Inhibition of host IRF9 by virus

IRF9 is a key transcriptional factor involved in the signaling pathway leading to expression of hundreds of interferon stimulated genes (ISGs). Under normal conditions, IRF9 exists in a latent form in the cytoplasm. Viral infection triggers the activation of IRF9 bound to STAT1 and STAT2 forming the ISGF3 complex. ISGF3 complex translocates to the nucleus and binds to specific regulatory DNA sequences called IFN-stimulated response elements (ISREs). ISGF3 binding to ISREs initiates the transcription of many IFN-stimulated genes (ISGs).

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9

Several viruses involved in the evasion of the type I and III interferon pathway by inhibiting the interferon regulatory factor-9 protein. The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-alpha. The reovirus µ2 protein induces unusual nuclear accumulation of IRF9 and represses IFN-stimulated gene (ISG) expression.

Matching UniProtKB/Swiss-Prot entries

3 entries grouped by strain (browse by keywords)

1 entry

Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain

MU2_REOVL Microtubule-associated protein mu-2 (Mu2)

1 entry

Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3) reference strain

MU2_REOVD Microtubule-associated protein mu-2 (Mu2)

1 entry

Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2)

MU2_REOVJ Microtubule-associated protein mu-2 (Mu2)