Evasion of host immunity by viral interleukin-like protein

Interleukins are secreted regulatory proteins that are members of the family of cytokines (immune system molecules) that regulates immune cell activity. Interleukins are produced by immune system cells such as lymphocytes, macrophages and monocytes, and modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.

Several viruses encode interleukin-like protein that play a role in immune evasion. They have also been shown to activate cellular signaling cascades that enhance virus replication. EBV, HCMV, EHV and orf virus encode for a homolog of interleukin-10 that is able to downregulate Th1 response. HHV-8 protein K2 shares strong homology with IL6 and was thus also named vIL6. Unlike the human IL6, vIL6 does not require the alpha-subunit receptor IL-R6 for signal transduction. Therefore, vIL6 is able to induce antiapoptotic signaling in cells that do not express IL-6R.

Matching UniProtKB/Swiss-Prot entries

11 entries grouped by strain (browse by keywords)

1 entry

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

IL10H_EBVA8 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

IL10H_EBVB9 Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)

1 entry

Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

IL10H_EHV2 Viral interleukin-10 homolog (vIL-10)

1 entry

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain

IL8H_GAHVM Viral interleukin-8 homolog (vIL8)

1 entry

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain

P12I_HTL1C Accessory protein p12I

1 entry

Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) reference strain

P12I_HTL1A Accessory protein p12I

1 entry

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

IL10H_HCMVA Viral interleukin-10 homolog (cmvIL-10) (vIL-10)

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

IL10H_HCMVM Viral interleukin-10 homolog (cmvIL-10) (vIL-10)

1 entry

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

VIL6_HHV8P Viral interleukin-6 homolog (vIL-6)

1 entry

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

IL10H_EBVG Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)

1 entry

Equine herpesvirus 2 (strain T400/3) (EHV-2)

IL10H_EHV2T Viral interleukin-10 homolog (vIL-10)