Betairidovirinae

VIRION

Polyhedral virions 185 nm in diameter. The capsid displays an icosahedral symmetry T=147, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.

GENOME

Linear, dsDNA genome of 135 to 213 kb. The genome contains terminal and redundant sequences and is circularly permuted. According to a recent estimation, IIV-6 genome might encode about 211 proteins. The genome is not methylated.

GENE EXPRESSION

there are classical or slightly modified canonical promoters and termination signals upstream and downstream of the start and stop codons of most ORFs.

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Attachment of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

Chilo iridescent virus encodes a functional inhibitor of apoptosis (IAP) . The grouper iridovirus (GIV) contains an antiapoptotic B-cell lymphoma (Bcl)-2-like gene that also inhibits host apoptosis.?

Invertebrate iridescent virus 3 encodes a protein homolog to the Chilo iridescent virus functional inhibitor of apoptosis (IAP) . This ORF may therefore play a role in the modulation of host apoptosis.

Matching UniProtKB/Swiss-Prot entries

347 entries grouped by strain (browse by keywords)

215 entries

Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) reference strain

Select_allDeselect_all
VF350_IIV6 Uncharacterized protein 350L
VF329_IIV6 Uncharacterized protein 329R
VF359_IIV6 Uncharacterized protein 359L
VF355_IIV6 Putative CTD phosphatase-like protein 355R (EC 3.1.3.-)
VF439_IIV6 Probable kinase 439L (EC 2.7.-.-)
VF369_IIV6 Probable RAD2-like endonuclease 369L (EC 3.1.-.-)
TYSY_IIV6 Probable thymidylate synthase 225R (EC 2.1.1.45)
VF077_IIV6 Putative zinc finger protein 077L
VF213_IIV6 Transmembrane protein 213R
VF335_IIV6 Uncharacterized protein 335L
VF203_IIV6 Uncharacterized protein 203L
VF337_IIV6 Putative membrane protein 337L
VF357_IIV6 Uncharacterized protein 357R
VF019_IIV6 Uncharacterized protein 019R
VF282_IIV6 Putative transcription factor 282R
VF118_IIV6 Putative myristoylated protein 118L
VF306_IIV6 Putative SWIB domain-containing protein 306R
VF295_IIV6 Uncharacterized protein 295L
VF396_IIV6 Uncharacterized protein 396L
VF453_IIV6 Putative thioredoxin-like protein 453L
VF201_IIV6 Putative Bro-N domain-containing protein 201R
VF075_IIV6 Uncharacterized protein 075L
VF229_IIV6 Uncharacterized protein 229L
VF391_IIV6 Uncharacterized protein 391R
VF244_IIV6 Putative phosphoesterase 244L (EC 3.1.-.-)
VF259_IIV6 Uncharacterized protein 259R
VF307_IIV6 Uncharacterized protein 307L
VF030_IIV6 Uncharacterized protein 030L
VF378_IIV6 Uncharacterized protein 378R
VF415_IIV6 Uncharacterized protein 415R
VF198_IIV6 Uncharacterized protein 198R
082L_IIV6 Uncharacterized protein 082L
104L_IIV6 Uncharacterized protein 104L
140L_IIV6 Uncharacterized protein 140L
250L_IIV6 Uncharacterized protein 250L
227L_IIV6 Uncharacterized protein 227L
240R_IIV6 Uncharacterized protein 240R
308L_IIV6 Uncharacterized protein 308L
312R_IIV6 Uncharacterized protein 312R
373L_IIV6 Uncharacterized protein 373L
006L_IIV6 Putative KilA-N domain-containing protein 006L
149L_IIV6 Uncharacterized protein 149L
284R_IIV6 Uncharacterized protein 284R
273R_IIV6 Uncharacterized protein 273R
313L_IIV6 Putative KilA-N domain-containing protein 313L
317L_IIV6 Uncharacterized protein 317L
374R_IIV6 Uncharacterized protein 374R
375R_IIV6 Uncharacterized protein 375R
411L_IIV6 Uncharacterized protein 411L
139L_IIV6 Uncharacterized protein 139L
285L_IIV6 Uncharacterized protein 285L
293R_IIV6 Uncharacterized protein 293R
206L_IIV6 Uncharacterized protein 206L
120L_IIV6 Uncharacterized protein 120L
388R_IIV6 Putative MSV199 domain-containing protein 388R
