Thogotovirus (taxid:35323)

Thogotovirus is a genus of ssRNA- viruses in the Orthomyxoviridae family that infect mammals and are transmitted by Ticks (arbovirus). In humans, these viruses can cause fevers and encephalitis.



Enveloped, spherical. The virions are 80-120 nm in diameter



segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 6 to 7 segments coding for 7 to 9 proteins. Segments size range from 0.9 to 2.3 kb. Genome total size is about 10 Kb


Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. Segment 6 mRNA can be alternatively spliced, giving rise to mRNA coding for M1 proteins.




  1. Virus attaches to sialic acid receptor though GP protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Matching UniProtKB/Swiss-Prot entries

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11 entries grouped by strain

7 entries

Thogoto virus (isolate SiAr 126) (Tho) reference strain

RDRP_THOGV RNA-directed RNA polymerase catalytic subunit (EC (RNA-directed RNA polymerase subunit P2)
PA_THOGV Polymerase acidic protein (PA) (RNA-directed RNA polymerase subunit P3)
ENV_THOGV Envelope glycoprotein (Surface glycoprotein 75)
NCAP_THOGV Nucleoprotein (Nucleocapsid protein) (Protein N)
M1_THOGV Matrix protein (M1)
ML_THOGV Protein ML (ML)
PB2_THOGV Polymerase basic protein 2 (PB2) (RNA-directed RNA polymerase subunit P3)

4 entries

Dhori virus (strain Indian/1313/61) (Dho)

NCAP_DHVI1 Nucleoprotein (Nucleocapsid protein) (Protein N)
RDRP_DHVI1 RNA-directed RNA polymerase catalytic subunit (EC (RNA-directed RNA polymerase subunit P2)
ENV_DHVI1 Envelope glycoprotein
M1_DHVI1 Matrix protein 1 (M1)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Thogoto virus (isolate SiAr 126) taxid:126796

Protein ModelArchive
Nucleoprotein (Nucleocapsid protein) (Protein N) ma-jd-viral-32091

Thogotovirus thogotoense taxid:11569

Protein ModelArchive
Nucleoprotein ma-jd-viral-32091