Modulation of host PP1 activity by virus

Protein phosphatase-1 PP1 is a member of the Serine/Threonine phosphatases. The enzyme regulates many important physiological processes, including gene transcription, translation, metabolism, cell growth and division. Different viruses modulate PP1 phosphatase activity in order to remove phospate from specific cellular substrates. Among them, eIF2alpha phosphorylation seems to be a common target for viral proteins. Indeed, papillomavirus E6, Asfivirus DP71L, herpes virus ICP34.5, EBV EBNA2 are able to dephosphorylate eIF2alpha via interaction with PP1. This mechanism is very important for viruses, since upon infection the host PKR usually trigger the phosphorylation of eIF-2alpha leading to complete shuttoff of translation in the infected cell. By dephosphroylating eIF-2alpha through PP1, viruses manage to circumvent this antiviral response and prevent translational shutoff.

Matching UniProtKB/Swiss-Prot entries

56 entries grouped by protein (browse by keywords)

5 entries

Protein DP71L (MyD116 homolog)

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DP71L_ASFB7
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain
DP71L_ASFWA
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV) reference strain
DP71L_ASFK5
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
DP71L_ASFM2
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
DP71L_ASFP4
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)

3 entries

Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)

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EBNA2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

5 entries

Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

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ICP34_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP34_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP34_HHV1D
Human herpesvirus 1 (strain CVG-2) (HHV-1) (Human herpes simplex virus 1)
ICP34_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
ICP34_HHV1N
Human herpesvirus 1 (strain MGH-10) (HHV-1) (Human herpes simplex virus 1)

43 entries

Protein Tat (Transactivating regulatory protein)

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TAT_HV190
Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain
TAT_HV192
Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1) reference strain
TAT_HV193
Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1) reference strain
TAT_HV1A2
Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) reference strain
TAT_HV1AN
Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain
TAT_HV1B1
Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain
TAT_HV1B9
Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1) reference strain
TAT_HV1BR
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain
TAT_HV1EL
Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain
TAT_HV1ET
Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain
TAT_HV1H2
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain
TAT_HV1MA
Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain
TAT_HV1MV
Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1) reference strain
TAT_HV1RH
Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1) reference strain
TAT_HV1Y2
Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1) reference strain
TAT_HV1YB
Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1) reference strain
TAT_HV1YF
Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain
TAT_SIVCZ
Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
TAT_SIVEK
Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
TAT_SIVMB
Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
TAT_HV112
Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)
TAT_HV196
Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)
TAT_HV197
Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)
TAT_HV19N
Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
TAT_HV1C4
Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)
TAT_HV1H3
Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)
TAT_HV1JR
Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)
TAT_HV1M2
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)
TAT_HV1MN
Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1)
TAT_HV1MP
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)
TAT_HV1ND
Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)
TAT_HV1OY
Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)
TAT_HV1S1
Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)
TAT_HV1S2
Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)
TAT_HV1S3
Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)
TAT_HV1S9
Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)
TAT_HV1SC
Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)
TAT_HV1SE
Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)
TAT_HV1U4
Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1)
TAT_HV1V9
Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)
TAT_HV1VI
Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1)
TAT_HV1Z2
Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)
TAT_HV1Z6
Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)