Inhibition of host IRF3 by virus (kw:KW-1092)
IRF3 is a key transcriptional factor involved in the signaling pathway leading to establishment of antiviral state in infected cells. Under normal conditions, IRF3 exists in a latent form in the cytoplasm. Viral infection triggers the phosphorylation of IRF3 C-terminal region. The activated IRF3 migrates to the nucleus, where it complexes with the transcription coactivator CBP/p300, leading to the transcriptional activation of the IFN-alpha and IFN-beta genes.

Due to its crucial role in innate response, IRF3 is the target of many viral proteins. Some viral proteins interact with IRF3 and prevent its phosphorylation such as SARS coronavirus PLpro protein, while others target IRF3 for proteasome-dependent degradation, like bICP0.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)173 entries grouped by strain
3 entries
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain
3 entries
Monkeypox virus reference strain
3 entries
Vaccinia virus (strain Copenhagen) (VACV) reference strain
3 entries
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
3 entries
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain
2 entries
Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain
2 entries
Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain
2 entries
Human coronavirus 229E (HCoV-229E) reference strain
2 entries
Human coronavirus NL63 (HCoV-NL63) reference strain
2 entries
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
2 entries
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
2 entries
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
2 entries
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
2 entries
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
2 entries
Human respiratory syncytial virus B (strain B1) reference strain
2 entries
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
2 entries
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain
1 entry
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
1 entry
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
1 entry
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
1 entry
Bovine viral diarrhea virus (isolate NADL) (BVDV) (Mucosal disease virus) reference strain
1 entry
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
1 entry
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
1 entry
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain
1 entry
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
1 entry
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1) reference strain
1 entry
Human coronavirus OC43 (HCoV-OC43) reference strain
1 entry
Human papillomavirus 30 reference strain
1 entry
Human papillomavirus 31 reference strain
1 entry
Human papillomavirus 35 reference strain
1 entry
Human papillomavirus 39 reference strain
1 entry
Human papillomavirus type 16 reference strain
1 entry
Human papillomavirus type 18 reference strain
1 entry
Human papillomavirus type 26 reference strain
1 entry
Human papillomavirus type 34 reference strain
1 entry
Human papillomavirus type 70 reference strain
1 entry
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1) reference strain
1 entry
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
1 entry
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
1 entry
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain
1 entry
Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58)) reference strain
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Rotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A) reference strain
1 entry
Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both)) reference strain
1 entry
Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C) reference strain
1 entry
Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain
1 entry
Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain
1 entry
Thogoto virus (isolate SiAr 126) (Tho) reference strain
4 entries
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
4 entries
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
4 entries
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)
4 entries
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)
3 entries
Porcine epidemic diarrhea virus (strain CV777) (PEDV)
2 entries
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005)
2 entries
Human respiratory syncytial virus
2 entries
Human respiratory syncytial virus A (strain A2)
2 entries
Human respiratory syncytial virus B (strain 18537)
2 entries
Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)
1 entry
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
1 entry
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
1 entry
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
1 entry
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
1 entry
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
1 entry
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
1 entry
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
1 entry
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
1 entry
Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)
1 entry
Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)
1 entry
Bovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal disease virus)
1 entry
Bovine viral diarrhea virus (strain SD-1) (BVDV) (Mucosal disease virus)
1 entry
Classical swine fever virus (strain Alfort/Tuebingen) (CSFV) (Hog cholera virus)
1 entry
Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus)
1 entry
Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)
1 entry
Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)
1 entry
Heartland virus (HTRV)
1 entry
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1)
1 entry
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
1 entry
Human papillomavirus 33
1 entry
Human papillomavirus 45
1 entry
Human papillomavirus 51
1 entry
Human papillomavirus 52
1 entry
Human papillomavirus 58
1 entry
Human papillomavirus 68
1 entry
Human papillomavirus 69
1 entry
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)
1 entry
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
1 entry
Rotavirus A (isolate RVA/Cat/Japan/FRV64/1989/G3P5B[3]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Cow/South/Africa/Offal agent/1965/G8P6[1]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Cow/Thailand/A44/1988/G10P8[11]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A) (Rotavirus A (isolate H-2))
1 entry
Rotavirus A (isolate RVA/Equine/United Kingdom/L338/1988/G13P12[18]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus A (isolate B4106))
1 entry
Rotavirus A (isolate RVA/Human/India/116E/1986/G9P8[11]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Human/Japan/IGV-80-3/XXXX/GXP[X]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Monkey/United States/TUCH/2003/G3P[24]) (RV-A)
1 entry
Rotavirus A (isolate RVA/Mouse/Brazil/EHP/1981/G16P[20]) (RV-A)
1 entry
Rotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)
1 entry
Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
1 entry
Rotavirus A (strain RVA/Cow/United States/B641/XXXX/G6P7[5]) (RV-A)
1 entry
Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus (strain Wistar calf 3))
1 entry
Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)
1 entry
Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
1 entry
Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)
1 entry
Rotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)
1 entry
Rotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)
1 entry
Rotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))
1 entry
Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))
1 entry
Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
1 entry
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)
1 entry
Rotavirus A (strain RVA/Human/Venezuela/M37/1982/G1P2A[6]) (RV-A)
1 entry
Rotavirus A (strain RVA/Monkey/United States/RRV/1975/G3P5B[3]) (RV-A)
1 entry
Rotavirus A (strain RVA/Pig/Mexico/YM/1983/G11P9[7]) (RV-A)
1 entry
Rotavirus A (strain RVA/Pig/United States/Gottfried/1983/G4P2B[6]) (RV-A)
1 entry
Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))
1 entry
Rotavirus A (strain RVA/Rabbit/United States/ALA/XXXX/G3P11[14]) (RV-A) (Rotavirus A (strain Alabama))
1 entry
Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
1 entry
Rotavirus A (strain RVA/SA11-FEM/G3P6[1]) (RV-A) (Simian Agent 11 (strain FEM))
1 entry
Rotavirus A (strain RVA/SA11-Patton/G3P[X]) (RV-A) (Simian Agent 11 (strain Patton))
1 entry
Rotavirus C (strain RVC/Pig/United States/Cowden/1980) (RV-C)
1 entry
Sendai virus (strain Fushimi) (SeV)
1 entry
Sendai virus (strain Hamamatsu) (SeV)
1 entry
Sendai virus (strain Harris) (SeV)
1 entry
Sendai virus (strain Ohita) (SeV)
1 entry
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))
1 entry
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))
1 entry
Theiler's murine encephalomyelitis virus (strain BeAn 8386) (TMEV)
1 entry
Theiler's murine encephalomyelitis virus (strain DA) (TMEV)
1 entry
Variola virus
1 entry