Inhibition of host IRF3 by virus (kw:KW-1092)
IRF3 is a key transcriptional factor involved in the signaling pathway leading to establishment of antiviral state in infected cells. Under normal conditions, IRF3 exists in a latent form in the cytoplasm. Viral infection triggers the phosphorylation of IRF3 C-terminal region. The activated IRF3 migrates to the nucleus, where it complexes with the transcription coactivator CBP/p300, leading to the transcriptional activation of the IFN-alpha and IFN-beta genes.

Due to its crucial role in innate response, IRF3 is the target of many viral proteins. Some viral proteins interact with IRF3 and prevent its phosphorylation such as SARS coronavirus PLpro protein, while others target IRF3 for proteasome-dependent degradation, like bICP0.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)173 entries grouped by protein
4 entries
Protein MGF 360-14L
1 entry
Protein E3 homolog (Protein E3L homolog)
7 entries
E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ubiquitin transferase ICP0)
1 entry
mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)
1 entry
Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)
3 entries
Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
5 entries
Minor capsid protein M1249L (pM1249L)
1 entry
Protein ML (ML)
1 entry
Nucleoprotein (Nucleocapsid protein) (Protein N)
7 entries
Non-structural protein 1 (Non-structural protein 1C)
6 entries
Non-structural protein 2 (NS2) (Non-structural protein 1B)
41 entries
Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)
1 entry
Non-structural protein NS-S (NSs)
1 entry
Protein ORF3 (pORF3) (Vp13)
5 entries
Structural protein p14.5
5 entries
Protein OPG036 (Protein N2)
4 entries
RNA-binding protein OPG065 (RNA-binding protein E3) (p25)
4 entries
Protein OPG176
8 entries
Genome polyprotein
1 entry
Non-structural polyprotein pORF1
2 entries
65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein UL83)
26 entries
Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
7 entries
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
5 entries
Protein V
16 entries
Protein E6
1 entry
Envelope small membrane protein (E protein) (sM protein)
5 entries
Uncharacterized protein E301R
1 entry
VIRF-1
1 entry
Viral IRF2-like protein (vIRF-2)
2 entries