Pneumoviridae (taxid:11244)

VIRION

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Enveloped, spherical. Diameter from about 150nm nm.

GENOME

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Negative-stranded RNA linear genome, about 13-15 kb in size. Encodes for 8 to 11 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The NS2 protein plays a role in inhibition of RIG-I antiviral signaling

The NS1 protein plays a role in inhibition of MAVS antiviral signaling

Activation of host NF-kappa-B

The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

0 entry grouped by strain

These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Canine pneumovirus taxid:1408279

Protein ModelArchive
Matrix protein M2-2 ma-jd-viral-61345
Protein M2-1 ma-jd-viral-32281

Human respiratory syncytial virus taxid:11250

Protein ModelArchive
Fusion glycoprotein F0 ma-jd-viral-42968
Matrix protein (M protein) ma-jd-viral-03354
Non-structural protein 1 (Non-structural protein 1C) ma-jd-viral-40536
Non-structural protein 2 (Non-structural protein 1B) ma-jd-viral-50993
Nucleoprotein ma-jd-viral-52617
Phosphoprotein ma-jd-viral-35127
Protein M2-1 ma-jd-viral-32282
Small hydrophobic protein (Small protein 1A) ma-jd-viral-51897
Transcription-replication factor M2-2 ma-jd-viral-32316

Human respiratory syncytial virus B (strain B1) taxid:79692

Protein ModelArchive
Fusion glycoprotein F0 (Protein F) ma-jd-viral-42968
Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein)... ma-jd-viral-54372
Matrix protein (M protein) ma-jd-viral-03354
Non-structural protein 1 (Non-structural protein 1C) ma-jd-viral-40536
Non-structural protein 2 (NS2) (Non-structural protein 1B) ma-jd-viral-50993
Nucleoprotein (Protein N) (Nucleocapsid protein) ma-jd-viral-52617
Phosphoprotein (Protein P) ma-jd-viral-35127
Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor... ma-jd-viral-32282
Protein M2-2 ma-jd-viral-32316
Small hydrophobic protein (Small protein 1A) ma-jd-viral-51897

Pneumonia virus of mice J3666 taxid:270473

Protein ModelArchive
Attachment protein ma-jd-viral-33782
Fusion glycoprotein F0 ma-jd-viral-42981
M2-2 ma-jd-viral-61346
Matrix protein (M protein) ma-jd-viral-03353
NS1 protein (Non-structural protein 1) ma-jd-viral-58037
NS2 protein (Non-structural protein 2) ma-jd-viral-30918
Nucleoprotein ma-jd-viral-52618
Phosphoprotein ma-jd-viral-35128
Protein M2-1 ma-jd-viral-32283
Small hydrophobic protein ma-jd-viral-52217
p2 ma-jd-viral-39714