral dsDNA is covalently and randomly integrated into the cell’s genome by the viral integrase (=provirus).
  6. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  7. Nuclear export of the incompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Matching UniProtKB/Swiss-Prot entries

114 entries grouped by strain (browse by keywords)

All proteins are shown (view only 50 complete proteome entries)

3 entries

Moloney murine leukemia virus (isolate Shinnick) (MoMLV) reference strain

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ENV_MLVMS Envelope glycoprotein (Pr80env) (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein ...
POL_MLVMS Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
GAG_MLVMS Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Xenotropic MuLV-related virus (isolate VP62) (XMRV) reference strain

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ENV_XMRV6 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein ...
POL_XMRV6 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
GAG_XMRV6 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

5 entries

Feline leukemia virus

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MYC_FLV Viral myc transforming protein (v-Myc)
GGAG_FLV Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
POL_FLV Gag-Pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...
GAG_FLV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
TCB_FLV Viral T-cell receptor beta chain-like T17T-22

4 entries

AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)

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ENV_MLVAV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GGAG_MLVAV Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
POL_MLVAV Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
GAG_MLVAV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

4 entries

Cas-Br-E murine leukemia virus

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ENV_MLVCB Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GGAG_MLVCB Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
POL_MLVCB Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...
GAG_MLVCB Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

4 entries

Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)

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ENV_FSVGA Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
FES_FSVGA Tyrosine-protein kinase transforming protein Fes (EC 2.7.10.2)
GGAG_FSVGA Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
GAG_FSVGA Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

4 entries

Friend murine leukemia virus (isolate 57) (FrMLV)

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ENV_MLVF5 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GGAG_MLVF5 Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
POL_MLVF5 Gag-Pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...
GAG_MLVF5 Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...

4 entries

Friend murine leukemia virus (isolate FB29) (FrMLV)

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ENV_MLVFF Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GGAG_MLVFF Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
POL_MLVFF Gag-Pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...
GAG_MLVFF Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...

4 entries

Friend murine leukemia virus (isolate PVC-211) (FrMLV)

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ENV_MLVFP Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
GGAG_MLVFP Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
POL_MLVFP Gag-Pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...
GAG_MLVFP Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...

3 entries

Abelson murine leukemia virus

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ABL_MLVAB Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl)
GAG_MLVAB Gag polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12; Capsid ...
V18K_MLVAB 18 kDa protein

3 entries

Baboon endogenous virus (strain M7)

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ENV_BAEVM Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
POL_BAEVM Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
GAG_BAEVM Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Feline sarcoma virus (strain McDonough)

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KFMS_FSVMD Tyrosine-protein kinase transforming protein fms (EC 2.7.10.1)
GGAG_FSVMD Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
GAG_FSVMD Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Feline sarcoma virus (strain Snyder-Theilen)

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FES_FSVST Tyrosine-protein kinase transforming protein Fes (EC 2.7.10.2)
GGAG_FSVST Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)
GAG_FSVST Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Gibbon ape leukemia virus (GALV)

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ENV_GALV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
POL_GALV Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
GAG_GALV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Koala retrovirus (KoRV)

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ENV_KORV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...
POL_KORV Gag-Pol polyprotein (Pr125Pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein ...
GAG_KORV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Moloney murine sarcoma virus (MoMSV)

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MOS_MSVMO Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)
GAG_MSVMO Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
RASH_MSVMO GTPase HRas (Transforming protein p21/H-Ras)

3 entries

Radiation murine leukemia virus

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ENV_MLVRD Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 76) ...
POL_MLVRD Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
GAG_MLVRD Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)

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POL_WMSV Gag-Pol polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); ...
TSIS_WMSV PDGF-related-transforming protein sis (p28sis)
GAG_WMSV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Xenotropic MuLV-related virus (isolate VP35) (XMRV)

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ENV_XMRV3 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein ...
POL_XMRV3 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
GAG_XMRV3 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

3 entries

Xenotropic MuLV-related virus (isolate VP42) (XMRV)

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ENV_XMRV4 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein ...
GAG_XMRV4 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
POL_XMRV4 Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Avian reticuloendotheliosis virus

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REL_AVIRE Transforming protein rel polyprotein (p58 V-rel) [Cleaved into: Env polyprotein N-terminal; ...
ENV_AVIRE Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 73) ...