141R_IIV6 Uncharacterized protein 141R
192R_IIV6 Uncharacterized protein 192R
160L_IIV6 Uncharacterized protein 160L
249R_IIV6 Uncharacterized protein 249R
211L_IIV6 Putative MSV199 domain-containing protein 211L
241L_IIV6 Cysteine-rich uncharacterized protein 241L
300R_IIV6 Transmembrane protein 300R
343L_IIV6 Probable DNA-directed RNA polymerase subunit 343L (EC 2.7.7.6)
346R_IIV6 Uncharacterized protein 346R
325L_IIV6 Uncharacterized protein 325L
165R_IIV6 Putative metalloproteinase 165R (EC 3.4.24.-)
122R_IIV6 Uncharacterized protein 122R
127L_IIV6 Uncharacterized protein 127L
209R_IIV6 Uncharacterized protein 209R
361L_IIV6 Probable cysteine proteinase 361L (EC 3.4.-.-)
096L_IIV6 Putative FAS1 domain-containing protein 096L
458R_IIV6 Putative myristoylated membrane protein 458R
468L_IIV6 Putative MSV199 domain-containing protein 468L
041L_IIV6 Uncharacterized protein 041L
094L_IIV6 Uncharacterized protein 094L
146R_IIV6 Putative MSV199 domain-containing protein 146R
VF098_IIV6 Uncharacterized protein 098R
VF309_IIV6 Uncharacterized protein 309L
VF268_IIV6 Uncharacterized protein 268L
VF358_IIV6 Uncharacterized protein 358L
VF050_IIV6 Uncharacterized protein 050L
VF143_IIV6 Putative kinase protein 143R (EC 2.7.-.-)
VF224_IIV6 Probable cysteine proteinase 224L (EC 3.4.-.-)
VF179_IIV6 Uncharacterized protein 179R
VF184_IIV6 Putative helicase 184R (EC 3.6.4.-)
RPB1_IIV6 Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC 2.7.7.6)
TOP2_IIV6 DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
RNC_IIV6 Putative ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III)
VF117_IIV6 Uncharacterized protein 117L
RIR2_IIV6 Probable ribonucleoside-diphosphate reductase small subunit 376L (EC 1.17.4.1) (Ribonucleotide ...
110R_IIV6 Uncharacterized protein 110R
113L_IIV6 Uncharacterized protein 113L
106L_IIV6 Uncharacterized protein 106L
107L_IIV6 Uncharacterized protein 107L
MCP_IIV6 Major capsid protein (MCP) (P50)
RPB2_IIV6 Probable DNA-directed RNA polymerase II subunit RPB2 homolog (EC 2.7.7.6)
VF115_IIV6 Uncharacterized protein 115R
VF161_IIV6 Putative helicase 161L (EC 3.6.4.-)
VF232_IIV6 Putative ubiquitin thioesterase 232R (EC 3.4.19.12)
VF157_IIV6 Putative RING finger protein 157L
VF395_IIV6 Uncharacterized protein 395R
VF155_IIV6 Uncharacterized protein 155L
VF342_IIV6 Uncharacterized protein 342R
VF467_IIV6 Uncharacterized protein 467R
VF349_IIV6 Putative transcription elongation factor S-II-like protein 349L
VF380_IIV6 Probable serine/threonine-protein kinase 380R (EC 2.7.11.1)
VF197_IIV6 Putative tyrosine phosphatase 197R (EC 3.1.3.-)
VF193_IIV6 Apoptosis inhibitor 193R
RIR1_IIV6 Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase large ...
VF170_IIV6 Uncharacterized protein 170L
VF466_IIV6 Uncharacterized protein 466R
VF414_IIV6 Putative hydrolase 414L (EC 3.6.1.-)
VF067_IIV6 Uncharacterized protein 067R
VF219_IIV6 Uncharacterized protein 219L
VF347_IIV6 Putative FAD-linked sulfhydryl oxidase 347L (EC 1.8.3.2)
VF145_IIV6 Uncharacterized protein 145L
VF136_IIV6 Uncharacterized protein 136R
VF205_IIV6 Putative DNA ligase 205R (EC 6.5.1.2)
VF010_IIV6 Transmembrane protein 010R
VF196_IIV6 Uncharacterized protein 196R
VF022_IIV6 Putative helicase 022L (EC 3.6.4.-)
VF302_IIV6 Putative zinc finger protein 302L
VF436_IIV6 Uncharacterized protein 436R
KTHY_IIV6 Putative thymidylate kinase 251L (EC 2.7.4.9) (dTMP kinase)
PARP_IIV6 Putative poly [ADP-ribose] polymerase-like 100L (EC 2.4.2.30)
236L_IIV6 Uncharacterized protein 236L
348R_IIV6 Uncharacterized protein 348R
315L_IIV6 Putative KilA-N domain-containing protein 315L
032R_IIV6 Uncharacterized protein 032R
084L_IIV6 Uncharacterized protein 084L
