Ephemerovirus

VIRION

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Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

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Negative-stranded RNA linear genome, about 14.6-14.8 kb in size. Encodes for 5 to 9 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by strain (browse by keywords)

12 entries

Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

Select_allDeselect_all
VPA1_BEFVB Protein alpha-1
VPB_BEFVB Protein beta
VPA3_BEFVB Protein alpha-3
VGLN_BEFVB Non-structural glycoprotein GNS
MATRX_BEFVB Matrix protein
L_BEFVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_BEFVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
VPP_BEFVB Putative protein P'
GLYCO_BEFVB Glycoprotein
PHOSP_BEFVB Phosphoprotein (Protein P) (Protein M1)
VPA2_BEFVB Protein alpha-2
VPG_BEFVB Protein gamma

6 entries

Adelaide River virus (ARV)

Select_allDeselect_all
VPA2_ARV Protein alpha-2
VPB_ARV Protein beta
VPA1_ARV Protein alpha-1
GLYCO_ARV Glycoprotein
NCAP_ARV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
VGLN_ARV Non-structural glycoprotein