Inhibition of host TAP by virus (kw:KW-1107)

Transporter associated with antigen (TAP) composed of two subunits TAP1 and TAP2, is required for the translocation of peptides into the ER, where they are loaded onto MHC class I. Both subunits consist of an amino-terminal transmembrane domain and a carboxy-terminal nucleotide cytoplasmic domain.

ICP47 BLN2fa US6

The loading of peptide on MHC by TAP is targeted by several viruses including herpesvirus. ICP47 from HHV-1 binds to the peptide binding site of TAP, with 10-1000 fold higher affinity than most peptides, thereby blocking the first step of the translocation pathway. HCMV US6 instead interacts with human TAP from the RE luminal side and inhibits ATP binding and peptide stimulated ATP hydrolysis. The UL49.5 proteins have different strategies to inhibit TAP. Bovine herpesvirus UL49.5 targets TAP for proteasomal degradation while equine herpesvirus blocks the binding of ATP to TAP. Finally, BNLF2a protein from Epstein-Barr virus prevents the binding of peptides and ATP to TAP.

Matching UniProtKB/Swiss-Prot entries

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11 entries grouped by protein

3 entries

Protein BNLF2a

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

5 entries

ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12)

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
Cercopithecine herpesvirus 16 (CeHV-16) (Herpesvirus papio 2)
Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus)
Herpes simplex virus type 2 (strain SA8) (Simian agent 8)

3 entries

Unique short US6 glycoprotein

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Unique short US6 glycoprotein (Protein HXLF6) (gpUS6)

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Unique short US6 glycoprotein (HXLF6) (gpUS6)