138R_IIV6 Uncharacterized protein 138R
385L_IIV6 Uncharacterized protein 385L
404L_IIV6 Uncharacterized protein 404L
457L_IIV6 Uncharacterized protein 457L
ICP46_IIV6 Immediate-early protein ICP-46 homolog
255L_IIV6 Uncharacterized protein 255L
235L_IIV6 Putative methyltransferase 235L (EC 2.1.1.-)
DPOL_IIV6 DNA polymerase 037L (EC 2.7.7.7)
121R_IIV6 Putative RING finger protein 121R
130R_IIV6 Uncharacterized protein 130R
246L_IIV6 Uncharacterized protein 246L
242L_IIV6 Putative GIY-YIG domain-containing protein 242L
441R_IIV6 Uncharacterized protein 441R
443R_IIV6 Uncharacterized protein 443R
195L_IIV6 Uncharacterized protein 195L
132L_IIV6 Putative zinc finger protein 132L
218R_IIV6 Uncharacterized protein 218R
HMGH_IIV6 High mobility group protein homolog
460R_IIV6 Uncharacterized protein 460R
009R_IIV6 Uncharacterized protein 009R
056R_IIV6 Uncharacterized protein 056R
101L_IIV6 Uncharacterized protein 101L
123R_IIV6 Putative tyrosine phosphatase 123R (EC 3.1.3.-)
126R_IIV6 Uncharacterized protein 126R
332L_IIV6 Uncharacterized RING finger protein 332L
366R_IIV6 Uncharacterized protein 366R
389L_IIV6 Probable serine/threonine-protein kinase 389L (EC 2.7.11.1)
426R_IIV6 Uncharacterized protein 426R
454R_IIV6 Putative DNA-directed RNA polymerase subunit 454R
137R_IIV6 Uncharacterized protein 137R
422L_IIV6 Uncharacterized protein 422L
423L_IIV6 Uncharacterized protein 423L
169L_IIV6 Uncharacterized protein 169L
148R_IIV6 Putative MSV199 domain-containing protein 148R
159L_IIV6 Uncharacterized protein 159L
247L_IIV6 Uncharacterized protein 247L
272L_IIV6 Uncharacterized protein 272L
216R_IIV6 Uncharacterized protein 216R
368R_IIV6 Uncharacterized protein 368R
451L_IIV6 Uncharacterized protein 451L
034R_IIV6 Uncharacterized protein 034R
043L_IIV6 Uncharacterized protein 043L
234R_IIV6 Uncharacterized protein 234R
384L_IIV6 Uncharacterized protein 384L
301L_IIV6 Uncharacterized protein 301L
322R_IIV6 Uncharacterized protein 322R
420R_IIV6 Putative MSV199 domain-containing protein 420R
172L_IIV6 Putative helicase 172L (EC 3.6.4.-)
095L_IIV6 Putative RING finger protein 095L
083L_IIV6 Uncharacterized protein 083L
254L_IIV6 Uncharacterized protein 254L
437L_IIV6 Uncharacterized protein 437L
400R_IIV6 Uncharacterized protein 400R
463L_IIV6 Probable lipid hydrolase 463L (EC 3.1.1.-)
049L_IIV6 Transmembrane protein 049L
060L_IIV6 Uncharacterized protein 060L
061R_IIV6 Uncharacterized protein 061R
065R_IIV6 Uncharacterized protein 065R
116L_IIV6 Uncharacterized protein 116L
226R_IIV6 Uncharacterized protein 226R
238R_IIV6 Putative MSV199 domain-containing protein 238R
413R_IIV6 Putative RING finger protein 413R
438L_IIV6 Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP ...
044R_IIV6 Uncharacterized protein 044R
042R_IIV6 Uncharacterized protein 042R
071L_IIV6 Uncharacterized protein 071L
287R_IIV6 Uncharacterized protein 287R
026R_IIV6 Uncharacterized protein 026R
069L_IIV6 Putative Bro-N domain-containing protein 069L
062L_IIV6 Uncharacterized protein 062L
135R_IIV6 Uncharacterized protein 135R
156R_IIV6 Uncharacterized protein 156R
253L_IIV6 Uncharacterized protein 253L
228L_IIV6 Uncharacterized protein 228L
200R_IIV6 Putative MSV199 domain-containing protein 200R
212L_IIV6 Putative MSV199 domain-containing protein 212L
340R_IIV6 DRBM domain-containing protein 340R
289L_IIV6 Putative Bro-N domain-containing protein 289L
261R_IIV6 Uncharacterized protein 261R
EXON_IIV6 Putative exonuclease 012L (EC 3.1.11.-)
029R_IIV6 Uncharacterized protein 029R
111R_IIV6 Uncharacterized protein 111R
175R_IIV6 Putative RING finger protein 175R
162R_IIV6 Uncharacterized protein 162R
221L_IIV6 Uncharacterized protein 221L