2 entries

FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)

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FOSX_MSVFR Transforming protein v-Fos/v-Fox
GAG_MSVFR Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Feline sarcoma virus (strain Gardner-Rasheed)

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FGR_FSVGR Tyrosine-protein kinase transforming protein Fgr (EC 2.7.10.2)
GAG_FSVGR Core protein p15

2 entries

Feline sarcoma virus (strain Hardy-Zuckerman 4)

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KIT_FSVHZ Tyrosine-protein kinase transforming protein kit (EC 2.7.10.1)
GGAG_FSVHZ Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)

2 entries

Friend spleen focus-forming virus (isolate 502) (FSFFV)

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ENV_FRSF5 Glycoprotein 55 (gp55)
GAG_FRSF5 Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Hortulanus murine leukemia virus (HoMuLV) (Mus hortulanus virus)

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GAG_MLVHO Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...
ENV_MLVHO Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 76) ...

2 entries

Moloney murine sarcoma virus (strain ts110) (MoMSV)

Select_allDeselect_all
MOS_MSVMT Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)
GAG_MSVMT Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

2 entries

Murine leukemia virus (strain BM5 eco)

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POL_MLVBM Gag-pol polyprotein [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 (pp12); Capsid ...
GAG_MLVBM Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

AKT8 murine leukemia virus

AKT_MLVAT AKT kinase-transforming protein (EC 2.7.11.1)

1 entry

Avian spleen necrosis virus

ENV_AVISN Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 73) ...

1 entry

Cas-NS-1 murine leukemia virus

CBL_MLVCN Transforming protein cbl

1 entry

Duplan murine leukemia virus

GAG_MLVDU Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

FBJ murine osteosarcoma virus (FBJ-MSV) (Finkel-Biskis-Jinkins murine osteosarcoma virus)

FOS_MSVFB p55-v-Fos-transforming protein

1 entry

Feline endogenous virus ECE1

ENV_FENV1 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus (isolate CFE-6)

ENV_FLVC6 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus (strain A/Glasgow-1)

ENV_FLVGL Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus (strain B/lambda-B1)

ENV_FLVLB Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus (strain C/Sarma)

ENV_FLVSA Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Feline leukemia virus FTT

MYC_FLVTT Viral myc transforming protein (v-Myc)

1 entry

Feline sarcoma virus (strain Hardy-Zuckerman 2)

ABL_FSVHY Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl)

1 entry

Feline sarcoma virus (strain SM) (Sm-FeSV)

ENV_FSVSM Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Friend spleen focus-forming virus (strain BB6) (FSFFV)

ENV_FRSFB Glycoprotein 42 (gp42)

1 entry

Friend spleen focus-forming virus (strain Lilly-Steeves) (FSFFV)

ENV_FRSFL Glycoprotein 55 (gp55)

1 entry

Harvey murine sarcoma virus

RASH_MSVHA Transforming protein p29 [Cleaved into: Transforming protein p21]

1 entry

Kirsten murine sarcoma virus

RASK_MSVKI GTPase KRas (Ki-Ras) (Transforming protein p21/K-Ras)

1 entry

Mink cell focus-forming murine leukemia virus

ENV_MCFF Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Mink cell focus-forming murine leukemia virus (isolate CI-3)

ENV_MCFF3 Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Moloney murine leukemia virus (strain neuropathogenic variant ts1-92b) (MoMLV)

GGAG_MLVMN Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80) ...

1 entry

Moloney murine sarcoma virus (strain HT-1) (MoMSV)

MOS_MSVMH Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

1 entry

Moloney murine sarcoma virus (strain m1) (MoMSV)

MOS_MSVMM Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

1 entry

Murine leukemia virus (strain DEF27)

GAG_MLVDE Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Murine sarcoma virus 3611

RAF_MSV36 Serine/threonine-protein kinase-transforming protein raf (EC 2.7.11.1)

1 entry

Murine sarcoma virus NS.C58

RASH_MSVNS GTPase HRas (Transforming protein p21/H-Ras)

1 entry

Myeloproliferative sarcoma virus (isolate ts159)

MOS_MSVTS Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

1 entry

Radiation murine leukemia virus (strain Kaplan)

ENV_MLVRK Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 76) ...

1 entry

Rasheed rat sarcoma virus

RASH_RRASV Transforming protein p29 [Cleaved into: Transforming protein p21]

1 entry

Rauscher mink cell focus-inducing virus

ENV_RMCFV Envelope glycoprotein (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 70) ...

1 entry

Rauscher spleen focus-forming virus (RSFFV)

ENV_RSFFV Glycoprotein 55 (gp55)