Modulation of host PP1 activity by virus (kw:KW-1126)

Protein phosphatase-1 PP1 is a member of the Serine/Threonine phosphatases. The enzyme regulates many important physiological processes, including gene transcription, translation, metabolism, cell growth and division. Different viruses modulate PP1 phosphatase activity in order to remove phospate from specific cellular substrates. Among them, eIF2alpha phosphorylation seems to be a common target for viral proteins. Indeed, papillomavirus E6, Asfivirus DP71L, herpes virus ICP34.5, EBV EBNA2 are able to dephosphorylate eIF2alpha via interaction with PP1. This mechanism is very important for viruses, since upon infection the host PKR usually trigger the phosphorylation of eIF-2alpha leading to complete shuttoff of translation in the infected cell. By dephosphroylating eIF-2alpha through PP1, viruses manage to circumvent this antiviral response and prevent translational shutoff.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Host PKR modulation PKR inhibition
PP1 modulation
Links Uniprot Keyword: KW-1126
GO ontology:
Virus -African swine fever virus
(Asfarviridae ,Asfivirus)
-Herpes simplex 1 virus
(Herpesviridae ,Simplexvirus)
-Human papillomavirus 18
(Papillomaviridae ,alphapapillomavirus)
-Epstein-Barr virus
(Herpesviridae ,Lymphocryptovirus)
-HIV
(Retroviridae ,Lentivirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

56 entries grouped by strain

1 entry

African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain

DP71L_ASFB7 Protein DP71L (MyD116 homolog)

1 entry

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

EBNA2_EBVA8 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

EBNA2_EBVB9 Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)

pdb 2MKR; 2N2J; 5HDA

1 entry

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

ICP34_HHV11 Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

ICP34_HHV2H Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

TAT_HV1MA Protein Tat (Transactivating regulatory protein)

pdb 1K5K

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1) reference strain

TAT_HV1U4 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) reference strain

TAT_HV1A2 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain

TAT_HV1BR Protein Tat (Transactivating regulatory protein)

pdb 1JFW; 1JM4

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

TAT_HV1H2 Protein Tat (Transactivating regulatory protein)

pdb 3MI9; 3MIA; 4OR5; 5V61; 6CYT; 6MCE; 6MCF

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1) reference strain

TAT_HV1JR Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain

TAT_HV1MN Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1) reference strain

TAT_HV192 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain

TAT_HV1ET Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain

TAT_HV1EL Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain

TAT_HV190 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain

TAT_HV1YF Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain

TAT_HV1AN Protein Tat (Transactivating regulatory protein)

1 entry

Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

TAT_SIVCZ Protein Tat (Transactivating regulatory protein)

1 entry

Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

TAT_SIVEK Protein Tat (Transactivating regulatory protein)

1 entry

Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

TAT_SIVMB Protein Tat (Transactivating regulatory protein)

1 entry

African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)

DP71L_ASFK5 Protein DP71L (MyD116 homolog)

1 entry

African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)

DP71L_ASFM2 Protein DP71L (MyD116 homolog)

1 entry

African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)

DP71L_ASFP4 Protein DP71L (MyD116 homolog)

1 entry

African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)

DP71L_ASFWA Protein DP71L (MyD116 homolog)

1 entry

Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)

EBNA2_EBVG Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)

1 entry

Human herpesvirus 1 (strain CVG-2) (HHV-1) (Human herpes simplex virus 1)

ICP34_HHV1D Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

1 entry

Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

ICP34_HHV1F Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

1 entry

Human herpesvirus 1 (strain MGH-10) (HHV-1) (Human herpes simplex virus 1)

ICP34_HHV1N Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)

TAT_HV1B1 Protein Tat (Transactivating regulatory protein)

pdb 5L1Z

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)

TAT_HV1C4 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

TAT_HV1H3 Protein Tat (Transactivating regulatory protein)

pdb 4OGR

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)

TAT_HV1OY Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)

TAT_HV112 Protein Tat (Transactivating regulatory protein)

pdb 5SVZ

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)

TAT_HV1RH Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)

TAT_HV1SC Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)

TAT_HV1S1 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)

TAT_HV1S3 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)

TAT_HV1Y2 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)

TAT_HV1B9 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)

TAT_HV1ND Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)

TAT_HV1Z2 Protein Tat (Transactivating regulatory protein)

pdb 1TAC; 1TBC; 1TIV; 2BGN; 2BGR; 8CCW; 8CCZ

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)

TAT_HV1Z6 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)

TAT_HV193 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1)

TAT_HV1VI Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)

TAT_HV1MP Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)

TAT_HV1M2 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)

TAT_HV19N Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)

TAT_HV1SE Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)

TAT_HV1V9 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)

TAT_HV1S9 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)

TAT_HV1S2 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)

TAT_HV196 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)

TAT_HV197 Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)

TAT_HV1YB Protein Tat (Transactivating regulatory protein)

1 entry

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)

TAT_HV1MV Protein Tat (Transactivating regulatory protein)