Dinovernavirus (taxid:699180)



Non enveloped, turreted virion with a T=2* icosahedral symmetry, about 49-50 nm in diameter. The capsid is composed of only a single shell of protein.



Segmented linear dsRNA genome. Contains 9 segments encoding for at least 9 proteins.


The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase synthesizes a capped mRNA from each dsRNA segment. This capped mRNA is translocated to the cell cytoplasm where it is translated.




  1. Attachment to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

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9 entries grouped by strain

9 entries

Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

VP6_APRVF Microtubule-associated protein VP6
VP5_APRVF Outer capsid protein VP5 [Includes: mRNA guanylyltransferase (EC; mRNA ...
CAPSD_APRVF Putative major capsid protein VP3
RDRP_APRVF RNA-directed RNA polymerase VP2 (EC
VP9_APRVF Uncharacterized protein VP9
VP8_APRVF Uncharacterized protein VP8
VP7_APRVF Uncharacterized protein VP7
VP4_APRVF Putative non-structural protein 4 (NS4)
VP1_APRVF Putative structural protein VP1