126 entries

Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) reference strain

Select_allDeselect_all
VF184_IIV3 Putative helicase 121R (EC 3.6.4.-)
VF391_IIV3 Uncharacterized protein 058R
VF342_IIV3 Uncharacterized protein 115R
VF203_IIV3 Uncharacterized protein 085L
VF287_IIV3 Uncharacterized protein 056L
VF439_IIV3 Probable kinase 098L (EC 2.7.-.-)
VF357_IIV3 Transmembrane protein 066L
VF436_IIV3 Uncharacterized protein 060L
VF224_IIV3 Probable cysteine proteinase 024R (EC 3.4.-.-)
VF115_IIV3 Uncharacterized protein 031R
VF358_IIV3 Uncharacterized protein 083L
VF467_IIV3 Uncharacterized protein 061R
VF415_IIV3 Uncharacterized protein 018L
VF170_IIV3 Uncharacterized protein 97L
VF136_IIV3 Uncharacterized protein 042R
VF369_IIV3 Probable RAD2-like endonuclease 076L (EC 3.1.-.-)
VF380_IIV3 Probable serine/threonine-protein kinase 010L (EC 2.7.11.1)
VF401_IIV3 High mobility group protein homolog 068R
VF309_IIV3 Uncharacterized protein 063R
VF205_IIV3 Putative DNA ligase 052L (EC 6.5.1.2)
VF201_IIV3 Putative Bro-N domain-containing protein 019R
VF359_IIV3 Uncharacterized protein 105R
VF302_IIV3 Putative zinc finger protein 012R
VF395_IIV3 Uncharacterized protein 001R
VF030_IIV3 Uncharacterized protein 106R
VF229_IIV3 Uncharacterized protein 229L
VF282_IIV3 Putative transcription factor 079L
VF050_IIV3 Uncharacterized protein 094L
VF350_IIV3 Uncharacterized protein 026R
VF098_IIV3 Uncharacterized protein 038R
VF219_IIV3 Uncharacterized protein 036R
VF307_IIV3 Uncharacterized protein 033L
VF347_IIV3 Putative FAD-linked sulfhydryl oxidase 096R (EC 1.8.3.2)
VF155_IIV3 Uncharacterized protein 113L
VF193_IIV3 Putative apoptosis inhibitor 021L
VF268_IIV3 Uncharacterized protein 074L
VF213_IIV3 Uncharacterized protein 051L
008L_IIV3 Uncharacterized protein 008L
037L_IIV3 Uncharacterized protein 037L
080R_IIV3 Putative hydrolase 080R (EC 3.6.1.-)
081L_IIV3 Putative FAS1 domain-containing protein 081L
054L_IIV3 Uncharacterized protein 054L
102R_IIV3 Uncharacterized protein 102R
114L_IIV3 Uncharacterized protein 114L
022L_IIV3 Transmembrane protein 022L
064L_IIV3 Uncharacterized protein 064L
075R_IIV3 Uncharacterized protein 075R
118R_IIV3 Uncharacterized protein 118R
119R_IIV3 Uncharacterized protein 119R
028R_IIV3 Uncharacterized protein 028R
030L_IIV3 uncharacterized protein 030L
062L_IIV3 Uncharacterized protein 062L
073R_IIV3 Uncharacterized protein 073R
103L_IIV3 Uncharacterized protein 103L
124R_IIV3 Uncharacterized protein 124R
025R_IIV3 Uncharacterized protein 025R
057L_IIV3 Uncharacterized protein 057L
045R_IIV3 Uncharacterized protein 045R
005L_IIV3 Uncharacterized protein 005L
125R_IIV3 Uncharacterized protein 125R
VF259_IIV3 Uncharacterized protein 071L
RPB1_IIV3 Probable DNA-directed RNA polymerase II subunit RPB1 homolog (EC 2.7.7.6)
TOP2_IIV3 DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
VF355_IIV3 Putative CTD phosphatase-like protein 355R (EC 3.1.3.-)
VF143_IIV3 Putative kinase protein 029R (EC 2.7.-.-)
VF117_IIV3 Uncharacterized protein 107R
RIR2_IIV3 Probable ribonucleoside-diphosphate reductase small subunit 048L (EC 1.17.4.1) (Ribonucleotide ...
RPB2_IIV3 Probable DNA-directed RNA polymerase II subunit RPB2 homolog (EC 2.7.7.6)
