Protein phosphatase-1 PP1(X70848:9606) is a member of the Serine/Threonine phosphatases. The enzyme regulates many important physiological processes, including gene transcription, translation, metabolism, cell growth and division. Different viruses modulate PP1(X70848:9606) phosphatase activity in order to remove phospate from specific cellular substrates. Among them, eIF2alpha phosphorylation seems to be a common target for viral proteins. Indeed, papillomavirus E6, Asfivirus DP71L(Q65212), herpes virus ICP34.5(P36313), EBV EBNA2(P12978) are able to dephosphorylate eIF2alpha via interaction with PP1(X70848:9606). This mechanism is very important for viruses, since upon infection the host PKR usually trigger the phosphorylation of eIF-2alpha(J02645:9606) leading to complete shuttoff of translation in the infected cell. By dephosphroylating eIF-2alpha(J02645:9606) through PP1(X70848:9606), viruses manage to circumvent this antiviral response and prevent translational shutoff.