RNC_IIV3 Putative ribonuclease 3 (EC 3.1.26.3)
RIR1_IIV3 Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase large ...
011L_IIV3 Uncharacterized protein 011L
040R_IIV3 Uncharacterized protein 040R
072L_IIV3 Uncharacterized protein 072L
108L_IIV3 Uncharacterized protein 108L
122R_IIV3 Uncharacterized protein 122R
VF295_IIV3 Uncharacterized protein 016R
VF396_IIV3 Uncharacterized protein 091L
VF067_IIV3 Uncharacterized protein 004R
VF244_IIV3 Putative phosphoesterase 078R (EC 3.1.-.-)
VF196_IIV3 Uncharacterized protein 020R
VF198_IIV3 Uncharacterized protein 069L
VF075_IIV3 Uncharacterized protein 088R
VF378_IIV3 Uncharacterized protein 100L
VF329_IIV3 Uncharacterized protein 099R
VF015_IIV3 Uncharacterized protein 015R
VF179_IIV3 Uncharacterized protein 035R
VF306_IIV3 Putative SWIB domain-containing protein 070L
VF157_IIV3 Putative RING finger protein 027R
VF145_IIV3 Uncharacterized protein 050L
VF118_IIV3 Putative myristoylated protein 006R
VF010_IIV3 Uncharacterized protein 043R
VF337_IIV3 Putative membrane protein 047R
VF197_IIV3 Putative tyrosine phosphatase 067L (EC 3.1.3.-)
VF022_IIV3 Putative helicase 087L (EC 3.6.4.-)
VF335_IIV3 Uncharacterized protein 017R
VF349_IIV3 Putative transcription elongation factor S-II-like protein 055R
VF453_IIV3 Putative thioredoxin-like protein 041R
VF161_IIV3 Putative helicase 109L (EC 3.6.4.-)
VF232_IIV3 Putative ubiquitin thioesterase 232R (EC 3.4.19.12)
VF077_IIV3 Putative zinc finger protein 034R
VF414_IIV3 Putative hydrolase 111R (EC 3.6.1.-)
VF466_IIV3 Uncharacterized protein 112R
VF019_IIV3 Putative MSV199 domain-containing protein 093L
032R_IIV3 Uncharacterized protein 032R
110R_IIV3 Uncharacterized protein 110R
MCP_IIV3 Major capsid protein (MCP)
ICP46_IIV3 Immediate-early protein ICP-46 homolog
EX0N_IIV3 Putative exonuclease 059L (EC 3.1.11.-)
DPOL_IIV3 DNA polymerase 120R (EC 2.7.7.7)
126R_IIV3 Uncharacterized protein 126R
013L_IIV3 Uncharacterized protein IIV3-013L
082L_IIV3 Uncharacterized protein 082L
053L_IIV3 Uncharacterized protein 053L
089L_IIV3 Uncharacterized protein 089L
002R_IIV3 Uncharacterized protein 002R
003L_IIV3 Uncharacterized protein 003L
077R_IIV3 Uncharacterized protein 077R
116R_IIV3 Uncharacterized protein 116R
044L_IIV3 Putative serine/threonine-protein kinase 040L (EC 2.7.11.-)
049R_IIV3 Uncharacterized protein 049R
095L_IIV3 Probable matrix metalloproteinase 095L (EC 3.4.24.-)
123L_IIV3 Uncharacterized protein 123L
007R_IIV3 Uncharacterized protein 007R
023R_IIV3 Uncharacterized protein 023R
092R_IIV3 Uncharacterized protein 092R
117L_IIV3 Uncharacterized protein 117L

2 entries

Simulium iridescent virus (IIV-22) (Insect iridescent virus type 22)

Select_allDeselect_all
VF015_IRV22 Uncharacterized 15.9 kDa protein in MSP 5'region
MCP_IRV22 Major capsid protein (MCP) (P50)

2 entries

Tipula iridescent virus (TIV) (Insect iridescent virus type 1)

Select_allDeselect_all
VL96_IRV1 Putative ubiquitin thioesterase L96 (EC 3.4.19.12)
MCP_IRV1 Major capsid protein (MCP) (P50)

1 entry

Costelytra zealandica iridescent virus (CzIV) (Insect iridescent virus type 16)

MCP_IRV16 Major capsid protein (MCP) (P50)

1 entry

Wiseana iridescent virus (WIV) (Insect iridescent virus type 9)

MCP_IRV9 Major capsid protein (MCP) (P50)